SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CLA_A_CLMA221_0 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	2dkp	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5 (Homo sapiens)	5 / 10	PHE A 87 ALA A 89 LEU A 67 TYR A 52 ILE A 65	None	1.30A	1claA-2dkpA: undetectable	1claA-2dkpA: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_D_KLND1498_1 (CYTOCHROME P450 3A4)	2dkp	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5 (Homo sapiens)	5 / 11	LEU A 50 ILE A 72 ALA A 89 THR A 96 ARG A 83	None	1.29A	2v0mD-2dkpA: undetectable	2v0mD-2dkpA: 12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FPD_A_PZAA1385_0 (HEAT SHOCK-RELATED 70KDA PROTEIN 2)	2dkp	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5 (Homo sapiens)	4 / 7	VAL A 21 GLY A 25 VAL A 44 ARG A 15	None	0.89A	5fpdA-2dkpA: undetectable	5fpdA-2dkpA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FPD_B_PZAB1385_0 (HEAT SHOCK-RELATED 70KDA PROTEIN 2)	2dkp	PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5 (Homo sapiens)	4 / 7	VAL A 21 GLY A 25 VAL A 44 ARG A 15	None	0.91A	5fpdB-2dkpA: undetectable	5fpdB-2dkpA: 17.31

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CLA_A_CLMA221_0","TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE","2dkp","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5","Homo sapiens",5,"PHE A  87;ALA A  89;LEU A  67;TYR A  52;ILE A  65","None","1.30A","1claA-2dkpA:undetectable","1claA-2dkpA:20.97"],["2V0M_D_KLND1498_1","CYTOCHROME P450 3A4","2dkp","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5","Homo sapiens",5,"LEU A  50;ILE A  72;ALA A  89;THR A  96;ARG A  83","None","1.29A","2v0mD-2dkpA:undetectable","2v0mD-2dkpA:12.71"],["5FPD_A_PZAA1385_0","HEAT SHOCK-RELATED 70KDA PROTEIN 2","2dkp","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5","Homo sapiens",4,"VAL A  21;GLY A  25;VAL A  44;ARG A  15","None","0.89A","5fpdA-2dkpA:undetectable","5fpdA-2dkpA:17.31"],["5FPD_B_PZAB1385_0","HEAT SHOCK-RELATED 70KDA PROTEIN 2","2dkp","PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5","Homo sapiens",4,"VAL A  21;GLY A  25;VAL A  44;ARG A  15","None","0.91A","5fpdB-2dkpA:undetectable","5fpdB-2dkpA:17.31"]]