SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2dla 397AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  70
ASN A  89
MET A   4
SER A   9
PHE A   8
 None
 1.43A 1xotB-2dlaA:
undetectable		 1xotB-2dlaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2dla 397AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A  62
LEU A  63
PHE A  66
 None
 0.55A 4pthA-2dlaA:
undetectable		 4pthA-2dlaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2dla 397AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASN A  89
LEU A  69
PHE A  66
LEU A  63
LEU A  15
 None
 0.94A 4rtbA-2dlaA:
undetectable		 4rtbA-2dlaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2dla 397AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A 111
LEU A 152
ILE A 157
ARG A 161
LEU A 169
 None
 1.25A 5nn8A-2dlaA:
undetectable		 5nn8A-2dlaA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2dla 397AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A 169
ASN A 180
LEU A  90
 None
 0.68A 6exiA-2dlaA:
undetectable		 6exiA-2dlaA:
20.37