SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 6 SER X 126
GLY X 124
LEU X  76
GLU X 178
 None
None
YMP  X 601 (-4.8A)
None
 0.91A 1fduD-2dlcX:
undetectable		 1fduD-2dlcX:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 HIS X  53
GLY X 189
ASP X 191
GLN X 192
VAL X 219
 YMP  X 601 (-4.3A)
YMP  X 601 (-2.8A)
YMP  X 601 (-3.2A)
YMP  X 601 (-3.4A)
YMP  X 601 (-3.8A)
 0.85A 1ffyA-2dlcX:
7.5		 1ffyA-2dlcX:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 11 GLY X  45
HIS X  53
GLY X 189
ASP X 191
GLN X 192
 YMP  X 601 (-3.5A)
YMP  X 601 (-4.3A)
YMP  X 601 (-2.8A)
YMP  X 601 (-3.2A)
YMP  X 601 (-3.4A)
 0.70A 1jzsA-2dlcX:
undetectable		 1jzsA-2dlcX:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 11 HIS X  53
GLY X  55
GLY X 189
ASP X 191
VAL X 219
 YMP  X 601 (-4.3A)
YMP  X 601 (-3.5A)
YMP  X 601 (-2.8A)
YMP  X 601 (-3.2A)
YMP  X 601 (-3.8A)
 0.66A 1pg2A-2dlcX:
10.0		 1pg2A-2dlcX:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 HIS X  53
GLY X 189
ASP X 191
GLN X 192
VAL X 219
 YMP  X 601 (-4.3A)
YMP  X 601 (-2.8A)
YMP  X 601 (-3.2A)
YMP  X 601 (-3.4A)
YMP  X 601 (-3.8A)
 0.85A 1qu2A-2dlcX:
7.5		 1qu2A-2dlcX:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 5 ILE X  29
PHE X  66
VAL X 219
PHE X 196
 None
None
YMP  X 601 (-3.8A)
None
 1.22A 2ygnA-2dlcX:
undetectable		 2ygnA-2dlcX:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 LEU X 198
ALA X 175
GLU X 178
LEU X 206
LEU X 203
 None
 1.21A 3erdA-2dlcX:
undetectable		 3erdA-2dlcX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 8 LEU X  76
GLN X 174
TYR X  43
TYR X 170
 YMP  X 601 (-4.8A)
YMP  X 601 (-3.2A)
YMP  X 601 (-4.7A)
YMP  X 601 (-4.6A)
 1.29A 3po7A-2dlcX:
undetectable		 3po7A-2dlcX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 11 LEU X  63
LEU X  76
GLN X 174
TYR X  43
TYR X 170
 None
YMP  X 601 (-4.8A)
YMP  X 601 (-3.2A)
YMP  X 601 (-4.7A)
YMP  X 601 (-4.6A)
 1.43A 4a7aA-2dlcX:
undetectable		 4a7aA-2dlcX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 6 THR X  49
TYR X 101
HIS X  53
TYR X  56
 MG  X 801 (-3.9A)
MG  X 801 (-4.9A)
YMP  X 601 (-4.3A)
YMP  X 601 ( 4.5A)
 1.24A 4df2A-2dlcX:
2.0		 4df2A-2dlcX:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 LYS X  68
LEU X  15
ALA X  64
THR X  61
 None
 1.10A 4iklA-2dlcX:
undetectable
4iklB-2dlcX:
undetectable		 4iklA-2dlcX:
14.96
4iklB-2dlcX:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 8 LEU X 266
VAL X 269
ALA X 311
LEU X 317
 None
 0.85A 4qrcA-2dlcX:
undetectable		 4qrcA-2dlcX:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 11 LEU X 198
ALA X 175
GLU X 178
LEU X 206
LEU X 203
 None
 1.25A 4zn7B-2dlcX:
undetectable		 4zn7B-2dlcX:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 8 PRO X 275
LEU X 109
ILE X 108
LEU X  15
 None
 0.97A 5ieoA-2dlcX:
undetectable		 5ieoA-2dlcX:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 6 LYS X  68
LEU X  15
ALA X  64
THR X  61
 None
 1.23A 5l4iB-2dlcX:
undetectable		 5l4iB-2dlcX:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 8 GLY X 153
GLN X 128
TYR X 133
ASP X 191
 None
None
None
YMP  X 601 (-3.2A)
 1.01A 5vlmB-2dlcX:
undetectable		 5vlmB-2dlcX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		4 / 7 GLY X 153
GLN X 128
TYR X 133
ASP X 191
 None
None
None
YMP  X 601 (-3.2A)
 1.00A 5vlmE-2dlcX:
undetectable		 5vlmE-2dlcX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 ASP X 191
LEU X 203
ALA X 152
LEU X 172
GLN X 128
 YMP  X 601 (-3.2A)
None
None
None
None
 1.08A 6ew0B-2dlcX:
undetectable		 6ew0B-2dlcX:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 ASP X 191
LEU X 203
ALA X 152
LEU X 172
GLN X 128
 YMP  X 601 (-3.2A)
None
None
None
None
 1.08A 6ew0D-2dlcX:
undetectable		 6ew0D-2dlcX:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 ASP X 191
LEU X 203
ALA X 152
LEU X 172
GLN X 128
 YMP  X 601 (-3.2A)
None
None
None
None
 1.09A 6ew0H-2dlcX:
undetectable		 6ew0H-2dlcX:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Saccharomyces
cerevisiae) 		5 / 12 ASP X 191
LEU X 203
ALA X 152
LEU X 172
GLN X 128
 YMP  X 601 (-3.2A)
None
None
None
None
 1.08A 6ew0I-2dlcX:
undetectable		 6ew0I-2dlcX:
14.38