SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 4 VAL A 149
PHE A 161
SER A 204
VAL A 202
 None
 1.33A 1e7cA-2dldA:
undetectable		 1e7cA-2dldA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		5 / 10 LEU A  43
GLY A  46
ALA A  47
ASP A  48
THR A  32
 None
 0.95A 1t7iA-2dldA:
undetectable		 1t7iA-2dldA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		3 / 3 VAL A 229
VAL A 232
ASP A 243
 None
 0.70A 2fumD-2dldA:
undetectable		 2fumD-2dldA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 7 TYR A  53
TYR A 102
ARG A  10
ARG A  77
 None
 1.45A 2qmqA-2dldA:
3.1		 2qmqA-2dldA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		3 / 3 SER A 204
HIS A 215
ASP A 243
 None
 0.61A 2wa2B-2dldA:
4.7		 2wa2B-2dldA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 6 LEU A  66
TYR A  58
ALA A  89
LEU A  36
 None
 0.72A 3ravA-2dldA:
undetectable		 3ravA-2dldA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 8 VAL A  52
LEU A  36
ASN A  83
ILE A  84
 None
 0.90A 3u5kD-2dldA:
undetectable		 3u5kD-2dldA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 7 LEU A  43
ALA A  47
ASP A  48
THR A  32
 None
 0.85A 4eyrA-2dldA:
undetectable		 4eyrA-2dldA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		5 / 10 MET A 165
PHE A 161
ALA A 174
GLY A 158
ALA A 244
 None
 1.23A 4fe1A-2dldA:
undetectable
4fe1J-2dldA:
undetectable		 4fe1A-2dldA:
17.58
4fe1J-2dldA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 8 VAL A  52
LEU A  36
ASN A  83
ILE A  84
 None
 0.90A 4lzrA-2dldA:
undetectable		 4lzrA-2dldA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 7 ASN A  18
GLU A  14
GLU A  13
ARG A  77
 None
 1.09A 4mi4B-2dldA:
undetectable
4mi4C-2dldA:
undetectable		 4mi4B-2dldA:
19.94
4mi4C-2dldA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 8 ASN A  18
GLU A  14
GLU A  13
ARG A  77
 None
 1.10A 4mj8B-2dldA:
undetectable
4mj8C-2dldA:
undetectable		 4mj8B-2dldA:
18.15
4mj8C-2dldA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		5 / 10 LEU A  43
GLY A  46
ALA A  47
ASP A  48
THR A  32
 None
 0.93A 4njtB-2dldA:
undetectable		 4njtB-2dldA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		5 / 9 LEU A  43
GLY A  46
ALA A  47
ASP A  48
THR A  32
 None
 0.94A 4njtD-2dldA:
undetectable		 4njtD-2dldA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 5 VAL A 232
VAL A 149
GLY A 150
PHE A 161
 None
 0.95A 5d4nA-2dldA:
undetectable
5d4nC-2dldA:
undetectable		 5d4nA-2dldA:
17.86
5d4nC-2dldA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2dld D-LACTATE
DEHYDROGENASE
(Lactobacillus
helveticus) 		4 / 4 PRO A  38
MET A  74
GLY A  49
VAL A  52
 None
 1.17A 6ak3A-2dldA:
undetectable		 6ak3A-2dldA:
10.75