SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dlg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dlg FILAMIN-B
(Homo
sapiens) 		3 / 3 GLN A  86
ILE A  25
HIS A  57
 None
 0.68A 1fm9A-2dlgA:
undetectable		 1fm9A-2dlgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 2dlg FILAMIN-B
(Homo
sapiens) 		4 / 6 HIS A  57
ASP A  20
MET A  52
PRO A  51
 None
 1.43A 1ilqA-2dlgA:
undetectable
1ilqC-2dlgA:
undetectable		 1ilqA-2dlgA:
23.00
1ilqC-2dlgA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dlg FILAMIN-B
(Homo
sapiens) 		3 / 3 GLN A  86
ILE A  25
HIS A  57
 None
 0.71A 1k74A-2dlgA:
undetectable		 1k74A-2dlgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2dlg FILAMIN-B
(Homo
sapiens) 		4 / 6 ASN A  22
CYH A  58
ASP A  20
ILE A  18
 None
 1.17A 3w9tB-2dlgA:
undetectable		 3w9tB-2dlgA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2dlg FILAMIN-B
(Homo
sapiens) 		3 / 3 ILE A  25
PRO A  26
ILE A  28
 None
 0.43A 5hw8F-2dlgA:
undetectable		 5hw8F-2dlgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2dlg FILAMIN-B
(Homo
sapiens) 		4 / 6 ILE A  25
VAL A  73
TYR A  75
SER A  83
 None
 0.95A 5jwaH-2dlgA:
undetectable		 5jwaH-2dlgA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dlg FILAMIN-B
(Homo
sapiens) 		3 / 3 GLN A  86
ILE A  25
HIS A  57
 None
 0.69A 5z12B-2dlgA:
undetectable		 5z12B-2dlgA:
19.61