SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		4 / 7 LEU A  95
LEU A  32
VAL A  43
LEU A 110
 None
 0.67A 3g8iA-2dm0A:
undetectable		 3g8iA-2dm0A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		5 / 12 ASN A 102
HIS A 101
PRO A 113
ALA A  40
GLY A  39
 None
 1.31A 3v3oB-2dm0A:
undetectable		 3v3oB-2dm0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		4 / 7 ARG A 109
LEU A 110
ARG A 111
GLY A 105
 None
 0.98A 4cp3A-2dm0A:
undetectable
4cp3B-2dm0A:
undetectable		 4cp3A-2dm0A:
19.86
4cp3B-2dm0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		3 / 3 VAL A  83
TYR A  71
GLN A  72
 None
 0.67A 5qgkA-2dm0A:
undetectable		 5qgkA-2dm0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		3 / 3 VAL A  83
TYR A  71
GLN A  72
 None
 0.67A 5qgrA-2dm0A:
undetectable		 5qgrA-2dm0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		3 / 3 VAL A  83
TYR A  71
GLN A  72
 None
 0.72A 5qgtA-2dm0A:
undetectable		 5qgtA-2dm0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		4 / 7 GLN A  34
GLY A 118
ILE A  42
GLN A 100
 None
 1.16A 5vlmC-2dm0A:
undetectable		 5vlmC-2dm0A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens) 		4 / 6 LYS A  74
GLN A  72
LEU A  95
PHE A  89
 None
 1.35A 6nmpC-2dm0A:
undetectable
6nmpJ-2dm0A:
undetectable		 6nmpC-2dm0A:
15.65
6nmpJ-2dm0A:
16.80