SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 2dm4 SORTILIN-RELATED
RECEPTOR
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  11
TYR A  43
 None
 0.92A 2dxrA-2dm4A:
undetectable		 2dxrA-2dm4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2dm4 SORTILIN-RELATED
RECEPTOR
(Homo
sapiens) 		5 / 11 ALA A  22
GLU A  23
VAL A  27
GLY A 102
ILE A 100
 None
 1.23A 2uxpB-2dm4A:
undetectable		 2uxpB-2dm4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2dm4 SORTILIN-RELATED
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A  14
GLU A  46
VAL A  80
THR A  77
GLY A  51
 None
 1.22A 4q15A-2dm4A:
undetectable		 4q15A-2dm4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2dm4 SORTILIN-RELATED
RECEPTOR
(Homo
sapiens) 		5 / 9 PRO A  19
GLY A 102
ILE A  26
VAL A  72
THR A  99
 None
 1.28A 4x3mA-2dm4A:
undetectable		 4x3mA-2dm4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2dm4 SORTILIN-RELATED
RECEPTOR
(Homo
sapiens) 		5 / 9 PRO A  19
GLY A 102
ILE A  26
LEU A  70
VAL A  72
 None
 1.01A 4x3mB-2dm4A:
undetectable		 4x3mB-2dm4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2dm4 SORTILIN-RELATED
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A  14
GLU A  46
VAL A  80
THR A  77
GLY A  51
 None
 1.17A 5xipA-2dm4A:
undetectable		 5xipA-2dm4A:
12.85