SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 2dmj POLY (ADP-RIBOSE)
POLYMERASE FAMILY,
MEMBER 1
(Homo
sapiens) 		4 / 7 TYR A  59
ARG A  41
VAL A  46
ASP A  13
 None
 0.85A 2y05A-2dmjA:
undetectable
2y05B-2dmjA:
undetectable		 2y05A-2dmjA:
15.72
2y05B-2dmjA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2dmj POLY (ADP-RIBOSE)
POLYMERASE FAMILY,
MEMBER 1
(Homo
sapiens) 		3 / 3 ARG A  41
ASP A  79
ASP A  13
 None
 0.83A 4kicB-2dmjA:
undetectable		 4kicB-2dmjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2dmj POLY (ADP-RIBOSE)
POLYMERASE FAMILY,
MEMBER 1
(Homo
sapiens) 		4 / 6 GLY A  80
GLU A  19
ASP A  88
ASP A  75
 None
 1.05A 4uckB-2dmjA:
undetectable		 4uckB-2dmjA:
13.20