SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		5 / 9 LEU A 131
LEU A  70
ILE A  40
PHE A 106
VAL A  48
 None
 1.45A 3tmzA-2dmmA:
undetectable		 3tmzA-2dmmA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		4 / 6 GLY A 120
GLY A 121
GLU A 119
ILE A 104
 None
 0.93A 4fglD-2dmmA:
undetectable		 4fglD-2dmmA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		3 / 3 VAL A  48
ALA A 109
PHE A 106
 None
 0.75A 4olbA-2dmmA:
undetectable		 4olbA-2dmmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		3 / 3 VAL A  48
ALA A 109
PHE A 106
 None
 0.71A 4w5nA-2dmmA:
undetectable		 4w5nA-2dmmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		5 / 10 LEU A  70
GLY A  71
ASP A  77
SER A  75
ALA A 135
 None
 1.13A 4xj7C-2dmmA:
undetectable
4xj7D-2dmmA:
undetectable		 4xj7C-2dmmA:
17.69
4xj7D-2dmmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		4 / 8 ILE A 104
LEU A  74
ILE A  80
LEU A  63
 None
 0.96A 5ieoA-2dmmA:
undetectable		 5ieoA-2dmmA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2dmm PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens) 		3 / 3 VAL A  48
ALA A 109
PHE A 106
 None
 0.72A 5js1A-2dmmA:
undetectable		 5js1A-2dmmA:
11.11