SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		5 / 9 LEU A 117
LEU A 121
ILE A  10
LEU A  86
ILE A  89
 None
 1.18A 2f78A-2dmwA:
undetectable		 2f78A-2dmwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		5 / 9 LEU A 117
LEU A 121
ILE A  10
LEU A  86
ILE A  89
 None
 1.20A 2f7aA-2dmwA:
undetectable		 2f7aA-2dmwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		4 / 5 GLN A 120
THR A  73
HIS A  60
HIS A 124
 None
 1.41A 3g1uC-2dmwA:
undetectable		 3g1uC-2dmwA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A  85
ALA A  82
THR A  73
 None
 1.06A 3t3sB-2dmwA:
undetectable		 3t3sB-2dmwA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		4 / 8 ASN A  84
PHE A  85
ALA A  82
THR A  73
 None
 1.02A 3t3sE-2dmwA:
undetectable		 3t3sE-2dmwA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		4 / 6 GLN A  94
PHE A  93
PHE A 113
LEU A 117
 None
 1.11A 5z84P-2dmwA:
undetectable
5z84W-2dmwA:
undetectable		 5z84P-2dmwA:
19.11
5z84W-2dmwA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		4 / 6 GLN A  94
PHE A  93
PHE A 113
LEU A 117
 None
 1.07A 5z85P-2dmwA:
undetectable
5z85W-2dmwA:
undetectable		 5z85P-2dmwA:
19.11
5z85W-2dmwA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		4 / 6 GLN A  94
PHE A  93
PHE A 113
LEU A 117
 None
 1.11A 5z86P-2dmwA:
undetectable
5z86W-2dmwA:
undetectable		 5z86P-2dmwA:
19.11
5z86W-2dmwA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2dmw SYNAPTOBREVIN-LIKE 1
VARIANT
(Homo
sapiens) 		5 / 9 LEU A  50
THR A  51
ILE A  62
PHE A  83
ILE A  43
 None
 1.31A 6ebpA-2dmwA:
undetectable		 6ebpA-2dmwA:
22.06