SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRE_X_TOPX300_1 (DIHYDROFOLATE REDUCTASE)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	5 / 9	ALA A 94 LEU A 29 LEU A 100 VAL A 74 ILE A 33	None	1.19A	3freX-2dmzA: undetectable	3freX-2dmzA: 21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HSW_A_ACTA501_0 (ORF 37)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	4 / 5	ARG A 104 SER A 110 SER A 108 SER A 109	None	1.36A	5hswA-2dmzA: undetectable	5hswA-2dmzA: 12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_A_Z80A401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	5 / 11	ILE A 79 ILE A 48 VAL A 74 ASP A 69 ILE A 31	None	1.03A	5lg3A-2dmzA: undetectable	5lg3A-2dmzA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_E_Z80E401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	5 / 12	ILE A 79 ILE A 48 VAL A 74 ASP A 69 ILE A 31	None	1.00A	5lg3E-2dmzA: undetectable	5lg3E-2dmzA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_F_Z80F401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	5 / 10	ILE A 79 ILE A 48 VAL A 74 ASP A 69 ILE A 31	None	1.00A	5lg3F-2dmzA: undetectable	5lg3F-2dmzA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_H_Z80H401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	5 / 10	ILE A 79 ILE A 48 VAL A 74 ASP A 69 ILE A 31	None	1.01A	5lg3H-2dmzA: undetectable	5lg3H-2dmzA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_J_Z80J401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	5 / 12	ILE A 79 ILE A 48 VAL A 74 ASP A 69 ILE A 31	None	1.01A	5lg3J-2dmzA: undetectable	5lg3J-2dmzA: 18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_D_SUED1202_1 (NS3 PROTEASE)	2dmz	INAD-LIKE PROTEIN (Homo sapiens)	4 / 9	VAL A 87 HIS A 85 LEU A 102 VAL A 67	None	0.88A	6c2mD-2dmzA: undetectable	6c2mD-2dmzA: 18.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3FRE_X_TOPX300_1","DIHYDROFOLATE REDUCTASE","2dmz","INAD-LIKE PROTEIN","Homo sapiens",5,"ALA A  94;LEU A  29;LEU A 100;VAL A  74;ILE A  33","None","1.19A","3freX-2dmzA:undetectable","3freX-2dmzA:21.76"],["5HSW_A_ACTA501_0","ORF 37","2dmz","INAD-LIKE PROTEIN","Homo sapiens",4,"ARG A 104;SER A 110;SER A 108;SER A 109","None","1.36A","5hswA-2dmzA:undetectable","5hswA-2dmzA:12.70"],["5LG3_A_Z80A401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","2dmz","INAD-LIKE PROTEIN","Homo sapiens",5,"ILE A  79;ILE A  48;VAL A  74;ASP A  69;ILE A  31","None","1.03A","5lg3A-2dmzA:undetectable","5lg3A-2dmzA:18.82"],["5LG3_E_Z80E401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","2dmz","INAD-LIKE PROTEIN","Homo sapiens",5,"ILE A  79;ILE A  48;VAL A  74;ASP A  69;ILE A  31","None","1.00A","5lg3E-2dmzA:undetectable","5lg3E-2dmzA:18.82"],["5LG3_F_Z80F401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","2dmz","INAD-LIKE PROTEIN","Homo sapiens",5,"ILE A  79;ILE A  48;VAL A  74;ASP A  69;ILE A  31","None","1.00A","5lg3F-2dmzA:undetectable","5lg3F-2dmzA:18.82"],["5LG3_H_Z80H401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","2dmz","INAD-LIKE PROTEIN","Homo sapiens",5,"ILE A  79;ILE A  48;VAL A  74;ASP A  69;ILE A  31","None","1.01A","5lg3H-2dmzA:undetectable","5lg3H-2dmzA:18.82"],["5LG3_J_Z80J401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","2dmz","INAD-LIKE PROTEIN","Homo sapiens",5,"ILE A  79;ILE A  48;VAL A  74;ASP A  69;ILE A  31","None","1.01A","5lg3J-2dmzA:undetectable","5lg3J-2dmzA:18.82"],["6C2M_D_SUED1202_1","NS3 PROTEASE","2dmz","INAD-LIKE PROTEIN","Homo sapiens",4,"VAL A  87;HIS A  85;LEU A 102;VAL A  67","None","0.88A","6c2mD-2dmzA:undetectable","6c2mD-2dmzA:18.80"]]