SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HJH_A_NCAA900_0 (NAD-DEPENDENT HISTONE DEACETYLASE SIR2)	2dn4	GENERAL TRANSCRIPTION FACTOR II-I (Homo sapiens)	4 / 5	ILE A 53 PRO A 54 PHE A 55 ILE A 76	None	1.01A	2hjhA-2dn4A: undetectable	2hjhA-2dn4A: 12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QRC_A_0LIA802_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 4)	2dn4	GENERAL TRANSCRIPTION FACTOR II-I (Homo sapiens)	4 / 8	LEU A 15 VAL A 12 ILE A 53 LEU A 49	None	0.79A	4qrcA-2dn4A: undetectable	4qrcA-2dn4A: 15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ACL_A_SASA1111_1 (MCG)	2dn4	GENERAL TRANSCRIPTION FACTOR II-I (Homo sapiens)	4 / 7	TYR A 45 GLU A 47 PRO A 50 PHE A 37	None	1.17A	5aclA-2dn4A: undetectable	5aclA-2dn4A: 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z84_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2dn4	GENERAL TRANSCRIPTION FACTOR II-I (Homo sapiens)	4 / 5	ILE A 76 PHE A 16 TYR A 61 ARG A 65	None	1.16A	5z84N-2dn4A: undetectable 5z84W-2dn4A: undetectable	5z84N-2dn4A: 12.30 5z84W-2dn4A: 25.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2HJH_A_NCAA900_0","NAD-DEPENDENT HISTONE DEACETYLASE SIR2","2dn4","GENERAL TRANSCRIPTION FACTOR II-I","Homo sapiens",4,"ILE A  53;PRO A  54;PHE A  55;ILE A  76","None","1.01A","2hjhA-2dn4A:undetectable","2hjhA-2dn4A:12.85"],["4QRC_A_0LIA802_2","FIBROBLAST GROWTH FACTOR RECEPTOR 4","2dn4","GENERAL TRANSCRIPTION FACTOR II-I","Homo sapiens",4,"LEU A  15;VAL A  12;ILE A  53;LEU A  49","None","0.79A","4qrcA-2dn4A:undetectable","4qrcA-2dn4A:15.48"],["5ACL_A_SASA1111_1","MCG","2dn4","GENERAL TRANSCRIPTION FACTOR II-I","Homo sapiens",4,"TYR A  45;GLU A  47;PRO A  50;PHE A  37","None","1.17A","5aclA-2dn4A:undetectable","5aclA-2dn4A:23.14"],["5Z84_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2dn4","GENERAL TRANSCRIPTION FACTOR II-I","Homo sapiens",4,"ILE A  76;PHE A  16;TYR A  61;ARG A  65","None","1.16A","5z84N-2dn4A:undetectable;5z84W-2dn4A:undetectable","5z84N-2dn4A:12.30;5z84W-2dn4A:25.84"]]