SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dnc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 2dnc PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT
(Homo
sapiens) 		5 / 12 ALA A  55
ASP A  57
ILE A   8
ILE A  79
VAL A  35
 None
 0.73A 2b7zA-2dncA:
undetectable		 2b7zA-2dncA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 2dnc PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT
(Homo
sapiens) 		5 / 12 ALA A  55
ASP A  57
ILE A   8
ILE A  79
VAL A  35
 None
 0.75A 2b7zB-2dncA:
undetectable		 2b7zB-2dncA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 2dnc PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT
(Homo
sapiens) 		4 / 5 LEU A  53
ILE A  79
LEU A  78
SER A  77
 None
 0.66A 2byoA-2dncA:
undetectable		 2byoA-2dncA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 2dnc PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT
(Homo
sapiens) 		5 / 12 ALA A  55
ASP A  57
ILE A   8
ILE A  79
VAL A  35
 None
 0.69A 2nnkA-2dncA:
undetectable		 2nnkA-2dncA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 2dnc PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT
(Homo
sapiens) 		5 / 12 ALA A  55
ASP A  57
ILE A   8
ILE A  79
VAL A  35
 None
 0.67A 3el4A-2dncA:
undetectable		 3el4A-2dncA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 2dnc PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT
(Homo
sapiens) 		5 / 10 ALA A  55
ASP A  57
ILE A   8
GLY A  80
ILE A  64
 None
 1.00A 5kr1A-2dncA:
undetectable		 5kr1A-2dncA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2dnc PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT
(Homo
sapiens) 		5 / 12 ALA A  55
ASP A  57
ILE A   8
ILE A  79
VAL A  35
 None
 0.77A 6dh0A-2dncA:
undetectable		 6dh0A-2dncA:
19.39