SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I7Z_C_COCC302_2 (CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION)	2dng	EUKARYOTIC TRANSLATION INITIATION FACTOR 4H (Mus musculus)	4 / 4	GLU A 90 TYR A 41 PRO A 40 ASP A 89	None	1.46A	1i7zD-2dngA: 0.5	1i7zD-2dngA: 21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F8H_B_RKEB401_1 (PROTON-GATED ION CHANNEL)	2dng	EUKARYOTIC TRANSLATION INITIATION FACTOR 4H (Mus musculus)	4 / 8	ASP A 56 VAL A 45 PHE A 80 LEU A 71	None	1.09A	4f8hB-2dngA: undetectable 4f8hC-2dngA: undetectable	4f8hB-2dngA: 16.77 4f8hC-2dngA: 16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OF1_A_SALA301_1 (SPORE COAT-ASSOCIATED PROTEIN N)	2dng	EUKARYOTIC TRANSLATION INITIATION FACTOR 4H (Mus musculus)	4 / 5	ALA A 43 VAL A 45 PHE A 88 ILE A 57	None	0.80A	5of1A-2dngA: undetectable	5of1A-2dngA: 27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OF1_B_SALB301_1 (SPORE COAT-ASSOCIATED PROTEIN N)	2dng	EUKARYOTIC TRANSLATION INITIATION FACTOR 4H (Mus musculus)	4 / 5	ALA A 43 VAL A 45 PHE A 88 ILE A 57	None	0.83A	5of1B-2dngA: undetectable	5of1B-2dngA: 27.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I7Z_C_COCC302_2","CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION;CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION","2dng","EUKARYOTIC TRANSLATION INITIATION FACTOR 4H","Mus musculus",4,"GLU A  90;TYR A  41;PRO A  40;ASP A  89","None","1.46A","1i7zD-2dngA:0.5","1i7zD-2dngA:21.50"],["4F8H_B_RKEB401_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","2dng","EUKARYOTIC TRANSLATION INITIATION FACTOR 4H","Mus musculus",4,"ASP A  56;VAL A  45;PHE A  80;LEU A  71","None","1.09A","4f8hB-2dngA:undetectable;4f8hC-2dngA:undetectable","4f8hB-2dngA:16.77;4f8hC-2dngA:16.77"],["5OF1_A_SALA301_1","SPORE COAT-ASSOCIATED PROTEIN N","2dng","EUKARYOTIC TRANSLATION INITIATION FACTOR 4H","Mus musculus",4,"ALA A  43;VAL A  45;PHE A  88;ILE A  57","None","0.80A","5of1A-2dngA:undetectable","5of1A-2dngA:27.52"],["5OF1_B_SALB301_1","SPORE COAT-ASSOCIATED PROTEIN N","2dng","EUKARYOTIC TRANSLATION INITIATION FACTOR 4H","Mus musculus",4,"ALA A  43;VAL A  45;PHE A  88;ILE A  57","None","0.83A","5of1B-2dngA:undetectable","5of1B-2dngA:27.52"]]