SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2do8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		5 / 12 GLN A  70
VAL A  72
ARG A  23
LEU A  52
THR A  54
 None
 1.22A 2q7kA-2do8A:
undetectable		 2q7kA-2do8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		4 / 4 THR A  45
VAL A  49
GLY A  83
THR A 108
 None
 1.10A 3cflA-2do8A:
undetectable		 3cflA-2do8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		4 / 8 PHE A  21
GLY A 175
SER A 177
ILE A 176
 None
 0.73A 3ihzB-2do8A:
undetectable		 3ihzB-2do8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		4 / 4 GLY A 130
GLY A  83
THR A 108
LEU A 106
 None
 0.81A 3si7C-2do8A:
undetectable
3si7D-2do8A:
undetectable		 3si7C-2do8A:
21.00
3si7D-2do8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		3 / 3 LEU A 158
MET A 173
TYR A 163
 None
 0.82A 4p6xG-2do8A:
undetectable		 4p6xG-2do8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		4 / 4 CYH A 128
PHE A  84
ILE A  40
GLY A  76
 None
 1.24A 5hesB-2do8A:
0.0		 5hesB-2do8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		5 / 12 ALA A 170
THR A 101
GLY A   7
SER A 151
GLU A 152
 None
 1.32A 5hfjG-2do8A:
undetectable		 5hfjG-2do8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		5 / 10 TYR A 163
ILE A  26
ILE A  40
ILE A 104
ASN A 155
 None
 1.44A 5vkqA-2do8A:
undetectable
5vkqD-2do8A:
undetectable		 5vkqA-2do8A:
7.69
5vkqD-2do8A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		5 / 10 ILE A 104
ASN A 155
TYR A 163
ILE A  26
ILE A  40
 None
 1.43A 5vkqA-2do8A:
undetectable
5vkqB-2do8A:
undetectable		 5vkqA-2do8A:
7.69
5vkqB-2do8A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2do8 UPF0301 PROTEIN
HD_1794
([Haemophilus]
ducreyi) 		5 / 10 ILE A 104
ASN A 155
TYR A 163
ILE A  26
ILE A  40
 None
 1.41A 5vkqC-2do8A:
undetectable
5vkqD-2do8A:
undetectable		 5vkqC-2do8A:
7.69
5vkqD-2do8A:
7.69