SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2doi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2doi ANGIOSTATIN
(Homo
sapiens) 		4 / 7 TRP X 225
PHE X 227
ARG X 234
TRP X 235
 None
 1.30A 1b2iA-2doiX:
13.0		 1b2iA-2doiX:
61.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2doi ANGIOSTATIN
(Homo
sapiens) 		6 / 7 TYR X 200
ASP X 219
GLU X 221
TRP X 225
PHE X 227
TRP X 235
 None
 0.94A 1b2iA-2doiX:
13.0		 1b2iA-2doiX:
61.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		6 / 8 ASP X 137
ASP X 139
TRP X 144
TYR X 146
ARG X 153
TYR X 154
 None
 0.57A 1ceaA-2doiX:
undetectable
1ceaB-2doiX:
17.2		 1ceaA-2doiX:
100.00
1ceaB-2doiX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		6 / 7 ASP X 137
ASP X 139
TRP X 144
TYR X 146
ARG X 153
TYR X 154
 None
 0.54A 1ceaB-2doiX:
17.2		 1ceaB-2doiX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		6 / 7 ASP X 137
ASP X 139
TRP X 144
TYR X 146
ARG X 153
TYR X 154
 None
 0.59A 1cebA-2doiX:
17.1		 1cebA-2doiX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		6 / 7 ASP X 137
ASP X 139
TRP X 144
TYR X 146
ARG X 153
TYR X 154
 None
 0.60A 1cebB-2doiX:
17.1		 1cebB-2doiX:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		3 / 3 PHE X 227
TRP X 225
GLU X 221
 None
 1.07A 1mogA-2doiX:
undetectable		 1mogA-2doiX:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 2doi ANGIOSTATIN
(Homo
sapiens) 		4 / 7 ASP X 137
ASP X 139
TRP X 144
ARG X 153
 None
 0.34A 2pk4A-2doiX:
15.5		 2pk4A-2doiX:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 2doi ANGIOSTATIN
(Homo
sapiens) 		4 / 7 ASP X 219
TRP X 225
PHE X 227
TRP X 235
 None
 0.73A 2pk4A-2doiX:
15.5		 2pk4A-2doiX:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 2doi ANGIOSTATIN
(Homo
sapiens) 		4 / 7 TRP X 225
PHE X 227
ARG X 234
TRP X 235
 None
 0.73A 2pk4A-2doiX:
15.5		 2pk4A-2doiX:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		4 / 7 ASP X 137
ASP X 139
TRP X 144
ARG X 153
 None
 0.29A 3kivA-2doiX:
15.5		 3kivA-2doiX:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		4 / 7 ASP X 219
TRP X 225
PHE X 227
TRP X 235
 None
 0.65A 3kivA-2doiX:
15.5		 3kivA-2doiX:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		4 / 7 TRP X 225
PHE X 227
ARG X 234
TRP X 235
 None
 0.57A 3kivA-2doiX:
15.5		 3kivA-2doiX:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 2doi ANGIOSTATIN
(Homo
sapiens) 		5 / 10 TYR X  92
ASP X 155
THR X  99
GLY X 142
ASP X 139
 None
 1.50A 6mb9D-2doiX:
undetectable		 6mb9D-2doiX:
16.82