SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 PHE A 241
LEU A  91
ALA A  90
LEU A 275
PHE A  68
 None
 1.03A 1og5B-2douA:
undetectable		 1og5B-2douA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 ALA A 127
TYR A 124
ILE A 195
ASP A 197
 None
EPE  A 501 (-4.9A)
None
EPE  A 501 (-3.5A)
 0.78A 1upfB-2douA:
3.9		 1upfB-2douA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 SER A   8
PHE A  10
ALA A 340
ASP A 324
 None
 0.91A 2bxkA-2douA:
undetectable		 2bxkA-2douA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 186
ARG A 141
PRO A 212
GLY A 178
 None
 1.08A 2qd5A-2douA:
undetectable		 2qd5A-2douA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 TRP A  75
GLY A 244
GLY A  81
PHE A 226
 None
 0.94A 2qwxA-2douA:
2.3
2qwxB-2douA:
2.2		 2qwxA-2douA:
20.00
2qwxB-2douA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A 319
VAL A 323
GLY A 322
GLY A 317
LEU A 304
 None
 0.76A 2v3kA-2douA:
undetectable		 2v3kA-2douA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 357
LEU A 361
ALA A 367
LEU A 365
ALA A 299
 None
SO4  A 502 (-4.3A)
None
None
None
 0.99A 2vcvD-2douA:
undetectable		 2vcvD-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 357
LEU A 361
ALA A 367
LEU A 365
ALA A 299
 None
SO4  A 502 (-4.3A)
None
None
None
 1.02A 2vcvE-2douA:
undetectable		 2vcvE-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 100
ALA A 242
LEU A 252
ALA A 248
 None
 0.91A 2vcvF-2douA:
undetectable		 2vcvF-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 228
LEU A 239
LEU A  47
ALA A  46
 None
 0.79A 2vcvF-2douA:
undetectable		 2vcvF-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 357
LEU A 361
ALA A 367
LEU A 365
ALA A 299
 None
SO4  A 502 (-4.3A)
None
None
None
 1.07A 2vcvH-2douA:
undetectable		 2vcvH-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 357
LEU A 361
ALA A 367
LEU A 365
ALA A 299
 None
SO4  A 502 (-4.3A)
None
None
None
 0.98A 2vcvI-2douA:
undetectable		 2vcvI-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 357
ALA A 367
LEU A 365
ALA A 299
 None
 0.95A 2vcvK-2douA:
undetectable		 2vcvK-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 228
LEU A 239
LEU A  47
ALA A  46
 None
 0.80A 2vcvP-2douA:
undetectable		 2vcvP-2douA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 HIS A 196
ALA A 175
ALA A 173
THR A 171
 None
 1.06A 2xfhA-2douA:
undetectable		 2xfhA-2douA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 TYR A  80
GLU A 224
ASN A 165
 None
None
EPE  A 501 ( 4.2A)
 1.02A 2y7hC-2douA:
2.4		 2y7hC-2douA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 PHE A 125
GLY A 126
VAL A 130
ALA A 131
LEU A 163
 None
 1.35A 3a3yA-2douA:
undetectable		 3a3yA-2douA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ASP A 202
ASP A 176
TRP A 177
TYR A  80
 None
 1.21A 3havA-2douA:
undetectable		 3havA-2douA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 375
ARG A 335
GLY A 322
PRO A 320
 None
 0.91A 3ny4A-2douA:
undetectable		 3ny4A-2douA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 VAL A 201
SER A 211
PHE A 241
PHE A 226
TYR A 232
 None
 1.43A 3nyaA-2douA:
undetectable		 3nyaA-2douA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A 162
LEU A 115
PRO A 139
ILE A 138
 None
 0.73A 3s56B-2douA:
undetectable		 3s56B-2douA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 LEU A 243
GLY A 244
LEU A 249
GLU A  89
 None
 1.11A 3tgvB-2douA:
undetectable		 3tgvB-2douA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 361
LEU A 339
LEU A 357
ALA A 367
LEU A 365
 SO4  A 502 (-4.3A)
None
None
None
None
 1.34A 4m11A-2douA:
undetectable		 4m11A-2douA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A 260
LYS A  62
LEU A  69
 None
 1.05A 4ptjA-2douA:
undetectable		 4ptjA-2douA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ALA A 367
ALA A 368
ILE A 371
LEU A 304
 None
 0.49A 4v1fA-2douA:
undetectable
4v1fB-2douA:
undetectable		 4v1fA-2douA:
12.77
4v1fB-2douA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 LEU A 104
ALA A 127
LEU A 100
ALA A 120
LEU A 114
 None
 0.95A 4z90A-2douA:
undetectable
4z90B-2douA:
undetectable
4z90C-2douA:
undetectable
4z90D-2douA:
undetectable
4z90E-2douA:
undetectable		 4z90A-2douA:
23.15
4z90B-2douA:
23.15
4z90C-2douA:
23.15
4z90D-2douA:
23.15
4z90E-2douA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 LEU A 114
LEU A 104
ALA A 127
LEU A 100
ALA A 120
 None
 0.95A 4z90A-2douA:
undetectable
4z90B-2douA:
undetectable
4z90C-2douA:
undetectable
4z90D-2douA:
undetectable
4z90E-2douA:
undetectable		 4z90A-2douA:
23.15
4z90B-2douA:
23.15
4z90C-2douA:
23.15
4z90D-2douA:
23.15
4z90E-2douA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 7 LEU A 104
ALA A 127
LEU A 100
ALA A 120
LEU A 114
 None
 0.92A 4z90F-2douA:
undetectable
4z90G-2douA:
undetectable
4z90H-2douA:
undetectable
4z90J-2douA:
undetectable		 4z90F-2douA:
23.15
4z90G-2douA:
23.15
4z90H-2douA:
23.15
4z90J-2douA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLY A 342
ASP A 325
ARG A 343
GLY A 346
 None
 0.66A 5cdnA-2douA:
1.2
5cdnB-2douA:
undetectable		 5cdnA-2douA:
22.65
5cdnB-2douA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLY A 342
ASP A 325
ARG A 343
GLY A 346
 None
 0.87A 5cdnC-2douA:
undetectable
5cdnD-2douA:
undetectable		 5cdnC-2douA:
22.65
5cdnD-2douA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLY A 342
ASP A 325
ARG A 343
GLY A 346
 None
 0.88A 5cdnT-2douA:
undetectable
5cdnU-2douA:
undetectable		 5cdnT-2douA:
22.65
5cdnU-2douA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA611_0
(SERUM ALBUMIN)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 LYS A  17
SER A  31
LEU A  30
ALA A 338
 None
 0.90A 5dbyA-2douA:
0.0		 5dbyA-2douA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 LEU A 239
GLY A 240
SER A 227
SER A 229
 None
None
SO4  A 503 (-2.7A)
SO4  A 503 (-2.6A)
 1.30A 5uunA-2douA:
undetectable		 5uunA-2douA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 LEU A 239
GLY A 240
SER A 227
SER A 229
 None
None
SO4  A 503 (-2.7A)
SO4  A 503 (-2.6A)
 1.30A 5uunB-2douA:
undetectable		 5uunB-2douA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 VAL A 151
LEU A 186
LEU A 192
HIS A 190
ALA A 159
 None
 1.42A 5xprA-2douA:
undetectable		 5xprA-2douA:
22.54