SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 PRO A 298
LEU A 285
LEU A 269
LEU A 236
ASP A 217
 NAD  A1403 (-4.8A)
None
None
NAD  A1403 (-4.7A)
NAD  A1403 (-2.9A)
 1.40A 1e7wA-2dphA:
7.9		 1e7wA-2dphA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 6 ALA A 202
SER A 168
ARG A 222
LEU A 226
 None
None
NAD  A1403 (-3.0A)
None
 1.20A 1gahA-2dphA:
undetectable		 1gahA-2dphA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 ASP A 287
ASP A 321
LYS A 328
 None
 0.92A 1lqtB-2dphA:
3.8		 1lqtB-2dphA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 ASP A 287
ASP A 321
LYS A 328
 None
 0.93A 1lquB-2dphA:
2.2		 1lquB-2dphA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 223
VAL A 288
LEU A 236
LEU A 242
LEU A 285
 None
None
NAD  A1403 (-4.7A)
None
None
 1.09A 1mx1E-2dphA:
undetectable		 1mx1E-2dphA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 11 ARG A 206
GLY A 174
ASP A 260
GLY A 195
ILE A 191
 None
None
None
NAD  A1403 (-3.2A)
None
 0.90A 1n49C-2dphA:
undetectable		 1n49C-2dphA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 ILE A 295
ILE A 330
THR A 334
 None
 0.63A 1rg7A-2dphA:
3.0		 1rg7A-2dphA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 1rl8A-2dphA:
undetectable		 1rl8A-2dphA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 ASP A 169
VAL A  90
PRO A 142
 ZN  A1002 ( 2.7A)
None
None
 0.74A 2avvA-2dphA:
undetectable		 2avvA-2dphA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 2avvB-2dphA:
undetectable		 2avvB-2dphA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 1.11A 2aylA-2dphA:
undetectable		 2aylA-2dphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.43A 2f81B-2dphA:
undetectable		 2f81B-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.47A 2ienA-2dphA:
undetectable		 2ienA-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.43A 2ienB-2dphA:
undetectable		 2ienB-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 8 ALA A 181
LEU A 285
ILE A 330
VAL A 288
ILE A 246
 None
 1.40A 2uxpA-2dphA:
undetectable		 2uxpA-2dphA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.44A 3bvbB-2dphA:
undetectable		 3bvbB-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 HIS A  26
ASN A  27
ASP A 127
VAL A  94
TYR A 143
 None
 1.47A 3cb8A-2dphA:
2.7		 3cb8A-2dphA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 3cywA-2dphA:
undetectable		 3cywA-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 3cywB-2dphA:
undetectable		 3cywB-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 3d1zB-2dphA:
undetectable		 3d1zB-2dphA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.43A 3d20B-2dphA:
undetectable		 3d20B-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 8 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.50A 3ekpA-2dphA:
undetectable		 3ekpA-2dphA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 10 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 3ekpD-2dphA:
undetectable		 3ekpD-2dphA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 11 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.46A 3ektC-2dphA:
undetectable		 3ektC-2dphA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 11 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.46A 3ektD-2dphA:
undetectable		 3ektD-2dphA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 10 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.47A 3ekvA-2dphA:
undetectable		 3ekvA-2dphA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.47A 3jw2A-2dphA:
undetectable		 3jw2A-2dphA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.48A 3jw2B-2dphA:
undetectable		 3jw2B-2dphA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.47A 3k4vB-2dphA:
undetectable		 3k4vB-2dphA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.46A 3lzuA-2dphA:
undetectable		 3lzuA-2dphA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 3lzuB-2dphA:
undetectable		 3lzuB-2dphA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.96A 3n8xA-2dphA:
undetectable		 3n8xA-2dphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 1.06A 3n8xB-2dphA:
undetectable		 3n8xB-2dphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.97A 3n8zB-2dphA:
undetectable		 3n8zB-2dphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.84A 3nt1A-2dphA:
undetectable		 3nt1A-2dphA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.84A 3nt1B-2dphA:
undetectable		 3nt1B-2dphA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 11 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.50A 3nu3B-2dphA:
undetectable		 3nu3B-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 9 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 3nuoB-2dphA:
undetectable		 3nuoB-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 TYR A 301
GLY A 299
GLY A  46
SER A  47
ALA A 192
 None
NAD  A1403 ( 3.7A)
NAD  A1403 (-3.2A)
NAD  A1403 (-2.6A)
NAD  A1403 ( 3.6A)
 1.06A 3ou7B-2dphA:
6.2		 3ou7B-2dphA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 GLY A 296
ARG A 206
GLY A 182
ALA A 205
ALA A 210
 None
 1.07A 3sudA-2dphA:
undetectable		 3sudA-2dphA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 GLY A 296
ARG A 206
GLY A 182
ALA A 205
ALA A 210
 None
 1.15A 3sueB-2dphA:
undetectable		 3sueB-2dphA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.41A 3tkwA-2dphA:
undetectable		 3tkwA-2dphA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.40A 3tkwB-2dphA:
undetectable		 3tkwB-2dphA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.41A 3tl9B-2dphA:
undetectable		 3tl9B-2dphA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 8 GLY A 133
GLY A  65
ILE A 389
LEU A 369
VAL A  39
 None
 1.42A 3v1nA-2dphA:
undetectable		 3v1nA-2dphA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 9 ALA A 273
LEU A 236
ASP A 217
ASN A 219
ILE A 234
 None
NAD  A1403 (-4.7A)
NAD  A1403 (-2.9A)
None
None
 1.23A 3wdmA-2dphA:
2.4		 3wdmA-2dphA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 6 LEU A 320
PHE A 322
PHE A 286
LEU A 282
 None
 1.05A 3wg7C-2dphA:
undetectable
3wg7J-2dphA:
undetectable		 3wg7C-2dphA:
19.30
3wg7J-2dphA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 7 ILE A 170
GLU A  67
PHE A  92
VAL A  58
 None
ZN  A1002 ( 4.6A)
NAD  A1403 (-4.2A)
None
 1.09A 4a97A-2dphA:
undetectable		 4a97A-2dphA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 7 ILE A 170
GLU A  67
PHE A  92
VAL A  58
 None
ZN  A1002 ( 4.6A)
NAD  A1403 (-4.2A)
None
 1.06A 4a97D-2dphA:
undetectable		 4a97D-2dphA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.43A 4jecA-2dphA:
undetectable		 4jecA-2dphA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 VAL A 179
GLY A 182
LYS A 184
 None
 0.65A 4k50A-2dphA:
undetectable		 4k50A-2dphA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 VAL A 179
GLY A 182
LYS A 184
 None
 0.57A 4k50E-2dphA:
undetectable		 4k50E-2dphA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 VAL A 179
GLY A 182
LYS A 184
 None
 0.64A 4k50I-2dphA:
undetectable		 4k50I-2dphA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 10 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 4ll3B-2dphA:
undetectable		 4ll3B-2dphA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 10 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.45A 4ll3A-2dphA:
undetectable		 4ll3A-2dphA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 ALA A 210
ILE A 249
ILE A 246
LEU A 250
VAL A 255
 None
 1.00A 4nkvB-2dphA:
undetectable		 4nkvB-2dphA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 PRO A  20
VAL A  63
HIS A  62
 None
 0.78A 4pevC-2dphA:
3.1		 4pevC-2dphA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 9 LEU A 148
GLY A  70
VAL A 141
VAL A  35
LEU A  24
 None
 1.22A 4qd3A-2dphA:
undetectable		 4qd3A-2dphA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 MET A 325
ILE A 330
VAL A 262
LEU A 318
LEU A 320
 None
None
NAD  A1403 (-3.8A)
None
None
 1.20A 4qztA-2dphA:
undetectable		 4qztA-2dphA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.87A 4rrwA-2dphA:
undetectable		 4rrwA-2dphA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.86A 4rrwC-2dphA:
undetectable		 4rrwC-2dphA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.87A 4rrzA-2dphA:
undetectable		 4rrzA-2dphA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.86A 4rrzC-2dphA:
undetectable		 4rrzC-2dphA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 GLY A  65
SER A 132
ILE A  44
ASN A  43
TYR A  52
 None
 1.31A 4rtpA-2dphA:
4.5		 4rtpA-2dphA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 5 ASP A  48
VAL A  58
PHE A  56
GLY A  54
 None
 1.09A 4xp6A-2dphA:
undetectable		 4xp6A-2dphA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 5 GLN A 135
ILE A  44
ILE A 367
TYR A 376
 None
 1.17A 5dnuA-2dphA:
undetectable		 5dnuA-2dphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 5 GLN A 135
ILE A  44
ILE A 367
TYR A 376
 None
 1.16A 5dnvA-2dphA:
undetectable		 5dnvA-2dphA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 ALA A 202
PHE A 126
ILE A  51
GLY A  65
THR A  42
 None
 1.21A 5eshA-2dphA:
undetectable		 5eshA-2dphA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.98A 5ikrA-2dphA:
undetectable		 5ikrA-2dphA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 LEU A 236
TYR A 190
SER A 284
 NAD  A1403 (-4.7A)
None
None
 0.88A 5iktA-2dphA:
undetectable		 5iktA-2dphA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 ASN A 112
TYR A 143
CYH A 102
 None
None
ZN  A1001 (-2.3A)
 1.00A 5lsuB-2dphA:
undetectable		 5lsuB-2dphA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.49A 5t2zB-2dphA:
undetectable		 5t2zB-2dphA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		3 / 3 GLY A 382
THR A 173
PRO A 196
 None
NAD  A1403 (-3.0A)
NAD  A1403 ( 4.0A)
 0.61A 5v5zA-2dphA:
undetectable		 5v5zA-2dphA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 ALA A 281
GLY A 268
ASP A 260
ILE A 297
GLY A 198
 NAD  A1403 ( 4.0A)
None
None
None
None
 1.20A 5wwsB-2dphA:
6.1		 5wwsB-2dphA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 GLY A 193
GLY A 198
ILE A 246
VAL A 213
GLY A 216
 NAD  A1403 (-3.4A)
None
None
None
None
 1.00A 5wyqA-2dphA:
undetectable		 5wyqA-2dphA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 5 LEU A 320
PHE A 322
PHE A 286
LEU A 282
 None
 1.13A 5x1bP-2dphA:
undetectable		 5x1bP-2dphA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		5 / 12 VAL A 361
MET A 362
GLY A 198
ALA A 261
LEU A 285
 None
 1.42A 5x23A-2dphA:
undetectable		 5x23A-2dphA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		6 / 12 GLY A 174
ALA A 201
VAL A 189
GLY A 296
ILE A 297
ILE A 191
 None
 1.48A 6dilB-2dphA:
undetectable		 6dilB-2dphA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2dph FORMALDEHYDE
DISMUTASE
(Pseudomonas
putida) 		4 / 8 ASP A 260
TYR A 301
GLY A 314
ASN A 279
 None
 0.99A 6giqL-2dphA:
undetectable
6giqP-2dphA:
undetectable
6giqT-2dphA:
undetectable		 6giqL-2dphA:
23.17
6giqP-2dphA:
21.36
6giqT-2dphA:
10.63