SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 12 ASN A  54
PHE A  88
LEU A  91
ALA A  90
VAL A 209
 None
 1.14A 1xdkA-2dplA:
undetectable		 1xdkA-2dplA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		4 / 6 LEU A  48
ILE A 158
VAL A  18
ALA A  23
 None
 1.03A 2j5mA-2dplA:
undetectable		 2j5mA-2dplA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 12 LEU A 178
GLY A  30
VAL A 169
ILE A 129
GLY A 127
 None
 0.87A 2o4lB-2dplA:
undetectable		 2o4lB-2dplA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		4 / 7 PHE A  52
SER A  34
ILE A 182
GLY A 190
 None
 0.68A 2v0mC-2dplA:
undetectable		 2v0mC-2dplA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 12 ASN A  54
PHE A  88
LEU A  91
ALA A  90
VAL A 209
 None
 1.08A 3dzyA-2dplA:
undetectable		 3dzyA-2dplA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 10 ALA A 232
VAL A 293
ILE A 279
VAL A 290
ILE A 253
 None
 1.02A 3nujA-2dplA:
undetectable		 3nujA-2dplA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 12 PHE A 231
VAL A 258
ARG A 101
VAL A 195
ARG A 196
 None
 1.20A 3p6gA-2dplA:
undetectable		 3p6gA-2dplA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		4 / 6 LEU A 157
ALA A  36
LEU A 161
THR A 128
 None
 1.01A 3rozA-2dplA:
3.6		 3rozA-2dplA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 12 ILE A 182
ALA A 173
ALA A  36
LEU A  27
ILE A  25
 None
 1.07A 4lnwA-2dplA:
undetectable		 4lnwA-2dplA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 12 ILE A 182
ALA A 173
ALA A  36
LEU A  27
ILE A  25
 None
 1.06A 4lnxA-2dplA:
undetectable		 4lnxA-2dplA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		4 / 6 ILE A 125
GLY A 127
ILE A 182
LEU A  48
 None
 0.72A 4o8fB-2dplA:
undetectable		 4o8fB-2dplA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		4 / 6 LEU A 225
GLU A 259
ILE A 279
PRO A 187
 None
 1.10A 4xi3C-2dplA:
undetectable		 4xi3C-2dplA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 10 SER A  28
LEU A  48
ILE A 125
SER A  34
GLY A 127
 None
 1.35A 6dlzA-2dplA:
undetectable
6dlzD-2dplA:
2.1		 6dlzA-2dplA:
14.01
6dlzD-2dplA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B
(Pyrococcus
horikoshii) 		5 / 10 SER A  28
LEU A  48
ILE A 125
SER A  34
GLY A 127
 None
 1.36A 6dm1A-2dplA:
undetectable
6dm1D-2dplA:
2.1		 6dm1A-2dplA:
14.01
6dm1D-2dplA:
14.01