SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DTL_A_BEPA204_1 (CARDIAC TROPONIN C)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 11	ILE A 173 LEU A 81 VAL A 44 LEU A 125 LEU A 122	None	0.94A	1dtlA-2dpmA: undetectable	1dtlA-2dpmA: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K6C_B_MK1B902_2 (POL POLYPROTEIN)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	GLY A 233 ALA A 234 ASP A 189 VAL A 191 VAL A 236	None	0.92A	1k6cB-2dpmA: undetectable	1k6cB-2dpmA: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MUI_B_AB1B100_2 (PROTEASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	GLY A 47 ASP A 62 ILE A 68 ILE A 74 ILE A 60	SAM A 300 (-4.5A) SAM A 300 (-2.8A) None None None	0.89A	1muiB-2dpmA: undetectable	1muiB-2dpmA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	ASP A 177 PRO A 196 LYS A 21 PHE A 43 GLY A 45	SAM A 300 (-4.1A) SAM A 300 ( 4.1A) SAM A 300 (-4.8A) SAM A 300 (-4.2A) SAM A 300 (-3.6A)	1.08A	1nw5A-2dpmA: 3.2	1nw5A-2dpmA: 21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_1 (SUN PROTEIN)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	PRO A 42 ASP A 62 ASP A 177	None SAM A 300 (-2.8A) SAM A 300 (-4.1A)	0.77A	1sqfA-2dpmA: 8.1	1sqfA-2dpmA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T7J_A_478A200_1 (POL POLYPROTEIN)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 11	GLY A 233 ALA A 234 ASP A 189 VAL A 191 VAL A 236	None	0.87A	1t7jA-2dpmA: undetectable	1t7jA-2dpmA: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3A_A_TEPA1436_1 (CHITINASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	ASP A 218 PHE A 178 ARG A 221	None	0.90A	2a3aA-2dpmA: undetectable	2a3aA-2dpmA: 20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2DPM_A_SAMA300_0 (PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	8 / 12	GLY A 20 LYS A 21 GLY A 45 GLY A 46 ALA A 48 ASP A 177 PHE A 178 PRO A 195	SAM A 300 (-3.3A) SAM A 300 (-4.8A) SAM A 300 (-3.6A) SAM A 300 (-3.3A) SAM A 300 (-3.5A) SAM A 300 (-4.1A) None None	1.45A	2dpmA-2dpmA: 43.8	2dpmA-2dpmA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2DPM_A_SAMA300_0 (PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	9 / 12	GLY A 20 LYS A 21 PHE A 43 GLY A 45 GLY A 47 PHE A 63 ASP A 177 PHE A 178 PRO A 196	SAM A 300 (-3.3A) SAM A 300 (-4.8A) SAM A 300 (-4.2A) SAM A 300 (-3.6A) SAM A 300 (-4.5A) None SAM A 300 (-4.1A) None SAM A 300 ( 4.1A)	0.93A	2dpmA-2dpmA: 43.8	2dpmA-2dpmA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2DPM_A_SAMA300_0 (PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	8 / 12	TRP A 17 GLY A 19 PHE A 43 GLY A 45 PHE A 63 ASN A 64 ASP A 177 PHE A 178	SAM A 300 (-4.3A) SAM A 300 (-4.4A) SAM A 300 (-4.2A) SAM A 300 (-3.6A) None None SAM A 300 (-4.1A) None	0.89A	2dpmA-2dpmA: 43.8	2dpmA-2dpmA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2DPM_A_SAMA300_0 (PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	12 / 12	TRP A 17 GLY A 20 LYS A 21 PHE A 43 GLY A 45 GLY A 46 ALA A 48 PHE A 63 ASN A 64 ASP A 177 PHE A 178 PRO A 196	SAM A 300 (-4.3A) SAM A 300 (-3.3A) SAM A 300 (-4.8A) SAM A 300 (-4.2A) SAM A 300 (-3.6A) SAM A 300 (-3.3A) SAM A 300 (-3.5A) None None SAM A 300 (-4.1A) None SAM A 300 ( 4.1A)	0.03A	2dpmA-2dpmA: 43.8	2dpmA-2dpmA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GVC_B_MMZB501_1 (MONOOXYGENASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	ASN A 240 TYR A 209 SER A 243	None	0.74A	2gvcB-2dpmA: undetectable	2gvcB-2dpmA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GVC_E_MMZE501_1 (MONOOXYGENASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	ASN A 240 TYR A 209 SER A 243	None	0.68A	2gvcE-2dpmA: undetectable	2gvcE-2dpmA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_A_SAMA1001_1 (SAM DEPENDENT METHYLTRANSFERASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	ASP A 62 ASP A 177 ASP A 194	SAM A 300 (-2.8A) SAM A 300 (-4.1A) SAM A 300 (-3.7A)	0.27A	2igtA-2dpmA: 10.1	2igtA-2dpmA: 23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_1 (SAM DEPENDENT METHYLTRANSFERASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	ASP A 62 ASP A 177 ASP A 194	SAM A 300 (-2.8A) SAM A 300 (-4.1A) SAM A 300 (-3.7A)	0.30A	2igtB-2dpmA: 10.0	2igtB-2dpmA: 23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M2P_B_DHIB24_0 (INSULIN B CHAIN)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	TYR A 36 GLY A 188 PHE A 190	None	0.43A	2m2pB-2dpmA: undetectable	2m2pB-2dpmA: 10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2MJI_A_KTRA201_1 (FATTY ACID-BINDING PROTEIN, INTESTINAL)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	TYR A 192 LYS A 21 GLU A 276 TYR A 197 LEU A 222	None SAM A 300 (-4.8A) None None None	1.28A	2mjiA-2dpmA: 0.0	2mjiA-2dpmA: 18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_B_SAMB201_1 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	4 / 5	ALA A 48 ASP A 62 ASP A 177 ASP A 194	SAM A 300 (-3.5A) SAM A 300 (-2.8A) SAM A 300 (-4.1A) SAM A 300 (-3.7A)	1.04A	2nyuB-2dpmA: undetectable	2nyuB-2dpmA: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_D_KLND1499_1 (CYTOCHROME P450 3A4)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	4 / 5	PHE A 214 PHE A 226 PHE A 43 ILE A 255	SAM A 300 ( 4.8A) None SAM A 300 (-4.2A) None	1.34A	2v0mD-2dpmA: undetectable	2v0mD-2dpmA: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCJ_A_THHA401_0 (PROBABLE 5'-PHOSPHORIBOSYLGLY CINAMIDE FORMYLTRANSFERASE PURN)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	MET A 237 LEU A 229 PRO A 55 VAL A 185 PRO A 33	None	1.17A	3dcjA-2dpmA: 2.1 3dcjB-2dpmA: 2.5	3dcjA-2dpmA: 21.75 3dcjB-2dpmA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL5_B_1UNB201_2 (PROTEASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	GLY A 233 ALA A 234 ASP A 189 VAL A 191 VAL A 236	None	0.85A	3el5B-2dpmA: undetectable	3el5B-2dpmA: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1503_0 (FERROCHELATASE, MITOCHONDRIAL)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	4 / 8	ILE A 166 LEU A 171 VAL A 44 GLY A 47	None None None SAM A 300 (-4.5A)	0.83A	3w1wA-2dpmA: 2.6	3w1wA-2dpmA: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM4_B_8PRB603_2 (TRANSPORTER)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	3 / 3	SER A 239 MET A 237 ASP A 62	None None SAM A 300 (-2.8A)	0.88A	4mm4B-2dpmA: undetectable	4mm4B-2dpmA: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTM_A_SAMA301_0 (DNA ADENINE METHYLASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	7 / 12	GLY A 19 GLY A 20 PHE A 43 GLY A 45 ASN A 64 PRO A 196 TYR A 197	SAM A 300 (-4.4A) SAM A 300 (-3.3A) SAM A 300 (-4.2A) SAM A 300 (-3.6A) None SAM A 300 ( 4.1A) None	0.84A	4rtmA-2dpmA: 28.6	4rtmA-2dpmA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTP_A_SAMA301_0 (DNA ADENINE METHYLASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	6 / 12	TRP A 17 PHE A 43 GLY A 45 ASN A 64 ASP A 194 PRO A 196	SAM A 300 (-4.3A) SAM A 300 (-4.2A) SAM A 300 (-3.6A) None SAM A 300 (-3.7A) SAM A 300 ( 4.1A)	0.31A	4rtpA-2dpmA: 9.2	4rtpA-2dpmA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTR_A_SAMA301_0 (DNA ADENINE METHYLASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	8 / 11	TRP A 17 GLY A 19 PHE A 43 ASP A 62 ASN A 64 ASP A 194 PRO A 196 TYR A 197	SAM A 300 (-4.3A) SAM A 300 (-4.4A) SAM A 300 (-4.2A) SAM A 300 (-2.8A) None SAM A 300 (-3.7A) SAM A 300 ( 4.1A) None	0.72A	4rtrA-2dpmA: 28.3	4rtrA-2dpmA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTR_A_SAMA301_0 (DNA ADENINE METHYLASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	7 / 11	TRP A 17 GLY A 20 PHE A 43 ASP A 62 ASN A 64 ASP A 194 PRO A 196	SAM A 300 (-4.3A) SAM A 300 (-3.3A) SAM A 300 (-4.2A) SAM A 300 (-2.8A) None SAM A 300 (-3.7A) SAM A 300 ( 4.1A)	0.97A	4rtrA-2dpmA: 28.3	4rtrA-2dpmA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTS_A_SAMA301_0 (DNA ADENINE METHYLASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	9 / 12	TRP A 17 GLY A 19 PHE A 43 GLY A 45 ASP A 62 ASN A 64 ASP A 194 PRO A 196 TYR A 197	SAM A 300 (-4.3A) SAM A 300 (-4.4A) SAM A 300 (-4.2A) SAM A 300 (-3.6A) SAM A 300 (-2.8A) None SAM A 300 (-3.7A) SAM A 300 ( 4.1A) None	0.74A	4rtsA-2dpmA: 9.6	4rtsA-2dpmA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTS_A_SAMA301_0 (DNA ADENINE METHYLASE)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	7 / 12	TRP A 17 GLY A 20 PHE A 43 GLY A 45 ASP A 62 ASN A 64 ASP A 194	SAM A 300 (-4.3A) SAM A 300 (-3.3A) SAM A 300 (-4.2A) SAM A 300 (-3.6A) SAM A 300 (-2.8A) None SAM A 300 (-3.7A)	1.02A	4rtsA-2dpmA: 9.6	4rtsA-2dpmA: 29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_A_SAMA301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	ASP A 177 ASP A 194 PRO A 196 PHE A 43 GLY A 45	SAM A 300 (-4.1A) SAM A 300 (-3.7A) SAM A 300 ( 4.1A) SAM A 300 (-4.2A) SAM A 300 (-3.6A)	1.21A	5hfjA-2dpmA: 3.2	5hfjA-2dpmA: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_C_SAMC301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	ASP A 177 PRO A 196 LYS A 21 PHE A 43 GLY A 45	SAM A 300 (-4.1A) SAM A 300 ( 4.1A) SAM A 300 (-4.8A) SAM A 300 (-4.2A) SAM A 300 (-3.6A)	1.11A	5hfjC-2dpmA: 3.7	5hfjC-2dpmA: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_F_SAMF301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	ASP A 177 ASP A 194 PRO A 196 PHE A 43 GLY A 45	SAM A 300 (-4.1A) SAM A 300 (-3.7A) SAM A 300 ( 4.1A) SAM A 300 (-4.2A) SAM A 300 (-3.6A)	1.12A	5hfjF-2dpmA: 3.8	5hfjF-2dpmA: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_H_SAMH301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	6 / 12	ASP A 177 ASP A 194 PRO A 196 LYS A 21 PHE A 43 GLY A 45	SAM A 300 (-4.1A) SAM A 300 (-3.7A) SAM A 300 ( 4.1A) SAM A 300 (-4.8A) SAM A 300 (-4.2A) SAM A 300 (-3.6A)	1.21A	5hfjH-2dpmA: 3.9	5hfjH-2dpmA: 22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HGC_A_HCYA501_1 (SERPIN)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	VAL A 115 ALA A 118 ILE A 74 SER A 163 ASN A 77	None	1.30A	5hgcA-2dpmA: undetectable	5hgcA-2dpmA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IL1_A_SAMA601_0 (METTL3)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	ASP A 177 PRO A 196 LYS A 21 GLU A 41 PHE A 43	SAM A 300 (-4.1A) SAM A 300 ( 4.1A) SAM A 300 (-4.8A) None SAM A 300 (-4.2A)	1.22A	5il1A-2dpmA: undetectable	5il1A-2dpmA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5K7U_A_SAMA601_0 (N6-ADENOSINE-METHYLT RANSFERASE 70 KDA SUBUNIT)	2dpm	PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1) (Streptococcus pneumoniae)	5 / 12	ASP A 177 PRO A 196 LYS A 21 GLU A 41 PHE A 43	SAM A 300 (-4.1A) SAM A 300 ( 4.1A) SAM A 300 (-4.8A) None SAM A 300 (-4.2A)	1.21A	5k7uA-2dpmA: undetectable	5k7uA-2dpmA: 19.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DTL_A_BEPA204_1","CARDIAC TROPONIN C","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"ILE A 173;LEU A  81;VAL A  44;LEU A 125;LEU A 122","None","0.94A","1dtlA-2dpmA:undetectable","1dtlA-2dpmA:18.69"],["1K6C_B_MK1B902_2","POL POLYPROTEIN","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"GLY A 233;ALA A 234;ASP A 189;VAL A 191;VAL A 236","None","0.92A","1k6cB-2dpmA:undetectable","1k6cB-2dpmA:18.02"],["1MUI_B_AB1B100_2","PROTEASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"GLY A  47;ASP A  62;ILE A  68;ILE A  74;ILE A  60","SAM A 300 (-4.5A);SAM A 300 (-2.8A);None;None;None","0.89A","1muiB-2dpmA:undetectable","1muiB-2dpmA:17.31"],["1NW5_A_SAMA401_0","MODIFICATION METHYLASE RSRI","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"ASP A 177;PRO A 196;LYS A  21;PHE A  43;GLY A  45","SAM A 300 (-4.1A);SAM A 300 ( 4.1A);SAM A 300 (-4.8A);SAM A 300 (-4.2A);SAM A 300 (-3.6A)","1.08A","1nw5A-2dpmA:3.2","1nw5A-2dpmA:21.94"],["1SQF_A_SAMA430_1","SUN PROTEIN","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"PRO A  42;ASP A  62;ASP A 177","None;SAM A 300 (-2.8A);SAM A 300 (-4.1A)","0.77A","1sqfA-2dpmA:8.1","1sqfA-2dpmA:20.00"],["1T7J_A_478A200_1","POL POLYPROTEIN","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"GLY A 233;ALA A 234;ASP A 189;VAL A 191;VAL A 236","None","0.87A","1t7jA-2dpmA:undetectable","1t7jA-2dpmA:18.02"],["2A3A_A_TEPA1436_1","CHITINASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"ASP A 218;PHE A 178;ARG A 221","None","0.90A","2a3aA-2dpmA:undetectable","2a3aA-2dpmA:20.59"],["2DPM_A_SAMA300_0","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",8,"GLY A  20;LYS A  21;GLY A  45;GLY A  46;ALA A  48;ASP A 177;PHE A 178;PRO A 195","SAM A 300 (-3.3A);SAM A 300 (-4.8A);SAM A 300 (-3.6A);SAM A 300 (-3.3A);SAM A 300 (-3.5A);SAM A 300 (-4.1A);None;None","1.45A","2dpmA-2dpmA:43.8","2dpmA-2dpmA:100.00"],["2DPM_A_SAMA300_0","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",9,"GLY A  20;LYS A  21;PHE A  43;GLY A  45;GLY A  47;PHE A  63;ASP A 177;PHE A 178;PRO A 196","SAM A 300 (-3.3A);SAM A 300 (-4.8A);SAM A 300 (-4.2A);SAM A 300 (-3.6A);SAM A 300 (-4.5A);None;SAM A 300 (-4.1A);None;SAM A 300 ( 4.1A)","0.93A","2dpmA-2dpmA:43.8","2dpmA-2dpmA:100.00"],["2DPM_A_SAMA300_0","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",8,"TRP A  17;GLY A  19;PHE A  43;GLY A  45;PHE A  63;ASN A  64;ASP A 177;PHE A 178","SAM A 300 (-4.3A);SAM A 300 (-4.4A);SAM A 300 (-4.2A);SAM A 300 (-3.6A);None;None;SAM A 300 (-4.1A);None","0.89A","2dpmA-2dpmA:43.8","2dpmA-2dpmA:100.00"],["2DPM_A_SAMA300_0","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",12,"TRP A  17;GLY A  20;LYS A  21;PHE A  43;GLY A  45;GLY A  46;ALA A  48;PHE A  63;ASN A  64;ASP A 177;PHE A 178;PRO A 196","SAM A 300 (-4.3A);SAM A 300 (-3.3A);SAM A 300 (-4.8A);SAM A 300 (-4.2A);SAM A 300 (-3.6A);SAM A 300 (-3.3A);SAM A 300 (-3.5A);None;None;SAM A 300 (-4.1A);None;SAM A 300 ( 4.1A)","0.03A","2dpmA-2dpmA:43.8","2dpmA-2dpmA:100.00"],["2GVC_B_MMZB501_1","MONOOXYGENASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"ASN A 240;TYR A 209;SER A 243","None","0.74A","2gvcB-2dpmA:undetectable","2gvcB-2dpmA:21.63"],["2GVC_E_MMZE501_1","MONOOXYGENASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"ASN A 240;TYR A 209;SER A 243","None","0.68A","2gvcE-2dpmA:undetectable","2gvcE-2dpmA:21.63"],["2IGT_A_SAMA1001_1","SAM DEPENDENT METHYLTRANSFERASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"ASP A  62;ASP A 177;ASP A 194","SAM A 300 (-2.8A);SAM A 300 (-4.1A);SAM A 300 (-3.7A)","0.27A","2igtA-2dpmA:10.1","2igtA-2dpmA:23.42"],["2IGT_B_SAMB1002_1","SAM DEPENDENT METHYLTRANSFERASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"ASP A  62;ASP A 177;ASP A 194","SAM A 300 (-2.8A);SAM A 300 (-4.1A);SAM A 300 (-3.7A)","0.30A","2igtB-2dpmA:10.0","2igtB-2dpmA:23.42"],["2M2P_B_DHIB24_0","INSULIN B CHAIN","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"TYR A  36;GLY A 188;PHE A 190","None","0.43A","2m2pB-2dpmA:undetectable","2m2pB-2dpmA:10.00"],["2MJI_A_KTRA201_1","FATTY ACID-BINDING PROTEIN, INTESTINAL","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"TYR A 192;LYS A  21;GLU A 276;TYR A 197;LEU A 222","None;SAM A 300 (-4.8A);None;None;None","1.28A","2mjiA-2dpmA:0.0","2mjiA-2dpmA:18.93"],["2NYU_B_SAMB201_1","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",4,"ALA A  48;ASP A  62;ASP A 177;ASP A 194","SAM A 300 (-3.5A);SAM A 300 (-2.8A);SAM A 300 (-4.1A);SAM A 300 (-3.7A)","1.04A","2nyuB-2dpmA:undetectable","2nyuB-2dpmA:20.77"],["2V0M_D_KLND1499_1","CYTOCHROME P450 3A4","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",4,"PHE A 214;PHE A 226;PHE A  43;ILE A 255","SAM A 300 ( 4.8A);None;SAM A 300 (-4.2A);None","1.34A","2v0mD-2dpmA:undetectable","2v0mD-2dpmA:17.79"],["3DCJ_A_THHA401_0","PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"MET A 237;LEU A 229;PRO A  55;VAL A 185;PRO A  33","None","1.17A","3dcjA-2dpmA:2.1;3dcjB-2dpmA:2.5","3dcjA-2dpmA:21.75;3dcjB-2dpmA:21.75"],["3EL5_B_1UNB201_2","PROTEASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"GLY A 233;ALA A 234;ASP A 189;VAL A 191;VAL A 236","None","0.85A","3el5B-2dpmA:undetectable","3el5B-2dpmA:18.02"],["3W1W_A_CHDA1503_0","FERROCHELATASE, MITOCHONDRIAL","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",4,"ILE A 166;LEU A 171;VAL A  44;GLY A  47","None;None;None;SAM A 300 (-4.5A)","0.83A","3w1wA-2dpmA:2.6","3w1wA-2dpmA:21.16"],["4MM4_B_8PRB603_2","TRANSPORTER","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",3,"SER A 239;MET A 237;ASP A  62","None;None;SAM A 300 (-2.8A)","0.88A","4mm4B-2dpmA:undetectable","4mm4B-2dpmA:20.27"],["4RTM_A_SAMA301_0","DNA ADENINE METHYLASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",7,"GLY A  19;GLY A  20;PHE A  43;GLY A  45;ASN A  64;PRO A 196;TYR A 197","SAM A 300 (-4.4A);SAM A 300 (-3.3A);SAM A 300 (-4.2A);SAM A 300 (-3.6A);None;SAM A 300 ( 4.1A);None","0.84A","4rtmA-2dpmA:28.6","4rtmA-2dpmA:29.97"],["4RTP_A_SAMA301_0","DNA ADENINE METHYLASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",6,"TRP A  17;PHE A  43;GLY A  45;ASN A  64;ASP A 194;PRO A 196","SAM A 300 (-4.3A);SAM A 300 (-4.2A);SAM A 300 (-3.6A);None;SAM A 300 (-3.7A);SAM A 300 ( 4.1A)","0.31A","4rtpA-2dpmA:9.2","4rtpA-2dpmA:29.97"],["4RTR_A_SAMA301_0","DNA ADENINE METHYLASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",8,"TRP A  17;GLY A  19;PHE A  43;ASP A  62;ASN A  64;ASP A 194;PRO A 196;TYR A 197","SAM A 300 (-4.3A);SAM A 300 (-4.4A);SAM A 300 (-4.2A);SAM A 300 (-2.8A);None;SAM A 300 (-3.7A);SAM A 300 ( 4.1A);None","0.72A","4rtrA-2dpmA:28.3","4rtrA-2dpmA:29.97"],["4RTR_A_SAMA301_0","DNA ADENINE METHYLASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",7,"TRP A  17;GLY A  20;PHE A  43;ASP A  62;ASN A  64;ASP A 194;PRO A 196","SAM A 300 (-4.3A);SAM A 300 (-3.3A);SAM A 300 (-4.2A);SAM A 300 (-2.8A);None;SAM A 300 (-3.7A);SAM A 300 ( 4.1A)","0.97A","4rtrA-2dpmA:28.3","4rtrA-2dpmA:29.97"],["4RTS_A_SAMA301_0","DNA ADENINE METHYLASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",9,"TRP A  17;GLY A  19;PHE A  43;GLY A  45;ASP A  62;ASN A  64;ASP A 194;PRO A 196;TYR A 197","SAM A 300 (-4.3A);SAM A 300 (-4.4A);SAM A 300 (-4.2A);SAM A 300 (-3.6A);SAM A 300 (-2.8A);None;SAM A 300 (-3.7A);SAM A 300 ( 4.1A);None","0.74A","4rtsA-2dpmA:9.6","4rtsA-2dpmA:29.97"],["4RTS_A_SAMA301_0","DNA ADENINE METHYLASE","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",7,"TRP A  17;GLY A  20;PHE A  43;GLY A  45;ASP A  62;ASN A  64;ASP A 194","SAM A 300 (-4.3A);SAM A 300 (-3.3A);SAM A 300 (-4.2A);SAM A 300 (-3.6A);SAM A 300 (-2.8A);None;SAM A 300 (-3.7A)","1.02A","4rtsA-2dpmA:9.6","4rtsA-2dpmA:29.97"],["5HFJ_A_SAMA301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"ASP A 177;ASP A 194;PRO A 196;PHE A  43;GLY A  45","SAM A 300 (-4.1A);SAM A 300 (-3.7A);SAM A 300 ( 4.1A);SAM A 300 (-4.2A);SAM A 300 (-3.6A)","1.21A","5hfjA-2dpmA:3.2","5hfjA-2dpmA:22.71"],["5HFJ_C_SAMC301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"ASP A 177;PRO A 196;LYS A  21;PHE A  43;GLY A  45","SAM A 300 (-4.1A);SAM A 300 ( 4.1A);SAM A 300 (-4.8A);SAM A 300 (-4.2A);SAM A 300 (-3.6A)","1.11A","5hfjC-2dpmA:3.7","5hfjC-2dpmA:22.71"],["5HFJ_F_SAMF301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"ASP A 177;ASP A 194;PRO A 196;PHE A  43;GLY A  45","SAM A 300 (-4.1A);SAM A 300 (-3.7A);SAM A 300 ( 4.1A);SAM A 300 (-4.2A);SAM A 300 (-3.6A)","1.12A","5hfjF-2dpmA:3.8","5hfjF-2dpmA:22.71"],["5HFJ_H_SAMH301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",6,"ASP A 177;ASP A 194;PRO A 196;LYS A  21;PHE A  43;GLY A  45","SAM A 300 (-4.1A);SAM A 300 (-3.7A);SAM A 300 ( 4.1A);SAM A 300 (-4.8A);SAM A 300 (-4.2A);SAM A 300 (-3.6A)","1.21A","5hfjH-2dpmA:3.9","5hfjH-2dpmA:22.71"],["5HGC_A_HCYA501_1","SERPIN","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"VAL A 115;ALA A 118;ILE A  74;SER A 163;ASN A  77","None","1.30A","5hgcA-2dpmA:undetectable","5hgcA-2dpmA:20.82"],["5IL1_A_SAMA601_0","METTL3","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"ASP A 177;PRO A 196;LYS A  21;GLU A  41;PHE A  43","SAM A 300 (-4.1A);SAM A 300 ( 4.1A);SAM A 300 (-4.8A);None;SAM A 300 (-4.2A)","1.22A","5il1A-2dpmA:undetectable","5il1A-2dpmA:19.32"],["5K7U_A_SAMA601_0","N6-ADENOSINE-METHYLTRANSFERASE 70 KDA SUBUNIT","2dpm","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","Streptococcus pneumoniae",5,"ASP A 177;PRO A 196;LYS A  21;GLU A  41;PHE A  43","SAM A 300 (-4.1A);SAM A 300 ( 4.1A);SAM A 300 (-4.8A);None;SAM A 300 (-4.2A)","1.21A","5k7uA-2dpmA:undetectable","5k7uA-2dpmA:19.93"]]