SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 SER A 302
GLY A 301
LEU A 283
GLY A 348
PHE A 134
 None
 1.05A 1fduA-2dpnA:
undetectable		 1fduA-2dpnA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.74A 1fm6A-2dpnA:
undetectable		 1fm6A-2dpnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.84A 1fm6U-2dpnA:
undetectable		 1fm6U-2dpnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.99A 1fm9A-2dpnA:
undetectable		 1fm9A-2dpnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.94A 1k74A-2dpnA:
undetectable		 1k74A-2dpnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 7 LEU A   5
ILE A  50
THR A  54
GLN A  80
 None
 1.16A 1kglA-2dpnA:
undetectable		 1kglA-2dpnA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 LEU A 450
SER A 451
PRO A 452
GLY A 448
GLY A 446
GLY A 444
 None
 1.00A 1uakA-2dpnA:
undetectable		 1uakA-2dpnA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 8 PHE A 267
THR A  11
THR A 345
VAL A 305
 None
 0.91A 1uyuA-2dpnA:
undetectable		 1uyuA-2dpnA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A 436
GLY A 438
LEU A 437
VAL A 428
PRO A 429
 None
 1.23A 1vpoH-2dpnA:
undetectable
1vpoL-2dpnA:
undetectable		 1vpoH-2dpnA:
17.78
1vpoL-2dpnA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.82A 1xiuA-2dpnA:
undetectable		 1xiuA-2dpnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.98A 1xiuB-2dpnA:
undetectable		 1xiuB-2dpnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.90A 1xlsA-2dpnA:
undetectable		 1xlsA-2dpnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.91A 1xlsB-2dpnA:
undetectable		 1xlsB-2dpnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.91A 1xlsC-2dpnA:
undetectable		 1xlsC-2dpnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.90A 1xlsD-2dpnA:
undetectable		 1xlsD-2dpnA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.18A 1ya3A-2dpnA:
undetectable		 1ya3A-2dpnA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.28A 2aa5B-2dpnA:
undetectable		 2aa5B-2dpnA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 6 ASP A 242
PHE A 267
GLU A  82
GLU A 300
 None
 1.49A 2dttB-2dpnA:
undetectable
2dttC-2dpnA:
undetectable		 2dttB-2dpnA:
11.31
2dttC-2dpnA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 ASN A 191
TYR A 297
SER A 185
 None
 0.94A 2gvcB-2dpnA:
undetectable		 2gvcB-2dpnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 5 ALA A  29
TRP A  56
LEU A  55
ALA A  16
 None
 1.09A 2jstA-2dpnA:
undetectable
2jstB-2dpnA:
undetectable		 2jstA-2dpnA:
11.19
2jstB-2dpnA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.29A 2oaxB-2dpnA:
undetectable		 2oaxB-2dpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.27A 2oaxD-2dpnA:
undetectable		 2oaxD-2dpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.28A 2oaxE-2dpnA:
undetectable		 2oaxE-2dpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 8 MET A 442
GLY A 444
GLY A 220
ASP A 221
 None
 0.58A 2yfxA-2dpnA:
undetectable		 2yfxA-2dpnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 SER A 451
PRO A 452
GLY A 448
GLY A 446
GLY A 444
 None
 0.93A 3axzA-2dpnA:
undetectable		 3axzA-2dpnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
 None
 0.98A 3fc6C-2dpnA:
undetectable		 3fc6C-2dpnA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 7 PHE A 267
THR A  11
THR A 345
VAL A 305
 None
 0.99A 3fwiA-2dpnA:
undetectable		 3fwiA-2dpnA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
LEU A 171
 None
 0.71A 3h0aA-2dpnA:
undetectable		 3h0aA-2dpnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
 None
 0.88A 3h0aA-2dpnA:
undetectable		 3h0aA-2dpnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 ARG A  81
ASP A 164
ASP A 242
 None
 0.90A 3jb2A-2dpnA:
undetectable		 3jb2A-2dpnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 GLY A 444
ALA A 443
VAL A 239
ILE A 236
PRO A 217
 None
 1.00A 3nu5B-2dpnA:
undetectable		 3nu5B-2dpnA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.82A 3oapA-2dpnA:
undetectable		 3oapA-2dpnA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 THR A 261
ASP A 242
GLU A  82
 None
 0.85A 3qowA-2dpnA:
undetectable		 3qowA-2dpnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.39A 3uboB-2dpnA:
undetectable		 3uboB-2dpnA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.79A 3uvvB-2dpnA:
undetectable		 3uvvB-2dpnA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.98A 3uvvB-2dpnA:
undetectable		 3uvvB-2dpnA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 4 ASN A 271
SER A 279
LEU A 283
THR A 296
 None
 1.49A 4an2A-2dpnA:
undetectable		 4an2A-2dpnA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 ARG A 186
THR A  83
TRP A 101
 None
 1.15A 4d7hA-2dpnA:
undetectable		 4d7hA-2dpnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4e3aA-2dpnA:
undetectable		 4e3aA-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4e3aB-2dpnA:
undetectable		 4e3aB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.29A 4fn9B-2dpnA:
undetectable		 4fn9B-2dpnA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.45A 4jkuB-2dpnA:
undetectable		 4jkuB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 8 VAL A 316
TRP A 312
LEU A 363
LEU A 360
 None
 0.96A 4jtrA-2dpnA:
undetectable		 4jtrA-2dpnA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4k8pA-2dpnA:
undetectable		 4k8pA-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4k8pB-2dpnA:
undetectable		 4k8pB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4k8tA-2dpnA:
undetectable		 4k8tA-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4k8tB-2dpnA:
undetectable		 4k8tB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4k93A-2dpnA:
undetectable		 4k93A-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4k93B-2dpnA:
undetectable		 4k93B-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4k9cA-2dpnA:
undetectable		 4k9cA-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4k9cB-2dpnA:
undetectable		 4k9cB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4k9iA-2dpnA:
undetectable		 4k9iA-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4k9iB-2dpnA:
undetectable		 4k9iB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4kadA-2dpnA:
undetectable		 4kadA-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4kadB-2dpnA:
undetectable		 4kadB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 8 ALA A  16
ASP A 164
ILE A  77
ILE A 236
 None
 0.75A 4kttB-2dpnA:
undetectable		 4kttB-2dpnA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 8 ALA A  16
ASP A 164
ILE A  77
ILE A 236
 None
 0.70A 4kttD-2dpnA:
undetectable		 4kttD-2dpnA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4lbxA-2dpnA:
undetectable		 4lbxA-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.43A 4lbxB-2dpnA:
undetectable		 4lbxB-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.44A 4lc4A-2dpnA:
undetectable		 4lc4A-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 241
ASN A  79
THR A 286
LEU A 284
GLU A  82
THR A 179
 None
 1.42A 4lc4B-2dpnA:
undetectable		 4lc4B-2dpnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 9 VAL A 388
LEU A 389
LEU A 268
GLY A 423
LEU A 402
 None
 1.04A 4rs0A-2dpnA:
undetectable		 4rs0A-2dpnA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 ARG A 186
THR A  83
TRP A 101
 None
 1.17A 4ug5A-2dpnA:
undetectable		 4ug5A-2dpnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 ARG A 186
THR A  83
TRP A 101
 None
 1.20A 4uglA-2dpnA:
undetectable		 4uglA-2dpnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A 436
LEU A   7
THR A  53
ALA A  57
VAL A  61
 None
 1.26A 4x1iB-2dpnA:
undetectable		 4x1iB-2dpnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 SER A 451
PRO A 452
GLY A 448
GLY A 446
GLY A 444
 None
 0.92A 4yvgA-2dpnA:
undetectable		 4yvgA-2dpnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 7 LEU A 229
THR A  54
LEU A  55
THR A 225
 None
 0.85A 4z90A-2dpnA:
undetectable
4z90B-2dpnA:
undetectable
4z90C-2dpnA:
undetectable
4z90D-2dpnA:
undetectable
4z90E-2dpnA:
undetectable		 4z90A-2dpnA:
20.83
4z90B-2dpnA:
20.83
4z90C-2dpnA:
20.83
4z90D-2dpnA:
20.83
4z90E-2dpnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 10 ALA A 288
LEU A 299
LEU A 247
LEU A 253
ALA A 252
 None
 1.20A 4zbrA-2dpnA:
undetectable		 4zbrA-2dpnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 10 ASN A 170
LEU A 167
PRO A  94
GLY A  10
GLN A  80
 None
 1.35A 4zp0A-2dpnA:
0.0		 4zp0A-2dpnA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 GLY A 241
LEU A 247
GLY A 238
ILE A  77
GLY A 249
 None
 0.96A 5d4uC-2dpnA:
undetectable		 5d4uC-2dpnA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 GLY A 241
LEU A 247
GLY A 238
ILE A  77
GLY A 249
 None
 0.95A 5d4uD-2dpnA:
undetectable		 5d4uD-2dpnA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 ARG A 186
THR A  83
TRP A 101
 None
 1.14A 5g6cA-2dpnA:
undetectable		 5g6cA-2dpnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 8 HIS A  96
LEU A 149
LEU A 142
THR A 106
 None
 1.10A 5hs6A-2dpnA:
undetectable		 5hs6A-2dpnA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 5 TYR A 351
VAL A 485
PRO A 342
ALA A 488
 None
 1.09A 5otrA-2dpnA:
undetectable		 5otrA-2dpnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.73A 5uanA-2dpnA:
undetectable		 5uanA-2dpnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 8 SER A 322
ARG A 369
VAL A 310
GLU A 321
 None
 1.05A 5uo7A-2dpnA:
undetectable
5uo7B-2dpnA:
undetectable		 5uo7A-2dpnA:
20.67
5uo7B-2dpnA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 7 LEU A 313
ARG A 357
THR A 359
LEU A 360
 None
 0.96A 5xdqA-2dpnA:
undetectable
5xdqJ-2dpnA:
undetectable		 5xdqA-2dpnA:
22.49
5xdqJ-2dpnA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		6 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 1.04A 5z12B-2dpnA:
undetectable		 5z12B-2dpnA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.83A 5z12C-2dpnA:
undetectable		 5z12C-2dpnA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		5 / 12 ALA A  57
ALA A  58
LEU A   5
ALA A  29
LEU A 171
 None
 0.85A 6a60D-2dpnA:
undetectable		 6a60D-2dpnA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 LEU A 269
THR A  78
ASN A  79
 None
 0.72A 6baaE-2dpnA:
undetectable		 6baaE-2dpnA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 LEU A 269
THR A  78
ASN A  79
 None
 0.72A 6baaF-2dpnA:
undetectable		 6baaF-2dpnA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 LEU A 269
THR A  78
ASN A  79
 None
 0.73A 6baaG-2dpnA:
0.0		 6baaG-2dpnA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		3 / 3 LEU A 269
THR A  78
ASN A  79
 None
 0.73A 6baaH-2dpnA:
undetectable		 6baaH-2dpnA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 6 ARG A  89
ALA A 159
LEU A 211
ALA A 210
 None
 1.08A 6fosB-2dpnA:
undetectable		 6fosB-2dpnA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2dpn GLYCEROL KINASE
(Thermus
thermophilus) 		4 / 6 THR A 286
LEU A 284
THR A 272
LEU A 268
 None
 1.23A 6mvxA-2dpnA:
undetectable
6mvxB-2dpnA:
undetectable
6mvxC-2dpnA:
undetectable		 6mvxA-2dpnA:
18.71
6mvxB-2dpnA:
18.71
6mvxC-2dpnA:
18.71