SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 12 LEU A 127
ILE A 173
PRO A 179
VAL A 197
VAL A 104
 None
 1.41A 1hrkB-2dppA:
undetectable		 1hrkB-2dppA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 11 ARG B 188
GLY B  58
GLU B  54
MET B  49
ILE B  59
 None
 1.25A 1odiC-2dppB:
undetectable		 1odiC-2dppB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 6 SER A 169
ARG A 174
LEU A 127
PHE A 175
 CSO  A 121 ( 4.0A)
CSO  A 121 ( 3.3A)
None
None
 1.23A 2f8dA-2dppA:
undetectable		 2f8dA-2dppA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 7 ILE B 148
GLY B 170
LEU B 206
PHE B 161
 None
 1.03A 2vctD-2dppB:
undetectable		 2vctD-2dppB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 7 SER A 170
VAL A 144
TYR B 164
ILE B 217
 None
 1.24A 2x45C-2dppA:
undetectable		 2x45C-2dppA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 6 ASP A 168
ASP B 218
LEU B 196
HIS B 179
 None
 1.24A 3bj8C-2dppA:
undetectable
3bj8D-2dppA:
undetectable		 3bj8C-2dppA:
24.35
3bj8D-2dppA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 7 SER A 170
VAL A 144
TYR B 164
ILE B 217
 None
 1.17A 3bu1A-2dppA:
undetectable		 3bu1A-2dppA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8;
Bacillus
sp.
RAPc8) 		4 / 8 TYR B  26
ASP B  30
GLU A  33
GLU A  48
 None
 1.30A 3dh0A-2dppB:
undetectable		 3dh0A-2dppB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8;
Bacillus
sp.
RAPc8) 		4 / 5 TYR B  26
ASP B  30
GLU A  33
GLU A  48
 None
 1.32A 3dh0B-2dppB:
0.0		 3dh0B-2dppB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 8 SER A 171
TYR B 176
VAL A 103
LEU A  88
 None
 0.96A 3jq7C-2dppA:
undetectable		 3jq7C-2dppA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 9 TYR B  72
TYR B  73
PHE B  27
GLY B  37
ALA B  40
 None
 0.96A 3jusB-2dppB:
undetectable		 3jusB-2dppB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		3 / 3 ARG B 166
VAL A 144
THR A 117
 None
 0.82A 3ndtA-2dppB:
undetectable		 3ndtA-2dppB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 11 ARG B 160
ALA B 165
VAL B 215
GLY B   9
ILE B 217
 CSO  A 121 ( 3.6A)
None
None
None
None
 0.98A 3oxvD-2dppB:
undetectable		 3oxvD-2dppB:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 8 VAL A 177
HIS A 111
PRO A 131
TRP A 133
 None
 1.42A 3v35A-2dppA:
undetectable		 3v35A-2dppA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 12 LEU A 127
ILE A 173
PRO A 179
VAL A 197
VAL A 104
 None
 1.33A 3w1wA-2dppA:
undetectable		 3w1wA-2dppA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 12 LEU A 127
ILE A 173
PRO A 179
VAL A 197
VAL A 104
 None
 1.32A 3w1wB-2dppA:
undetectable		 3w1wB-2dppA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 10 ARG B 160
ALA B 165
VAL B 215
GLY B   9
ILE B 217
 CSO  A 121 ( 3.6A)
None
None
None
None
 1.00A 4dqcA-2dppB:
undetectable		 4dqcA-2dppB:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 11 ARG B 160
ALA B 165
VAL B 215
GLY B   9
ILE B 217
 CSO  A 121 ( 3.6A)
None
None
None
None
 0.97A 4dqeA-2dppB:
undetectable		 4dqeA-2dppB:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8;
Bacillus
sp.
RAPc8) 		4 / 6 ASP B 218
SER A 170
ARG A 174
GLU A 172
 None
None
CSO  A 121 ( 3.3A)
None
 1.13A 4eysA-2dppB:
undetectable		 4eysA-2dppB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 5 GLY A 128
GLY A  59
MET A  61
ASN A  62
 None
 1.08A 4fglC-2dppA:
undetectable		 4fglC-2dppA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 9 TYR B  72
PHE B  36
PHE B  55
ILE B  77
 None
 1.12A 4jvlA-2dppB:
undetectable		 4jvlA-2dppB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 8 ALA B 165
VAL B 215
GLY B   8
ILE B 217
 None
 0.64A 4ll3A-2dppB:
undetectable		 4ll3A-2dppB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 9 ARG B 160
ALA B 165
VAL B 215
GLY B   9
ILE B 217
 CSO  A 121 ( 3.6A)
None
None
None
None
 1.08A 4ll3B-2dppB:
undetectable		 4ll3B-2dppB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 5 ILE A  47
ARG B 113
GLU A  33
VAL B  80
 None
 1.22A 4nkxC-2dppA:
undetectable		 4nkxC-2dppA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 5 ILE A  47
ARG B 113
GLU A  33
VAL B  80
 None
 1.25A 4nkxD-2dppA:
undetectable		 4nkxD-2dppA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 8 LYS A  30
ALA A  31
LEU A  35
LEU B  95
 None
 0.86A 4po0A-2dppA:
undetectable		 4po0A-2dppA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		5 / 10 ARG B 160
ALA B 165
VAL B 215
GLY B   9
ILE B 217
 CSO  A 121 ( 3.6A)
None
None
None
None
 1.03A 4q1wB-2dppB:
undetectable		 4q1wB-2dppB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8;
Bacillus
sp.
RAPc8) 		4 / 6 HIS B 158
ASP B   6
LEU A 118
HIS B   5
 None
 1.04A 5nelB-2dppB:
undetectable
5nelC-2dppB:
undetectable		 5nelB-2dppB:
24.56
5nelC-2dppB:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 6 TYR B 197
VAL B 199
ILE B 148
GLU B 146
 None
 0.93A 5z3jA-2dppB:
undetectable		 5z3jA-2dppB:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8;
Bacillus
sp.
RAPc8) 		5 / 12 TYR A  94
SER A 120
PHE B  52
PHE B  55
LEU B 130
 None
CSO  A 121 (-3.7A)
None
None
None
 1.10A 6a93B-2dppA:
undetectable		 6a93B-2dppA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
(Bacillus
sp.
RAPc8) 		3 / 3 TYR A 134
PRO A 123
LEU A 127
 CSO  A 121 ( 4.5A)
None
None
 0.88A 6beoA-2dppA:
undetectable		 6beoA-2dppA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2dpp NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8) 		4 / 8 ILE B   4
ALA B  78
THR B  79
TYR B  82
 None
 0.91A 6cduD-2dppB:
undetectable
6cduE-2dppB:
undetectable		 6cduD-2dppB:
20.85
6cduE-2dppB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2dpp NITRILE HYDRATASE
ALPHA SUBUNIT
NITRILE HYDRATASE
BETA SUBUNIT
(Bacillus
sp.
RAPc8;
Bacillus
sp.
RAPc8) 		4 / 8 ARG A 140
VAL A 104
ARG A 148
GLN B 211
 None
 1.26A 6fbvD-2dppA:
undetectable		 6fbvD-2dppA:
9.92