SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		4 / 7 SER A 154
ASP A 152
SER A   4
LEU A  80
 None
 1.01A 2cdqB-2dpwA:
undetectable		 2cdqB-2dpwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		3 / 3 ARG A 226
VAL A 222
THR A 131
 None
 0.81A 2nnkA-2dpwA:
undetectable		 2nnkA-2dpwA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		5 / 12 LEU A  42
LEU A  88
LEU A 213
PRO A 117
VAL A 115
 None
 1.38A 2qd4A-2dpwA:
2.2		 2qd4A-2dpwA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		5 / 8 ALA A 101
GLU A 219
LEU A  42
ILE A  94
VAL A   7
 None
 1.46A 2uxpA-2dpwA:
undetectable		 2uxpA-2dpwA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		5 / 12 LEU A  47
VAL A 105
VAL A 102
LEU A  97
ILE A  94
 None
 1.09A 3gwxB-2dpwA:
undetectable		 3gwxB-2dpwA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		6 / 12 LEU A  58
GLY A  10
ALA A   9
ASP A  93
ILE A  94
ILE A   6
 None
 1.41A 3k4vA-2dpwA:
undetectable		 3k4vA-2dpwA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		6 / 12 LEU A  58
GLY A  10
ALA A   9
ASP A  93
ILE A  94
ILE A   6
 None
 1.45A 3k4vB-2dpwA:
undetectable		 3k4vB-2dpwA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		3 / 3 ARG A 226
VAL A 222
THR A 131
 None
 0.87A 3nduD-2dpwA:
undetectable		 3nduD-2dpwA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		3 / 3 ARG A 226
VAL A 222
THR A 131
 None
 0.78A 3pwrA-2dpwA:
undetectable		 3pwrA-2dpwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		3 / 3 ARG A 226
VAL A 222
THR A 131
 None
 0.81A 3tl9A-2dpwA:
undetectable		 3tl9A-2dpwA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		4 / 5 GLY A  11
GLY A  10
ASN A  75
GLU A  13
 None
 1.31A 4fglC-2dpwA:
undetectable		 4fglC-2dpwA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		5 / 12 LEU A 148
VAL A 102
ALA A  90
LEU A 151
LEU A 150
 None
 1.15A 4i1rA-2dpwA:
undetectable		 4i1rA-2dpwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		5 / 12 LEU A  97
ALA A  41
ALA A   5
VAL A   7
ALA A  90
 None
 1.08A 4x1iB-2dpwA:
undetectable		 4x1iB-2dpwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		5 / 12 LEU A  97
ALA A  41
ALA A   5
VAL A   7
ALA A  90
 None
 1.02A 4x20B-2dpwA:
undetectable		 4x20B-2dpwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2dpw HYPOTHETICAL PROTEIN
TTHA0179
(Thermus
thermophilus) 		5 / 12 LEU A  66
VAL A  52
LEU A   8
VAL A  83
LEU A  47
 None
 1.00A 4y0qA-2dpwA:
undetectable		 4y0qA-2dpwA:
22.27