SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 HIS A 380
GLU A 357
ALA A 331
SER A 354
 None
 1.38A 1errA-2dq3A:
undetectable
1errB-2dq3A:
undetectable		 1errA-2dq3A:
20.51
1errB-2dq3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 11 LEU A 299
TYR A 296
GLU A 307
VAL A 303
LEU A 327
 None
 1.17A 1mrqA-2dq3A:
undetectable		 1mrqA-2dq3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A  91
VAL A  94
LEU A  98
 None
 0.45A 1mz9B-2dq3A:
undetectable		 1mz9B-2dq3A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 ASP A 224
GLU A 222
LEU A 228
LEU A 226
 None
 1.06A 1np1A-2dq3A:
undetectable		 1np1A-2dq3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LEU A 382
GLY A 190
PRO A 251
VAL A 290
 None
 0.91A 2aojA-2dq3A:
undetectable		 2aojA-2dq3A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ILE A 167
LEU A 397
ALA A 395
ILE A 396
ILE A 179
 None
 1.03A 3b2rA-2dq3A:
2.8		 3b2rA-2dq3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 11 ILE A 167
LEU A 397
ALA A 395
ILE A 396
ILE A 179
 None
 1.07A 3b2rB-2dq3A:
undetectable		 3b2rB-2dq3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 ALA A 395
ILE A 396
ASN A 399
PRO A 410
 None
 0.51A 3fxrA-2dq3A:
undetectable		 3fxrA-2dq3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 LEU A  49
LEU A  46
ARG A  38
 None
 0.63A 3hcnB-2dq3A:
undetectable		 3hcnB-2dq3A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 SER A 343
PHE A 341
LYS A 346
 None
 0.84A 3u88A-2dq3A:
undetectable		 3u88A-2dq3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 GLN A 402
ARG A 132
VAL A 408
VAL A 421
 None
 0.99A 3uy4A-2dq3A:
undetectable		 3uy4A-2dq3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LYS A 301
LEU A 302
GLU A 298
LEU A 382
 None
 1.29A 4k4yA-2dq3A:
undetectable		 4k4yA-2dq3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 4 LYS A 301
LEU A 302
GLU A 298
LEU A 382
 None
 1.31A 4k4yE-2dq3A:
undetectable		 4k4yE-2dq3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LYS A 301
LEU A 302
GLU A 298
LEU A 382
 None
 1.32A 4k4yI-2dq3A:
undetectable		 4k4yI-2dq3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 ARG A 262
ASP A 336
GLU A 119
ARG A 391
 SSA  A1001 (-2.8A)
None
None
SSA  A1001 (-3.3A)
 1.41A 4kr4C-2dq3A:
undetectable		 4kr4C-2dq3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.02A 4q15B-2dq3A:
22.8		 4q15B-2dq3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.00A 4ydqA-2dq3A:
22.6		 4ydqA-2dq3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.04A 4ydqB-2dq3A:
22.3		 4ydqB-2dq3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.04A 5f9zB-2dq3A:
22.4		 5f9zB-2dq3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ILE A 276
ASP A 336
VAL A 339
ALA A 306
GLY A 384
 None
None
None
None
SSA  A1001 (-3.7A)
 1.07A 5igjA-2dq3A:
0.1		 5igjA-2dq3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ILE A 167
GLY A 390
GLU A 425
ALA A 177
ILE A 144
 None
 1.23A 5igyA-2dq3A:
undetectable		 5igyA-2dq3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 GLU A 298
HIS A 291
VAL A 290
 None
 0.90A 5trqB-2dq3A:
undetectable		 5trqB-2dq3A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 GLU A 264
ARG A 262
GLU A 233
SER A 354
GLY A 384
 SSA  A1001 (-3.3A)
SSA  A1001 (-2.8A)
SSA  A1001 (-3.7A)
None
SSA  A1001 (-3.7A)
 1.12A 5xioA-2dq3A:
11.6		 5xioA-2dq3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 LEU A 205
PRO A 230
THR A 231
GLU A 233
ARG A 262
 None
None
SSA  A1001 (-3.2A)
SSA  A1001 (-3.7A)
SSA  A1001 (-2.8A)
 1.05A 5xipD-2dq3A:
22.0		 5xipD-2dq3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 10 ARG A 262
GLU A 264
PHE A 281
GLU A 349
ARG A 391
 SSA  A1001 (-2.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.5A)
SSA  A1001 (-3.1A)
SSA  A1001 (-3.3A)
 0.68A 6bniA-2dq3A:
4.9		 6bniA-2dq3A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 10 ARG A 262
GLU A 264
PHE A 281
GLU A 349
ARG A 391
 SSA  A1001 (-2.8A)
SSA  A1001 (-3.3A)
SSA  A1001 (-3.5A)
SSA  A1001 (-3.1A)
SSA  A1001 (-3.3A)
 0.66A 6bniB-2dq3A:
12.4		 6bniB-2dq3A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2dq3 SERYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ARG A 173
ILE A 179
LEU A 178
GLY A 390
ALA A 172
 None
 1.14A 6c2mA-2dq3A:
undetectable		 6c2mA-2dq3A:
11.27