SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		5 / 12 ILE A 256
PHE A 255
GLY A 253
LEU A 299
LEU A 228
 None
 1.35A 1fm6X-2dqbA:
undetectable		 1fm6X-2dqbA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 8 ALA A  23
LEU A 100
ALA A 275
THR A 186
 None
 0.90A 1ie4B-2dqbA:
undetectable
1ie4D-2dqbA:
undetectable		 1ie4B-2dqbA:
15.71
1ie4D-2dqbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		3 / 3 PHE A 255
LEU A 224
LEU A 228
 None
 0.62A 1mx1E-2dqbA:
0.9		 1mx1E-2dqbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 THR A 186
ARG A 279
THR A  40
ASP A  47
 None
 1.11A 2okcB-2dqbA:
undetectable		 2okcB-2dqbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 8 HIS A 108
ASP A 109
ARG A  74
ALA A 199
 MG  A 506 (-4.6A)
MG  A 506 (-2.9A)
None
None
 1.18A 2rk8A-2dqbA:
undetectable		 2rk8A-2dqbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 4 GLU A 134
ASP A 109
HIS A 112
GLU A 120
 None
MG  A 506 (-2.9A)
None
None
 1.42A 2x45A-2dqbA:
undetectable		 2x45A-2dqbA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 5 HIS A 112
HIS A 117
ASP A 109
ASP A 196
 None
None
MG  A 506 (-2.9A)
MG  A 506 (-2.4A)
 1.09A 3c0zA-2dqbA:
undetectable		 3c0zA-2dqbA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 HIS A 112
HIS A 117
ASP A 109
ASP A 196
 None
None
MG  A 506 (-2.9A)
MG  A 506 (-2.4A)
 1.09A 3c0zC-2dqbA:
undetectable		 3c0zC-2dqbA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		5 / 12 LEU A 327
ALA A 330
LEU A 338
LEU A 337
MET A 362
 None
 1.13A 3erdA-2dqbA:
undetectable		 3erdA-2dqbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 HIS A 112
HIS A 135
HIS A 117
ASP A 196
 None
None
None
MG  A 506 (-2.4A)
 1.09A 3nvcA-2dqbA:
undetectable		 3nvcA-2dqbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		3 / 3 GLN A  63
THR A  75
LEU A 106
 MG  A 506 ( 4.5A)
None
None
 0.63A 3ondA-2dqbA:
undetectable		 3ondA-2dqbA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		3 / 3 GLN A  63
THR A  75
LEU A 106
 MG  A 506 ( 4.5A)
None
None
 0.63A 3ondB-2dqbA:
undetectable		 3ondB-2dqbA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 5 ILE A 142
ALA A 360
HIS A 145
ARG A 353
 None
 1.35A 4ac9B-2dqbA:
undetectable
4ac9C-2dqbA:
undetectable		 4ac9B-2dqbA:
20.82
4ac9C-2dqbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZF_B_ACTB502_0
(ALDOSE 1-EPIMERASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 4 HIS A 135
HIS A 117
ASP A 196
TYR A 200
 None
None
MG  A 506 (-2.4A)
MG  A 506 (-4.3A)
 1.43A 4bzfB-2dqbA:
undetectable		 4bzfB-2dqbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		5 / 12 ASP A 109
HIS A 108
ASP A 193
GLU A 134
GLU A 120
 MG  A 506 (-2.9A)
MG  A 506 (-4.6A)
None
None
None
 1.33A 4dfuB-2dqbA:
0.0		 4dfuB-2dqbA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 LEU A  58
HIS A 135
HIS A 117
TYR A 200
 None
None
None
MG  A 506 (-4.3A)
 0.85A 4pahA-2dqbA:
undetectable		 4pahA-2dqbA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 5 LEU A 296
ALA A 258
VAL A  86
ILE A  90
 None
 0.88A 4xe3A-2dqbA:
undetectable		 4xe3A-2dqbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 5 LEU A 296
ALA A 258
VAL A  86
ILE A  90
 None
 0.71A 4xe3B-2dqbA:
undetectable		 4xe3B-2dqbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		5 / 12 LEU A 327
ALA A 330
LEU A 338
LEU A 337
MET A 362
 None
 1.13A 4zn7A-2dqbA:
undetectable		 4zn7A-2dqbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		5 / 11 LEU A 327
ALA A 330
LEU A 338
LEU A 337
MET A 362
 None
 1.18A 4zn7B-2dqbA:
undetectable		 4zn7B-2dqbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		3 / 3 VAL A 191
HIS A 264
VAL A 267
 None
 0.47A 5jmnC-2dqbA:
undetectable		 5jmnC-2dqbA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 7 HIS A 108
LEU A 100
VAL A 192
SER A  87
 MG  A 506 (-4.6A)
None
None
None
 0.99A 5m8rA-2dqbA:
undetectable		 5m8rA-2dqbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 8 HIS A 108
LEU A 100
VAL A 192
SER A  87
 MG  A 506 (-4.6A)
None
None
None
 1.01A 5m8rB-2dqbA:
undetectable		 5m8rB-2dqbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 HIS A 135
HIS A 112
HIS A 108
HIS A  79
 None
None
MG  A 506 (-4.6A)
MG  A 506 (-3.4A)
 0.89A 5ncdA-2dqbA:
undetectable
5ncdD-2dqbA:
undetectable		 5ncdA-2dqbA:
22.02
5ncdD-2dqbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 HIS A  79
HIS A 135
HIS A 112
HIS A 108
 MG  A 506 (-3.4A)
None
None
MG  A 506 (-4.6A)
 0.90A 5ncdB-2dqbA:
undetectable
5ncdC-2dqbA:
undetectable		 5ncdB-2dqbA:
22.02
5ncdC-2dqbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 HIS A 135
HIS A 112
HIS A 108
HIS A  79
 None
None
MG  A 506 (-4.6A)
MG  A 506 (-3.4A)
 0.80A 5nelA-2dqbA:
undetectable
5nelD-2dqbA:
undetectable		 5nelA-2dqbA:
22.02
5nelD-2dqbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 HIS A  79
HIS A 135
HIS A 112
HIS A 108
 MG  A 506 (-3.4A)
None
None
MG  A 506 (-4.6A)
 0.82A 5nelB-2dqbA:
undetectable
5nelC-2dqbA:
undetectable		 5nelB-2dqbA:
22.02
5nelC-2dqbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		5 / 12 ILE A  49
LEU A 158
GLY A 111
ALA A 139
LEU A 140
 None
 1.20A 5zwrA-2dqbA:
undetectable		 5zwrA-2dqbA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE
(Thermus
thermophilus) 		4 / 6 LEU A  58
HIS A 135
HIS A 117
TYR A 200
 None
None
None
MG  A 506 (-4.3A)
 0.91A 6pahA-2dqbA:
undetectable		 6pahA-2dqbA:
21.46