SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		4 / 5 LEU A  37
LEU A  35
SER A 101
LEU A 102
 None
 1.04A 1a4lC-2dqwA:
5.3		 1a4lC-2dqwA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.06A 1dfoA-2dqwA:
undetectable		 1dfoA-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.06A 1dfoB-2dqwA:
undetectable		 1dfoB-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.06A 1dfoC-2dqwA:
undetectable		 1dfoC-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.06A 1dfoD-2dqwA:
undetectable		 1dfoD-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.04A 1eqbA-2dqwA:
undetectable		 1eqbA-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.04A 1eqbB-2dqwA:
undetectable		 1eqbB-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.04A 1eqbC-2dqwA:
undetectable		 1eqbC-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  32
GLY A  33
LEU A 266
VAL A 195
ALA A  66
 None
 1.04A 1eqbD-2dqwA:
undetectable		 1eqbD-2dqwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 PHE A 200
LEU A 216
MET A 261
 None
 0.80A 1mx1D-2dqwA:
undetectable		 1mx1D-2dqwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ASP A 109
ASN A 128
ASP A 197
GLY A 229
SER A 231
 None
 1.00A 1q8jA-2dqwA:
21.7		 1q8jA-2dqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 LEU A  71
LEU A  32
MET A  61
 None
 0.77A 1ya3B-2dqwA:
undetectable		 1ya3B-2dqwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		4 / 7 LEU A  17
LEU A  19
GLU A 283
ARG A  28
 None
 1.06A 2jn3A-2dqwA:
undetectable		 2jn3A-2dqwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		4 / 7 GLY A 103
ASP A  21
VAL A 106
LEU A 100
 None
 0.74A 2oa1B-2dqwA:
undetectable		 2oa1B-2dqwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  19
ASP A  70
VAL A  34
SER A 231
ASN A 128
 None
 1.42A 2y00A-2dqwA:
undetectable		 2y00A-2dqwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 VAL A 147
ASP A  70
VAL A  34
SER A 231
ASN A 128
 None
 1.39A 2y00A-2dqwA:
undetectable		 2y00A-2dqwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ASP A 109
ASN A 128
ASP A 197
GLY A 229
SER A 231
 None
 1.11A 2ycjA-2dqwA:
21.4		 2ycjA-2dqwA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 VAL A  62
ALA A  58
LEU A  71
LEU A 100
ARG A  22
 None
 1.23A 3hj3C-2dqwA:
undetectable		 3hj3C-2dqwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ASP A 109
ASN A 128
VAL A 150
GLY A 229
SER A 231
 None
 0.98A 3k13B-2dqwA:
18.5		 3k13B-2dqwA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 124
LEU A  19
HIS A 145
ALA A 186
LEU A 133
 None
 1.11A 3tm4A-2dqwA:
undetectable		 3tm4A-2dqwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  19
GLY A 146
HIS A 145
ALA A 186
LEU A 133
 None
 1.12A 3tm4A-2dqwA:
undetectable		 3tm4A-2dqwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 124
LEU A  19
HIS A 145
ALA A 186
LEU A 133
 None
 1.09A 3tm4B-2dqwA:
undetectable		 3tm4B-2dqwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  19
GLY A 146
HIS A 145
ALA A 186
LEU A 133
 None
 1.14A 3tm4B-2dqwA:
undetectable		 3tm4B-2dqwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		4 / 7 ASN A 209
LEU A 210
GLY A 237
SER A 240
 None
 1.01A 4cp3A-2dqwA:
undetectable
4cp3B-2dqwA:
undetectable		 4cp3A-2dqwA:
18.90
4cp3B-2dqwA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		6 / 12 ASP A  70
ASP A 109
ASN A 128
ASP A 197
GLY A 229
SER A 231
 None
 1.14A 4djeB-2dqwA:
21.3		 4djeB-2dqwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 ASP A  70
ASP A 109
ASN A 128
GLY A 229
SER A 231
 None
 1.21A 4djfB-2dqwA:
21.4		 4djfB-2dqwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LYS A 121
LEU A 120
GLU A 117
LEU A 141
 None
 1.43A 4k4yE-2dqwA:
undetectable		 4k4yE-2dqwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 LEU A  69
ASP A  67
VAL A 269
GLU A  64
 None
 0.90A 4zbqA-2dqwA:
undetectable		 4zbqA-2dqwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		5 / 11 VAL A  99
ALA A  58
LEU A  92
ASP A 109
ALA A  54
 None
 1.15A 6dk1A-2dqwA:
0.0		 6dk1A-2dqwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2dqw DIHYDROPTEROATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 VAL A 195
LEU A 266
LEU A  32
LEU A  24
 None
 0.62A 6f6sA-2dqwA:
undetectable
6f6sB-2dqwA:
undetectable		 6f6sA-2dqwA:
15.38
6f6sB-2dqwA:
13.27