SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 372
VAL A 375
LEU A 379
GLN A 382
 None
 0.57A 1fbmE-2dr1A:
undetectable		 1fbmE-2dr1A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 165
ILE A 192
LEU A  66
PHE A  65
GLY A 188
 None
 1.30A 2bxmA-2dr1A:
undetectable		 2bxmA-2dr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 216
ILE A 266
LEU A 270
PHE A  65
GLY A 188
 None
 1.15A 2bxmA-2dr1A:
undetectable		 2bxmA-2dr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 THR A 157
ASP A 182
VAL A 184
SER A 185
LYS A 208
 PLP  A1001 (-2.8A)
PLP  A1001 (-2.8A)
PLP  A1001 (-4.2A)
PLP  A1001 (-3.6A)
PLP  A1001 (-1.4A)
 0.32A 2z9wA-2dr1A:
47.8		 2z9wA-2dr1A:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 THR A 157
ASP A 182
VAL A 184
SER A 185
LYS A 208
 PLP  A1001 (-2.8A)
PLP  A1001 (-2.8A)
PLP  A1001 (-4.2A)
PLP  A1001 (-3.6A)
PLP  A1001 (-1.4A)
 0.33A 2z9wB-2dr1A:
47.9		 2z9wB-2dr1A:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 155
ALA A 306
GLY A 107
ILE A 315
THR A 351
 None
 1.05A 3c6gA-2dr1A:
undetectable		 3c6gA-2dr1A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 4 GLY A 345
GLY A 343
THR A 351
LEU A 305
 None
 0.93A 3si7C-2dr1A:
undetectable
3si7D-2dr1A:
undetectable		 3si7C-2dr1A:
22.47
3si7D-2dr1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A  85
GLY A  82
TYR A 110
ASP A 182
 None
None
None
PLP  A1001 (-2.8A)
 1.07A 3w9tD-2dr1A:
undetectable		 3w9tD-2dr1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 365
ILE A 273
TRP A 282
MET A 285
 None
 1.45A 3welA-2dr1A:
undetectable		 3welA-2dr1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 238
THR A 257
TYR A 244
TRP A 237
 None
 1.34A 3wipD-2dr1A:
undetectable
3wipE-2dr1A:
undetectable		 3wipD-2dr1A:
19.17
3wipE-2dr1A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 164
GLU A 167
VAL A 150
ILE A 152
GLU A 174
 None
 1.25A 4a99A-2dr1A:
2.3
4a99C-2dr1A:
2.3		 4a99A-2dr1A:
21.56
4a99C-2dr1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 300
LEU A 372
ILE A 304
GLY A 326
 None
 0.72A 4hb8A-2dr1A:
undetectable		 4hb8A-2dr1A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 344
LEU A 305
GLU A 156
VAL A 132
 None
 1.31A 4nkvA-2dr1A:
undetectable		 4nkvA-2dr1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 MET A  56
GLU A 252
TYR A 247
GLU A 250
 None
 1.27A 4r87J-2dr1A:
0.0
4r87L-2dr1A:
0.0		 4r87J-2dr1A:
17.53
4r87L-2dr1A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 SER A 256
GLY A  82
GLN A 262
GLY A 215
PRO A 259
 None
 1.09A 4uilH-2dr1A:
undetectable
4uilL-2dr1A:
undetectable		 4uilH-2dr1A:
20.05
4uilL-2dr1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A 266
ASN A 267
ILE A  38
VAL A  35
 None
 1.22A 4uy87-2dr1A:
undetectable		 4uy87-2dr1A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 178
ILE A 228
ALA A 229
ALA A  86
 None
 0.75A 4zf8A-2dr1A:
undetectable		 4zf8A-2dr1A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 116
GLY A 107
THR A 157
GLU A 156
 None
None
PLP  A1001 (-2.8A)
None
 1.05A 5btiA-2dr1A:
undetectable
5btiB-2dr1A:
undetectable		 5btiA-2dr1A:
23.32
5btiB-2dr1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 116
GLY A 107
THR A 157
GLU A 156
 None
None
PLP  A1001 (-2.8A)
None
 1.08A 5btiC-2dr1A:
undetectable
5btiD-2dr1A:
undetectable		 5btiC-2dr1A:
23.32
5btiD-2dr1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 4 VAL A  29
ALA A 209
ILE A 315
THR A 314
 None
 1.12A 5e4dB-2dr1A:
undetectable		 5e4dB-2dr1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 189
TYR A 359
PHE A  24
PHE A  32
THR A 314
 None
 1.30A 5eslA-2dr1A:
undetectable		 5eslA-2dr1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A  80
THR A  81
SER A 205
VAL A 184
 PLP  A1001 (-3.7A)
PLP  A1001 (-3.6A)
PLP  A1001 (-2.7A)
PLP  A1001 (-4.2A)
 1.06A 5ewuA-2dr1A:
2.6		 5ewuA-2dr1A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 9 MET A 368
GLY A 326
ALA A 332
MET A 333
ILE A 324
 None
 1.32A 5i3cA-2dr1A:
undetectable		 5i3cA-2dr1A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A  29
LEU A 270
THR A  58
GLY A 215
LEU A 216
 None
 1.30A 5m50E-2dr1A:
3.2		 5m50E-2dr1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 189
TYR A 359
PHE A  24
PHE A  32
THR A 314
 None
 1.25A 6e8qA-2dr1A:
undetectable		 6e8qA-2dr1A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 287
LEU A 369
HIS A 356
ILE A 354
THR A 316
 None
 1.46A 6fzbB-2dr1A:
undetectable		 6fzbB-2dr1A:
11.40