SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		4 / 8 ALA A 129
GLY A  84
VAL A  89
ILE A  55
 None
 0.70A 1d4yB-2dr3A:
undetectable		 1d4yB-2dr3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		5 / 9 ALA A 123
GLY A  54
ALA A 129
LEU A 159
LEU A 120
 None
 1.13A 1nr6A-2dr3A:
undetectable		 1nr6A-2dr3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		5 / 12 VAL A 209
ILE A 167
VAL A 188
THR A   7
LEU A 207
 None
 0.90A 1r9oA-2dr3A:
undetectable		 1r9oA-2dr3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		3 / 3 LEU A  28
PHE A  39
ARG A   4
 None
 0.70A 1xdkB-2dr3A:
undetectable		 1xdkB-2dr3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		4 / 6 LEU A  28
TRP A  75
MET A  70
MET A  88
 None
 1.38A 2oz7A-2dr3A:
undetectable		 2oz7A-2dr3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		4 / 8 VAL A 172
GLY A 180
ILE A 191
GLY A  30
 None
 0.80A 3n9jB-2dr3A:
undetectable		 3n9jB-2dr3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		3 / 3 GLY A  33
GLY A  35
THR A  37
 ADP  A3801 (-3.4A)
ADP  A3801 (-2.9A)
ADP  A3801 (-3.5A)
 0.43A 3si7B-2dr3A:
7.2		 3si7B-2dr3A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		5 / 12 PHE A  39
THR A  34
VAL A 172
ILE A 192
VAL A  12
 None
ADP  A3801 (-4.2A)
None
None
None
 1.46A 3sp6A-2dr3A:
0.0		 3sp6A-2dr3A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		4 / 6 SER A 216
MET A 212
THR A 215
ARG A   4
 None
 1.14A 3thrB-2dr3A:
3.6		 3thrB-2dr3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		4 / 7 PRO A  10
ILE A   9
GLN A  42
GLY A 230
 None
 0.94A 4a3uB-2dr3A:
2.8		 4a3uB-2dr3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		5 / 12 PHE A  39
LEU A  16
GLY A  11
ILE A 231
VAL A 233
 None
 0.99A 4a6dA-2dr3A:
undetectable		 4a6dA-2dr3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		5 / 12 PHE A  39
LEU A  16
GLY A  11
ILE A 231
VAL A 233
 None
 0.97A 4a6eA-2dr3A:
undetectable		 4a6eA-2dr3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		4 / 8 ALA A 129
GLY A  84
VAL A  89
ILE A  55
 None
 0.75A 4ll3A-2dr3A:
undetectable		 4ll3A-2dr3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		5 / 11 ASN A  69
ILE A  38
THR A 227
GLY A 230
THR A  37
 None
ADP  A3801 (-4.3A)
None
None
ADP  A3801 (-3.5A)
 1.41A 4xt7A-2dr3A:
undetectable		 4xt7A-2dr3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		3 / 3 PHE A  86
ARG A  67
ALA A  58
 None
 0.93A 6ecfB-2dr3A:
undetectable		 6ecfB-2dr3A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2dr3 UPF0273 PROTEIN
PH0284
(Pyrococcus
horikoshii) 		4 / 6 ALA A 129
GLY A 161
ILE A 117
PHE A 116
 None
 0.90A 6f8cA-2dr3A:
undetectable		 6f8cA-2dr3A:
14.98