SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		4 / 7 LEU A 160
ILE A  81
SER A  65
TYR A 139
 None
 1.01A 2hc4A-2dreA:
undetectable		 2hc4A-2dreA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		5 / 10 LEU A 158
SER A 149
ILE A 173
PRO A  25
SER A  27
 None
 1.43A 3ik6B-2dreA:
undetectable
3ik6E-2dreA:
undetectable		 3ik6B-2dreA:
23.75
3ik6E-2dreA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		4 / 6 ASN A  80
PHE A 122
ALA A  82
THR A  97
 None
 0.76A 3t3sB-2dreA:
undetectable		 3t3sB-2dreA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		4 / 8 ASN A  80
PHE A 122
ALA A  82
THR A  97
 None
 0.83A 3t3sD-2dreA:
undetectable		 3t3sD-2dreA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		4 / 8 ASN A  80
PHE A 122
ALA A  82
THR A  97
 None
 0.82A 3t3sF-2dreA:
undetectable		 3t3sF-2dreA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		4 / 6 ALA A  37
LEU A 153
SER A 152
VAL A  35
 CLA  A1001 (-3.5A)
None
None
CLA  A1001 (-4.1A)
 1.03A 5a6iA-2dreA:
undetectable		 5a6iA-2dreA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		5 / 12 PRO A  25
SER A 149
GLY A 148
PHE A 171
LEU A  34
 None
 1.41A 5eeiA-2dreA:
undetectable		 5eeiA-2dreA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		5 / 12 PRO A  25
SER A 149
GLY A 148
PHE A 171
LEU A  34
 None
 1.40A 5eeiB-2dreA:
undetectable		 5eeiB-2dreA:
16.89