SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2drh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 280
ALA A  71
LEU A 132
ILE A  55
LEU A  98
 None
 1.18A 1ddsA-2drhA:
undetectable		 1ddsA-2drhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 280
ALA A  71
LEU A 132
ILE A  55
LEU A  98
 None
 1.11A 1ddsB-2drhA:
undetectable		 1ddsB-2drhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 206
VAL A 205
ILE A  21
VAL A  29
PHE A 165
 None
 1.42A 1gx9A-2drhA:
undetectable		 1gx9A-2drhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 GLU A 166
GLY A 171
THR A  53
HIS A  31
GLY A 184
 None
 1.35A 1i7qA-2drhA:
undetectable		 1i7qA-2drhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 GLY A 252
GLN A 254
VAL A 258
SER A 285
 None
 1.32A 1p6kB-2drhA:
undetectable		 1p6kB-2drhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 GLY A 252
GLN A 254
VAL A 258
SER A 285
 None
 1.30A 1rs6B-2drhA:
undetectable		 1rs6B-2drhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 GLY A 252
GLN A 254
VAL A 258
SER A 285
 None
 1.32A 1zzuB-2drhA:
undetectable		 1zzuB-2drhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 THR A  53
ALA A  54
ALA A 157
VAL A 149
ALA A 107
 None
 1.03A 2f16K-2drhA:
undetectable
2f16L-2drhA:
undetectable		 2f16K-2drhA:
21.64
2f16L-2drhA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 THR A  53
ALA A  54
ALA A 157
VAL A 149
ALA A 107
 None
 1.03A 2f16Y-2drhA:
undetectable
2f16Z-2drhA:
undetectable		 2f16Y-2drhA:
21.64
2f16Z-2drhA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 GLU A 166
GLY A 171
THR A  53
HIS A  31
GLY A 184
 None
 1.19A 2fn1B-2drhA:
undetectable		 2fn1B-2drhA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 6 ASN A 100
ILE A 104
VAL A 133
ALA A 107
 None
 0.97A 2j5mA-2drhA:
undetectable		 2j5mA-2drhA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 GLY A 210
ARG A 211
TYR A 274
TYR A 272
 None
 1.00A 2wb9A-2drhA:
0.0		 2wb9A-2drhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		3 / 3 MET A 242
VAL A  27
GLU A 167
 None
 0.91A 2x9gA-2drhA:
undetectable		 2x9gA-2drhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1468_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 LYS A  66
GLU A  93
THR A  94
TYR A  63
 None
 1.32A 2xrzA-2drhA:
0.0		 2xrzA-2drhA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 280
ALA A  71
LEU A 132
ILE A  55
LEU A  98
 None
 1.30A 2zzaA-2drhA:
undetectable		 2zzaA-2drhA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 280
ALA A  71
LEU A 132
ILE A  55
LEU A  98
 None
 1.29A 2zzaB-2drhA:
undetectable		 2zzaB-2drhA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A  90
THR A  91
GLY A  70
ALA A  69
 None
 0.75A 3aruA-2drhA:
undetectable		 3aruA-2drhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 327
ALA A 322
GLY A 168
ILE A 323
SER A 207
 None
 1.29A 3gyqA-2drhA:
undetectable
3gyqB-2drhA:
undetectable		 3gyqA-2drhA:
23.06
3gyqB-2drhA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 327
ALA A 322
GLY A 168
ILE A 323
SER A 207
 None
 1.24A 3gyqB-2drhA:
undetectable		 3gyqB-2drhA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  10
ALA A 318
SER A 326
SER A 207
ILE A 324
 None
 1.21A 3qgtB-2drhA:
2.1		 3qgtB-2drhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 280
ALA A 259
LEU A  86
ILE A  96
ILE A 241
 None
 1.25A 3ql3A-2drhA:
undetectable		 3ql3A-2drhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 115
LEU A 112
VAL A  81
GLY A  82
 None
 0.84A 3w1wA-2drhA:
undetectable		 3w1wA-2drhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 280
ALA A  71
LEU A 132
ILE A  55
LEU A  98
 None
 1.09A 4gh8A-2drhA:
undetectable		 4gh8A-2drhA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 303
ILE A 194
THR A 315
ALA A 245
VAL A 201
 None
 1.06A 4nkxC-2drhA:
undetectable		 4nkxC-2drhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 303
ILE A 194
THR A 315
ALA A 245
VAL A 201
 None
 1.08A 4nkxD-2drhA:
undetectable		 4nkxD-2drhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 280
ALA A  71
LEU A 132
ILE A  55
LEU A  98
 None
 1.17A 4rgcA-2drhA:
undetectable		 4rgcA-2drhA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 ARG A  49
GLY A  37
GLY A  46
PRO A  47
 None
 0.87A 4u9uA-2drhA:
undetectable		 4u9uA-2drhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 7 PRO A  80
ILE A  96
PHE A 284
VAL A 282
ILE A 280
 None
 1.09A 5bmvC-2drhA:
undetectable		 5bmvC-2drhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 213
GLY A 223
LEU A 266
GLY A 210
PHE A 181
 None
 1.14A 5vooF-2drhA:
undetectable		 5vooF-2drhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		4 / 7 ALA A 314
THR A 315
ILE A 194
VAL A 192
 None
 0.88A 6cduF-2drhA:
undetectable
6cduJ-2drhA:
undetectable		 6cduF-2drhA:
22.25
6cduJ-2drhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 104
VAL A 282
ALA A  71
LEU A 134
LEU A 132
 None
 0.99A 6f6nA-2drhA:
undetectable
6f6nB-2drhA:
undetectable		 6f6nA-2drhA:
12.01
6f6nB-2drhA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A  19
ILE A 244
THR A  53
PHE A 165
HIS A  31
 None
 1.30A 6j20A-2drhA:
undetectable		 6j20A-2drhA:
20.72