SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2drm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		4 / 4 GLY A  38
ASP A  35
GLY A  49
THR A  17
 None
 0.98A 1hxbB-2drmA:
undetectable		 1hxbB-2drmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 0.98A 2wa2B-2drmA:
undetectable		 2wa2B-2drmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		4 / 4 GLY A  38
ASP A  35
GLY A  49
THR A  17
 None
 0.97A 3k4vC-2drmA:
undetectable		 3k4vC-2drmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		4 / 6 VAL A  51
ALA A  53
VAL A  56
TYR A  55
 None
 1.06A 5i8fA-2drmA:
undetectable		 5i8fA-2drmA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 0.93A 5njvD-2drmA:
undetectable		 5njvD-2drmA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 1.01A 5wz1A-2drmA:
undetectable		 5wz1A-2drmA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 1.01A 5wz1C-2drmA:
undetectable		 5wz1C-2drmA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 1.01A 5wz1D-2drmA:
undetectable		 5wz1D-2drmA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 1.00A 5wz1E-2drmA:
undetectable		 5wz1E-2drmA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 1.02A 5wz1F-2drmA:
undetectable		 5wz1F-2drmA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 1.00A 5wz1G-2drmA:
undetectable		 5wz1G-2drmA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2drm ACANTHAMOEBA MYOSIN
IB
(Acanthamoeba) 		5 / 12 GLY A  38
GLY A  42
TRP A  40
GLU A  20
ILE A  29
 None
 1.00A 5wz1H-2drmA:
undetectable		 5wz1H-2drmA:
12.25