SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2drq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		5 / 12 ALA A 134
LEU A 206
PHE A 203
PHE A 376
LEU A 273
 None
 0.98A 1ao8A-2drqA:
undetectable		 1ao8A-2drqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 GLU A 130
LEU A 161
THR A  95
TYR A 100
 None
 1.18A 1rmtB-2drqA:
undetectable		 1rmtB-2drqA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 PHE A 260
TYR A 265
LEU A 323
TYR A 306
 None
 1.18A 1rmtB-2drqA:
undetectable		 1rmtB-2drqA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		5 / 8 ARG A 266
LEU A 364
ASP A 361
ILE A  48
GLY A  63
 None
 1.18A 2o4nB-2drqA:
undetectable		 2o4nB-2drqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 ILE A  87
ASP A  42
GLY A  41
PHE A  40
 None
 0.89A 2tsrA-2drqA:
undetectable		 2tsrA-2drqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		3 / 3 GLY A 263
TYR A 265
SER A 264
 None
 0.68A 2xatA-2drqA:
undetectable		 2xatA-2drqA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2drq XYLANASE Y
(Bacillus
halodurans) 		5 / 12 ILE A 291
SER A 226
ALA A 223
LEU A 200
ILE A 271
 None
 1.27A 2xkwB-2drqA:
undetectable		 2xkwB-2drqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 8 TYR A  50
VAL A  52
ARG A  90
VAL A  67
 None
 1.23A 2y05A-2drqA:
undetectable
2y05B-2drqA:
undetectable		 2y05A-2drqA:
22.79
2y05B-2drqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 PRO A 381
PHE A   9
ILE A 378
TRP A 210
 None
 0.97A 2y7kA-2drqA:
undetectable		 2y7kA-2drqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 6 GLU A 131
TYR A 132
SER A 226
ASP A 195
 None
 1.35A 2zvjA-2drqA:
undetectable		 2zvjA-2drqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2drq XYLANASE Y
(Bacillus
halodurans) 		3 / 3 MET A 101
GLU A 130
ASP A 128
 None
 1.10A 3a25A-2drqA:
undetectable		 3a25A-2drqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 8 ILE A 291
ALA A 241
LEU A 240
PRO A 196
 None
 0.83A 3ozwA-2drqA:
undetectable		 3ozwA-2drqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 8 ASP A  61
GLY A  63
GLU A  70
ARG A 353
 None
 1.02A 3s3nA-2drqA:
undetectable		 3s3nA-2drqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 THR A 326
GLY A 330
ALA A 268
ILE A 291
 None
 0.72A 4txnA-2drqA:
undetectable		 4txnA-2drqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 THR A 326
GLY A 330
ALA A 268
ILE A 291
 None
 0.75A 4txnB-2drqA:
undetectable		 4txnB-2drqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 THR A 326
GLY A 330
ALA A 268
ILE A 291
 None
 0.77A 4txnC-2drqA:
undetectable		 4txnC-2drqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 THR A 326
GLY A 330
ALA A 268
ILE A 291
 None
 0.75A 4txnD-2drqA:
undetectable		 4txnD-2drqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2drq XYLANASE Y
(Bacillus
halodurans) 		4 / 7 ILE A  87
ASP A  42
GLY A  41
PHE A  40
 None
 0.92A 5h3aA-2drqA:
undetectable		 5h3aA-2drqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 2drq XYLANASE Y
(Bacillus
halodurans) 		3 / 3 HIS A 163
ASP A 215
HIS A 167
 None
 0.73A 5n1tW-2drqA:
undetectable		 5n1tW-2drqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2drq XYLANASE Y
(Bacillus
halodurans) 		3 / 3 TYR A 365
ALA A 371
LEU A 372
 None
 0.60A 6ag0C-2drqA:
undetectable		 6ag0C-2drqA:
15.91