SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2drw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 11 LEU A 294
HIS A  71
LEU A 181
LEU A 265
ILE A 177
 None
 1.37A 1ee2A-2drwA:
undetectable		 1ee2A-2drwA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 5 LEU A  27
GLU A  32
ALA A 326
LEU A 328
 None
 1.07A 1eta2-2drwA:
undetectable		 1eta2-2drwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 9 THR A 190
LEU A 236
GLU A 114
ALA A 242
LEU A 308
 None
 1.35A 2azqA-2drwA:
undetectable		 2azqA-2drwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 9 LEU A 259
PHE A 255
LEU A 265
LEU A  72
ALA A  67
 None
 0.99A 2bxeA-2drwA:
undetectable		 2bxeA-2drwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 10 LEU A 259
PHE A 255
LEU A 265
LEU A  72
ALA A  67
 None
 1.05A 2bxeB-2drwA:
undetectable		 2bxeB-2drwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 5 THR A 324
SER A 302
ASP A 321
SER A 301
 None
 1.27A 2hdnA-2drwA:
undetectable
2hdnB-2drwA:
undetectable
2hdnD-2drwA:
undetectable		 2hdnA-2drwA:
9.25
2hdnB-2drwA:
20.21
2hdnD-2drwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 5 SER A 301
THR A 324
SER A 302
ASP A 321
 None
 1.28A 2hdnB-2drwA:
undetectable
2hdnC-2drwA:
undetectable
2hdnD-2drwA:
undetectable		 2hdnB-2drwA:
20.21
2hdnC-2drwA:
9.25
2hdnD-2drwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 6 THR A 324
SER A 302
ASP A 321
SER A 301
 None
 1.28A 2hdnI-2drwA:
undetectable
2hdnJ-2drwA:
undetectable
2hdnL-2drwA:
undetectable		 2hdnI-2drwA:
9.25
2hdnJ-2drwA:
20.21
2hdnL-2drwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 6 SER A 301
THR A 324
SER A 302
ASP A 321
 None
 1.28A 2hdnJ-2drwA:
undetectable
2hdnK-2drwA:
undetectable
2hdnL-2drwA:
undetectable		 2hdnJ-2drwA:
20.21
2hdnK-2drwA:
9.25
2hdnL-2drwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1289_1
(FICOLIN-2)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 4 ARG A 250
ASP A 251
THR A 248
LYS A 254
 None
 1.01A 2j2pB-2drwA:
0.0		 2j2pB-2drwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1290_1
(FICOLIN-2)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 4 ARG A 250
ASP A 251
THR A 248
LYS A 254
 None
 1.13A 2j2pC-2drwA:
0.0		 2j2pC-2drwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 6 ARG A 250
ASP A 251
THR A 248
LYS A 254
 None
 1.06A 2j2pE-2drwA:
undetectable
2j2pF-2drwA:
undetectable		 2j2pE-2drwA:
21.33
2j2pF-2drwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 8 ASN A 286
GLY A 300
ILE A  11
VAL A 347
 None
 0.94A 2yoeB-2drwA:
undetectable
2yoeC-2drwA:
undetectable		 2yoeB-2drwA:
23.08
2yoeC-2drwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 10 ALA A 326
LEU A 304
LEU A 294
PHE A 260
THR A 324
 None
 1.17A 3jw5B-2drwA:
undetectable		 3jw5B-2drwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 7 ILE A 264
LEU A  72
ALA A  67
MET A 273
 None
 0.84A 3r9tB-2drwA:
undetectable		 3r9tB-2drwA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 4 ASP A 185
ASP A 251
GLY A  52
THR A  34
 None
 1.34A 3tl9B-2drwA:
undetectable		 3tl9B-2drwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 8 LEU A  27
GLU A  32
ALA A 326
LEU A 328
 None
 0.96A 4iizB-2drwA:
undetectable		 4iizB-2drwA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 12 LEU A 256
SER A 316
ILE A 317
LEU A 304
THR A  68
 None
 1.15A 4ky8D-2drwA:
undetectable		 4ky8D-2drwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 6 SER A 301
GLU A 356
ASP A 321
ASP A 352
 None
 1.02A 4uckB-2drwA:
undetectable		 4uckB-2drwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 5 LEU A 103
ALA A 241
VAL A 131
ILE A 130
 None
 0.94A 4xe3A-2drwA:
undetectable		 4xe3A-2drwA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 5 SER A  64
ALA A  67
HIS A 307
LEU A 294
 None
 1.36A 5dzkb-2drwA:
undetectable
5dzkp-2drwA:
undetectable		 5dzkb-2drwA:
20.65
5dzkp-2drwA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 5 SER A  64
ALA A  67
HIS A 307
LEU A 294
 None
 1.38A 5dzkc-2drwA:
undetectable
5dzkq-2drwA:
undetectable		 5dzkc-2drwA:
20.65
5dzkq-2drwA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		6 / 12 ILE A  11
GLY A  10
LEU A  27
LEU A  29
ASN A   5
LEU A   4
 None
 1.31A 5nfjA-2drwA:
undetectable		 5nfjA-2drwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 12 ILE A  11
GLY A  10
LEU A  29
ASN A   5
LEU A   4
 None
 1.07A 5nfjB-2drwA:
undetectable		 5nfjB-2drwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 12 ILE A  11
GLY A  10
LEU A  27
LEU A  29
ASN A   5
 None
 1.16A 5nfjC-2drwA:
undetectable		 5nfjC-2drwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 12 ILE A  11
GLY A  10
LEU A  29
ASN A   5
LEU A   4
 None
 1.07A 5nfjC-2drwA:
undetectable		 5nfjC-2drwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 12 ALA A 242
GLY A 243
SER A  60
LEU A 156
ASP A 112
 None
 1.09A 5w7pA-2drwA:
undetectable		 5w7pA-2drwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 12 VAL A 347
GLY A 243
PHE A 194
THR A 231
GLY A 202
 None
 1.20A 6brdC-2drwA:
undetectable		 6brdC-2drwA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		3 / 3 ARG A  18
HIS A  15
ARG A 353
 None
 0.92A 6dwdD-2drwA:
undetectable		 6dwdD-2drwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 11 MET A 183
PHE A 255
LEU A 259
ILE A  58
MET A 245
 None
 1.31A 6fgcA-2drwA:
undetectable		 6fgcA-2drwA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		5 / 12 ASP A 244
VAL A 188
SER A 247
PHE A 178
TYR A 169
 None
 1.38A 6h7mB-2drwA:
undetectable		 6h7mB-2drwA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2drw D-AMINO ACID AMIDASE
(Ochrobactrum
anthropi) 		4 / 7 GLY A 153
TYR A 154
ASN A 105
GLY A 293
 None
 0.95A 6n7fA-2drwA:
undetectable		 6n7fA-2drwA:
13.13