SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 10 LEU A 396
VAL A 370
VAL A 368
GLY A 369
LEU A 400
 None
 1.43A 1fk9A-2dsjA:
undetectable		 1fk9A-2dsjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 10 LEU A 396
VAL A 370
VAL A 368
GLY A 369
LEU A 400
 None
 1.20A 1fkoA-2dsjA:
undetectable		 1fkoA-2dsjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 8 GLU A 326
LEU A 396
ALA A 399
LEU A 400
 None
 0.76A 1hwiD-2dsjA:
undetectable		 1hwiD-2dsjA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 9 LEU A 396
VAL A 370
VAL A 368
GLY A 369
LEU A 400
 None
 1.29A 1lwfA-2dsjA:
undetectable		 1lwfA-2dsjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 268
LEU A 274
ALA A 275
LEU A  98
LEU A 259
 None
 0.94A 1s9pB-2dsjA:
undetectable		 1s9pB-2dsjA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 12 ALA A 245
GLY A 243
ASP A  88
LEU A 242
GLY A 247
 None
 1.07A 2f8lA-2dsjA:
undetectable		 2f8lA-2dsjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 159
ALA A 157
ALA A 180
LEU A  50
ILE A 223
 None
 1.04A 2h42C-2dsjA:
0.0		 2h42C-2dsjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 6 LEU A  56
VAL A 199
VAL A 231
ILE A 183
ARG A 214
 None
 1.49A 2hyyA-2dsjA:
undetectable		 2hyyA-2dsjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		3 / 3 VAL A 380
GLU A 335
GLU A 381
 None
 0.65A 2nv4A-2dsjA:
undetectable		 2nv4A-2dsjA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 4 ARG A  11
GLY A  13
GLU A  12
SER A 175
 None
 1.29A 2xctS-2dsjA:
0.9
2xctU-2dsjA:
undetectable		 2xctS-2dsjA:
23.35
2xctU-2dsjA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 6 TYR A 390
ALA A 325
LEU A 324
ALA A 249
 None
 0.89A 3b6hB-2dsjA:
undetectable		 3b6hB-2dsjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 10 LEU A 396
VAL A 370
VAL A 368
GLY A 369
LEU A 400
 None
 1.44A 3lp1A-2dsjA:
undetectable		 3lp1A-2dsjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 ASP A 198
SER A  83
GLY A  84
ASP A  88
 None
 1.20A 3w9tB-2dsjA:
undetectable		 3w9tB-2dsjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 ASP A 198
SER A  83
GLY A  84
ASP A  88
 None
 1.20A 3w9tC-2dsjA:
undetectable		 3w9tC-2dsjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 ASP A 198
SER A  83
GLY A  84
ASP A  88
 None
 1.19A 3w9tD-2dsjA:
undetectable		 3w9tD-2dsjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 8 ARG A 331
LEU A 330
ARG A 404
GLU A 333
 None
 1.35A 3zmdA-2dsjA:
undetectable
3zmdB-2dsjA:
undetectable		 3zmdA-2dsjA:
17.18
3zmdB-2dsjA:
17.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		7 / 11 TYR A 164
ARG A 167
VAL A 173
ILE A 179
SER A 182
LYS A 186
LEU A 216
 None
None
CL  A1002 (-3.9A)
None
None
None
None
 0.34A 4lhmA-2dsjA:
51.5		 4lhmA-2dsjA:
41.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 PHE A 105
PRO A  77
VAL A  78
ALA A 106
 None
 1.24A 4w5oA-2dsjA:
3.7		 4w5oA-2dsjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 11 LEU A  71
GLY A 146
LEU A 147
ASP A  79
PHE A 305
 None
 1.35A 4wnuC-2dsjA:
undetectable		 4wnuC-2dsjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 PHE A 105
PRO A  77
VAL A  78
ALA A 106
 None
 1.24A 4z4cA-2dsjA:
undetectable		 4z4cA-2dsjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 PHE A 105
PRO A  77
VAL A  78
ALA A 106
 None
 1.26A 4z4dA-2dsjA:
undetectable		 4z4dA-2dsjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 PHE A 105
PRO A  77
VAL A  78
ALA A 106
 None
 1.26A 4z4eA-2dsjA:
undetectable		 4z4eA-2dsjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 120
ALA A 258
ALA A 255
VAL A 252
LEU A 259
 None
 1.45A 5igpA-2dsjA:
1.4		 5igpA-2dsjA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 5 ALA A  45
GLY A  13
LYS A  15
HIS A  16
 None
 1.27A 5jt4A-2dsjA:
undetectable		 5jt4A-2dsjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 259
ILE A 120
THR A 119
TRP A 129
 None
 1.16A 5ljcA-2dsjA:
undetectable		 5ljcA-2dsjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		4 / 8 LEU A 147
ALA A 255
VAL A 145
GLN A 309
 None
 0.91A 5nu7A-2dsjA:
undetectable		 5nu7A-2dsjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE
(Thermus
thermophilus) 		5 / 10 VAL A 201
GLY A 202
GLY A 204
THR A 209
ALA A 213
 None
 1.00A 5vm8B-2dsjA:
undetectable		 5vm8B-2dsjA:
21.15