SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 11 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A 100
 None
 1.06A 1mx1A-2dstA:
undetectable		 1mx1A-2dstA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A 100
 None
 0.97A 1mx1C-2dstA:
2.2		 1mx1C-2dstA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		6 / 12 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A  26
LEU A 100
 None
 1.19A 1mx1D-2dstA:
5.6		 1mx1D-2dstA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		6 / 12 GLY A  72
VAL A  28
LEU A  48
LEU A 102
LEU A  26
LEU A 100
 None
 1.21A 1mx1F-2dstA:
3.6		 1mx1F-2dstA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 9 ALA A  67
ALA A  92
GLY A  90
GLY A  94
HIS A  96
 None
 1.18A 2v7bA-2dstA:
3.1		 2v7bA-2dstA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 9 ALA A  67
ALA A  92
GLY A  90
GLY A  94
HIS A  96
 None
 1.18A 2v7bB-2dstA:
3.1		 2v7bB-2dstA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 8 LEU A   9
LEU A  14
PRO A  51
LEU A  66
ALA A  67
 None
 1.32A 2vcvF-2dstA:
undetectable		 2vcvF-2dstA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 9 ALA A  67
ALA A  92
GLY A  90
GLY A  94
HIS A  96
 None
 1.15A 4eatB-2dstA:
3.4		 4eatB-2dstA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  48
VAL A  70
GLY A  72
ALA A  74
LEU A  79
 None
 1.12A 4rrwA-2dstA:
undetectable		 4rrwA-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  48
VAL A  70
GLY A  72
ALA A  74
LEU A  79
 None
 1.12A 4rrwB-2dstA:
undetectable		 4rrwB-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  26
LEU A   9
VAL A  70
GLY A  72
ALA A  71
 None
 1.03A 4rrwC-2dstA:
undetectable		 4rrwC-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  26
LEU A   9
VAL A  70
GLY A  72
ALA A  71
 None
 0.97A 4rrxA-2dstA:
undetectable		 4rrxA-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  26
LEU A   9
VAL A  70
GLY A  72
ALA A  71
 None
 0.98A 4rrxB-2dstA:
undetectable		 4rrxB-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  48
VAL A  70
GLY A  72
ALA A  74
LEU A  79
 None
 1.12A 4rrzA-2dstA:
undetectable		 4rrzA-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  48
VAL A  70
GLY A  72
ALA A  74
LEU A  79
 None
 1.12A 4rrzB-2dstA:
undetectable		 4rrzB-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  26
LEU A   9
VAL A  70
GLY A  72
ALA A  71
 None
 1.03A 4rrzC-2dstA:
undetectable		 4rrzC-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		4 / 4 VAL A 110
GLY A 109
ARG A  87
VAL A 112
 None
 1.36A 5d4nA-2dstA:
0.0
5d4nB-2dstA:
undetectable		 5d4nA-2dstA:
26.67
5d4nB-2dstA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 LEU A  48
VAL A  70
GLY A  72
ALA A  74
LEU A  79
 None
 1.15A 5ikrA-2dstA:
undetectable		 5ikrA-2dstA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		6 / 12 LEU A   9
MET A  76
VAL A  75
GLY A  72
ALA A  71
LEU A 100
 None
 1.30A 5iktA-2dstA:
undetectable		 5iktA-2dstA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2dst HYPOTHETICAL PROTEIN
TTHA1544
(Thermus
thermophilus) 		5 / 12 VAL A  25
PHE A  45
GLY A  22
LEU A 120
LEU A 116
 None
 1.18A 5x23A-2dstA:
undetectable		 5x23A-2dstA:
14.25