SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.36A 1a52A-2dt8A:
undetectable		 1a52A-2dt8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.37A 1a52B-2dt8A:
undetectable		 1a52B-2dt8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 9 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1ereA-2dt8A:
undetectable		 1ereA-2dt8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 9 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1ereB-2dt8A:
undetectable		 1ereB-2dt8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 9 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.41A 1ereD-2dt8A:
undetectable		 1ereD-2dt8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A 159
LEU A 165
GLY A 271
PRO A 270
PHE A  49
 None
 1.38A 1fdsA-2dt8A:
undetectable		 1fdsA-2dt8A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  13
PRO A  14
LEU A  17
 None
 0.50A 1hrkA-2dt8A:
1.7		 1hrkA-2dt8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 TRP A  40
ILE A  48
ILE A  88
ALA A 118
THR A 272
 None
None
None
PLM  A 701 ( 4.0A)
None
 1.10A 1jtxA-2dt8A:
undetectable		 1jtxA-2dt8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1qkuA-2dt8A:
undetectable		 1qkuA-2dt8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.43A 1qkuB-2dt8A:
undetectable		 1qkuB-2dt8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.42A 1qkuC-2dt8A:
undetectable		 1qkuC-2dt8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 7 TYR A 278
HIS A 153
TYR A 228
TYR A 276
 None
GOL  A 601 (-3.5A)
None
PLM  A 701 (-4.6A)
 1.10A 2ombC-2dt8A:
undetectable
2ombD-2dt8A:
undetectable		 2ombC-2dt8A:
21.99
2ombD-2dt8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 5 VAL A  25
THR A   7
VAL A 126
GLY A 123
 None
 1.13A 2p2fA-2dt8A:
2.8		 2p2fA-2dt8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 4 VAL A  25
THR A   7
VAL A 126
GLY A 123
 None
 1.12A 2p2fB-2dt8A:
undetectable		 2p2fB-2dt8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  17
LEU A  21
LEU A 256
GLU A 254
 None
 0.90A 2vq5B-2dt8A:
undetectable		 2vq5B-2dt8A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  28
ILE A  88
PHE A  69
VAL A 112
VAL A 110
 None
 0.93A 2ygnA-2dt8A:
undetectable		 2ygnA-2dt8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 4 SER A  65
PRO A  66
PHE A  69
PRO A  64
 None
 1.47A 3bjwA-2dt8A:
0.0		 3bjwA-2dt8A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 4 SER A  65
PRO A  66
PHE A  69
PRO A  64
 None
 1.49A 3bjwG-2dt8A:
0.0		 3bjwG-2dt8A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 4 SER A  65
PRO A  66
PHE A  69
PRO A  64
 None
 1.49A 3bjwD-2dt8A:
0.0		 3bjwD-2dt8A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 VAL A 122
VAL A  96
SER A  93
 None
None
PLM  A 701 (-2.5A)
 0.71A 3n8xB-2dt8A:
undetectable		 3n8xB-2dt8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 6 VAL A 142
LEU A 139
ILE A   3
VAL A 113
 None
 0.95A 4a9kA-2dt8A:
0.0		 4a9kA-2dt8A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 LYS A 191
THR A 189
ILE A 211
 GOL  A 601 (-2.9A)
GOL  A 601 (-4.0A)
None
 0.88A 4e0fB-2dt8A:
undetectable		 4e0fB-2dt8A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 7 ASP A  39
THR A  44
ASN A 258
LEU A 120
 None
 0.76A 4ib4A-2dt8A:
undetectable		 4ib4A-2dt8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 ILE A 264
ASP A  39
ARG A 170
 PLM  A 701 ( 4.5A)
None
PLM  A 701 (-4.1A)
 0.83A 4pstA-2dt8A:
undetectable		 4pstA-2dt8A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 VAL A  83
TYR A  73
ALA A  76
 None
 0.51A 4ybnA-2dt8A:
undetectable		 4ybnA-2dt8A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2dt8 DEGV FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 SER A  11
THR A 111
LEU A 127
LEU A  21
VAL A  23
 None
 1.22A 6a93B-2dt8A:
undetectable		 6a93B-2dt8A:
21.48