SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dt9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		4 / 8 ASP A  26
GLY A  29
ALA A  31
GLN A  50
 None
 0.22A 2dtjA-2dt9A:
21.3
2dtjB-2dt9A:
21.5		 2dtjA-2dt9A:
40.56
2dtjB-2dt9A:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		5 / 9 ILE A  24
ASP A  26
GLY A  29
ALA A  31
GLN A  50
 None
 0.65A 2dtjA-2dt9A:
21.3
2dtjB-2dt9A:
21.5		 2dtjA-2dt9A:
40.56
2dtjB-2dt9A:
40.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		4 / 7 ALA A 145
PRO A 141
LEU A  14
LEU A  12
 None
 1.03A 4iomA-2dt9A:
undetectable		 4iomA-2dt9A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		5 / 8 ILE A 129
LEU A  12
VAL A 101
MET A 115
PHE A 116
 None
 1.18A 4r38B-2dt9A:
undetectable		 4r38B-2dt9A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		5 / 10 ILE A 129
LEU A  12
VAL A 101
MET A 115
PHE A 116
 None
 1.26A 4r3aB-2dt9A:
2.5		 4r3aB-2dt9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		4 / 8 ILE A  24
PHE A  64
GLY A  20
LEU A  75
 None
 0.90A 5esjA-2dt9A:
undetectable		 5esjA-2dt9A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		4 / 7 ILE A  24
PHE A  64
GLY A  20
LEU A  75
 None
 0.99A 5esmA-2dt9A:
undetectable		 5esmA-2dt9A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		4 / 8 VAL A  45
GLN A  18
GLY A  20
LEU A  21
 None
 0.81A 5w3jB-2dt9A:
undetectable		 5w3jB-2dt9A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2dt9 ASPARTOKINASE
(Thermus
thermophilus) 		4 / 8 VAL A  66
GLN A  18
GLY A  20
LEU A  21
 None
 0.87A 5w3jB-2dt9A:
undetectable		 5w3jB-2dt9A:
16.19