SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dtc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A
(Mus
musculus) 		5 / 10 LEU A  81
LEU A 107
SER A  32
LEU A  31
LEU A   7
 None
 1.05A 4yiaA-2dtcA:
undetectable		 4yiaA-2dtcA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A
(Mus
musculus) 		4 / 7 ILE A  62
VAL A  60
TYR A  38
ARG A   9
 None
 0.86A 5kkzC-2dtcA:
undetectable
5kkzE-2dtcA:
undetectable		 5kkzC-2dtcA:
19.68
5kkzE-2dtcA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A
(Mus
musculus) 		4 / 7 ILE A  62
VAL A  60
TYR A  38
ARG A   9
 None
 0.86A 5kkzK-2dtcA:
undetectable
5kkzQ-2dtcA:
undetectable		 5kkzK-2dtcA:
12.93
5kkzQ-2dtcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A
(Mus
musculus) 		4 / 7 ILE A  62
VAL A  60
TYR A  38
ARG A   9
 None
 0.83A 5kkzM-2dtcA:
undetectable
5kkzO-2dtcA:
undetectable		 5kkzM-2dtcA:
19.68
5kkzO-2dtcA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A
(Mus
musculus) 		4 / 7 ALA A  34
THR A  35
VAL A  63
TRP A  65
 None
 0.89A 6cduA-2dtcA:
undetectable
6cduE-2dtcA:
undetectable		 6cduA-2dtcA:
17.24
6cduE-2dtcA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A
(Mus
musculus) 		4 / 7 ALA A  34
THR A  35
VAL A  63
TRP A  65
 None
 0.87A 6cduF-2dtcA:
undetectable
6cduJ-2dtcA:
undetectable		 6cduF-2dtcA:
17.24
6cduJ-2dtcA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2dtc RAL GUANINE
NUCLEOTIDE EXCHANGE
FACTOR RALGPS1A
(Mus
musculus) 		4 / 7 VAL A  63
TRP A  65
ALA A  34
THR A  35
 None
 0.80A 6cduH-2dtcA:
undetectable
6cduI-2dtcA:
undetectable		 6cduH-2dtcA:
17.24
6cduI-2dtcA:
17.24