SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2du3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 389
VAL A 385
GLU A 433
ASP A 466
 None
 1.27A 1s3zA-2du3A:
undetectable
1s3zB-2du3A:
undetectable		 1s3zA-2du3A:
14.34
1s3zB-2du3A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 5 SER A 233
LEU A  72
GLY A 190
CYH A 214
 SEP  A1001 (-2.3A)
None
None
SEP  A1001 ( 4.8A)
 1.17A 3aiaA-2du3A:
undetectable
3aiaB-2du3A:
undetectable		 3aiaA-2du3A:
18.70
3aiaB-2du3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 339
ASP A 342
TYR A 340
ARG A 344
 None
 1.27A 3arrA-2du3A:
undetectable		 3arrA-2du3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 8 GLY A 246
GLY A 307
TYR A 273
VAL A 323
 None
 0.86A 4fgzA-2du3A:
undetectable		 4fgzA-2du3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		3 / 3 ILE A 380
MET A 408
ARG A 410
 None
 0.94A 4lnwA-2du3A:
undetectable		 4lnwA-2du3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		3 / 3 ILE A 380
MET A 408
ARG A 410
 None
 0.94A 4lnxA-2du3A:
undetectable		 4lnxA-2du3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		3 / 3 MET A 324
GLN A  82
TYR A 317
 None
 1.09A 4udcA-2du3A:
undetectable		 4udcA-2du3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 8 VAL A 414
ILE A 380
ALA A 381
VAL A 489
VAL A 529
 None
 1.23A 5l94A-2du3A:
undetectable		 5l94A-2du3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		5 / 10 VAL A 476
GLU A 477
LEU A 425
ALA A 472
PRO A 372
 None
 1.44A 5mm4B-2du3A:
undetectable		 5mm4B-2du3A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 128
VAL A 152
LEU A 148
VAL A 123
 None
 0.97A 5x7zA-2du3A:
0.8		 5x7zA-2du3A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 309
HIS A 186
MET A 187
 None
SEP  A1001 (-3.8A)
None
 1.21A 6af6A-2du3A:
undetectable		 6af6A-2du3A:
20.70