SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2du7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.13A 1fohA-2du7A:
undetectable		 1fohA-2du7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.12A 1fohB-2du7A:
undetectable		 1fohB-2du7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.10A 1fohC-2du7A:
undetectable		 1fohC-2du7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.09A 1fohD-2du7A:
undetectable		 1fohD-2du7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 200
ARG A 103
TYR A 285
TYR A 286
TYR A 313
 None
 1.14A 1httB-2du7A:
17.9		 1httB-2du7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ARG A  48
VAL A 536
VAL A 440
SER A 474
LEU A 517
 None
 1.13A 1igxA-2du7A:
0.6		 1igxA-2du7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  70
HIS A 198
ASN A  80
VAL A 327
TYR A 313
 None
 1.05A 1mrlB-2du7A:
undetectable
1mrlC-2du7A:
undetectable		 1mrlB-2du7A:
15.55
1mrlC-2du7A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_C_DOLC302_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 327
TYR A 313
TYR A  70
HIS A 198
ASN A  80
 None
 1.02A 1mrlA-2du7A:
0.0
1mrlC-2du7A:
0.0		 1mrlA-2du7A:
15.55
1mrlC-2du7A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.13A 1pn0A-2du7A:
undetectable		 1pn0A-2du7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.13A 1pn0B-2du7A:
undetectable		 1pn0B-2du7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.08A 1pn0C-2du7A:
undetectable		 1pn0C-2du7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.09A 1pn0D-2du7A:
undetectable		 1pn0D-2du7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 308
GLY A 333
SER A 245
ALA A 262
ILE A 305
 None
 1.20A 1ve3A-2du7A:
undetectable		 1ve3A-2du7A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 458
GLY A 538
PRO A 539
 None
 0.93A 2hreB-2du7A:
undetectable		 2hreB-2du7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 SER A 245
ALA A 244
SER A 243
SER A 222
 None
 1.06A 2i91B-2du7A:
undetectable		 2i91B-2du7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 517
THR A 475
ASP A  43
ARG A  48
ILE A 477
 None
 1.49A 3bexC-2du7A:
undetectable
3bexD-2du7A:
undetectable		 3bexC-2du7A:
19.60
3bexD-2du7A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A  43
ARG A  48
ILE A 477
LYS A 518
LEU A 517
 None
 1.16A 3bf1A-2du7A:
undetectable
3bf1B-2du7A:
undetectable		 3bf1A-2du7A:
19.60
3bf1B-2du7A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LYS A 518
LEU A 517
ASP A  43
ARG A  48
ILE A 477
 None
 1.12A 3bf1E-2du7A:
undetectable
3bf1F-2du7A:
undetectable		 3bf1E-2du7A:
19.60
3bf1F-2du7A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 369
ILE A 365
ILE A 534
SER A 511
LEU A 524
 None
 1.26A 3o1xA-2du7A:
undetectable		 3o1xA-2du7A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A 380
ILE A 491
PHE A 383
PHE A 409
 None
 0.92A 3owxB-2du7A:
undetectable		 3owxB-2du7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 409
ASN A 382
PHE A 383
ALA A 384
 None
 1.17A 3t3sB-2du7A:
undetectable		 3t3sB-2du7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 265
ARG A  67
GLN A 268
GLU A  77
PHE A 221
 None
 1.45A 3ua5B-2du7A:
0.0		 3ua5B-2du7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 258
GLY A 311
TYR A 285
VAL A 327
 None
 0.85A 4fgzA-2du7A:
undetectable		 4fgzA-2du7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A 446
ILE A 534
ASP A 444
ILE A 464
ASN A 438
 None
 1.17A 4o1eB-2du7A:
undetectable		 4o1eB-2du7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 482
ILE A  42
PHE A 380
TYR A 381
ILE A 418
 None
 0.90A 4pd4C-2du7A:
undetectable		 4pd4C-2du7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 482
ILE A 484
PHE A 380
TYR A 381
ILE A 418
 None
 1.07A 4pd4C-2du7A:
undetectable		 4pd4C-2du7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 345
GLU A 357
ALA A 349
TYR A 344
 None
 1.19A 4zz8A-2du7A:
undetectable		 4zz8A-2du7A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 200
ARG A 103
TYR A 285
TYR A 286
TYR A 313
 None
 1.20A 5e3iA-2du7A:
17.8		 5e3iA-2du7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 265
SER A 245
GLY A 331
GLY A 333
VAL A 334
 None
 1.25A 5o4yD-2du7A:
undetectable
5o4yE-2du7A:
undetectable		 5o4yD-2du7A:
7.92
5o4yE-2du7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 436
TYR A 479
GLU A 424
 None
 0.94A 5zmqD-2du7A:
undetectable
5zmqE-2du7A:
undetectable		 5zmqD-2du7A:
16.45
5zmqE-2du7A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 241
HIS A 198
MET A 199
 None
 0.93A 6af6A-2du7A:
undetectable		 6af6A-2du7A:
19.42