SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EIZ_A_SAMA301_1 (FTSJ)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	ASP A 78 ASP A 82 ASP A 120	None	0.68A	1eizA-2dulA: 9.6	1eizA-2dulA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EJ0_A_SAMA301_1 (FTSJ)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	ASP A 78 ASP A 82 ASP A 120	None	0.69A	1ej0A-2dulA: 9.7	1ej0A-2dulA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_J_TRPJ81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 8	ALA A 220 GLY A 202 ALA A 229 ILE A 204	None	0.62A	1gtnI-2dulA: undetectable 1gtnJ-2dulA: undetectable	1gtnI-2dulA: 11.70 1gtnJ-2dulA: 11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_A_BEZA349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifA-2dulA: 3.5	1kifA-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_B_BEZB349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifB-2dulA: 3.5	1kifB-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_C_BEZC349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifC-2dulA: 3.0	1kifC-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_D_BEZD349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifD-2dulA: 3.2	1kifD-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_E_BEZE349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifE-2dulA: 3.5	1kifE-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_F_BEZF349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifF-2dulA: 3.3	1kifF-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_G_BEZG349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifG-2dulA: 3.5	1kifG-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIF_H_BEZH349_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.32A	1kifH-2dulA: 3.5	1kifH-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	PHE A 134 LEU A 52 THR A 69 PRO A 48 PHE A 65	None	1.18A	1og5B-2dulA: undetectable	1og5B-2dulA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VE9_A_BEZA352_0 (D-AMINO ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.23A	1ve9A-2dulA: 3.5	1ve9A-2dulA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DU8_G_BEZG2352_0 (D-AMINO-ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.27A	2du8G-2dulA: 3.4	2du8G-2dulA: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DU8_J_BEZJ3352_0 (D-AMINO-ACID OXIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	TYR A 273 ILE A 250 ARG A 188 GLY A 189	None	1.25A	2du8J-2dulA: 3.5	2du8J-2dulA: 21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2EJT_A_SAMA501_0 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	6 / 12	ASP A 53 ILE A 63 ASN A 77 ILE A 79 SER A 80 ALA A 121	None	1.31A	2ejtA-2dulA: 62.9	2ejtA-2dulA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2EJT_A_SAMA501_0 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	11 / 12	ASP A 53 LEU A 55 ALA A 57 ILE A 60 ARG A 61 ASN A 77 ILE A 79 SER A 80 ALA A 121 ASP A 138 PHE A 146	None	0.20A	2ejtA-2dulA: 62.9	2ejtA-2dulA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2EJT_A_SAMA501_0 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	6 / 12	ILE A 63 ASN A 77 ILE A 79 SER A 80 ALA A 121 PHE A 27	None	1.17A	2ejtA-2dulA: 62.9	2ejtA-2dulA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2EJT_A_SAMA501_1 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	ARG A 36 ASP A 78 ASP A 120	None	0.23A	2ejtA-2dulA: 62.9	2ejtA-2dulA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PNJ_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 7	MET A 144 ILE A 204 PRO A 169 GLY A 196	None	1.06A	2pnjB-2dulA: 3.1	2pnjB-2dulA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q9R_A_BEZA203_0 (PROTEIN OF UNKNOWN FUNCTION)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 5	LEU A 67 GLY A 9 ILE A 60 ILE A 63	None	0.77A	2q9rA-2dulA: undetectable	2q9rA-2dulA: 18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXT_A_SAMA397_0 (PROBABLE N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE TRM1)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	10 / 12	ARG A 36 LEU A 55 ALA A 57 ILE A 60 ARG A 61 ASP A 78 ILE A 79 SER A 80 ALA A 121 ASP A 138	None	0.55A	3axtA-2dulA: 44.0	3axtA-2dulA: 38.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXT_A_SAMA397_0 (PROBABLE N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE TRM1)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	9 / 12	ARG A 36 LEU A 55 ALA A 57 ILE A 60 ARG A 61 SER A 80 ALA A 121 ASP A 138 PHE A 140	None	0.75A	3axtA-2dulA: 44.0	3axtA-2dulA: 38.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXT_A_SAMA397_0 (PROBABLE N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE TRM1)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	ILE A 63 ASP A 78 ILE A 79 SER A 80 ALA A 121	None	0.94A	3axtA-2dulA: 44.0	3axtA-2dulA: 38.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AY0_A_ADNA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 10	ASP A 78 ILE A 79 ALA A 83 ASP A 120 PHE A 146	None	0.46A	3ay0A-2dulA: 20.2	3ay0A-2dulA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_1 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	ASP A 78 ASP A 82 ASP A 120	None	0.68A	3douA-2dulA: 9.9	3douA-2dulA: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NMU_F_SAMF228_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE NOP5/NOP56 RELATED PROTEIN)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	ALA A 57 SER A 80 ASP A 120 ALA A 121 ASP A 138	None	0.86A	3nmuA-2dulA: undetectable 3nmuF-2dulA: 8.8	3nmuA-2dulA: 23.91 3nmuF-2dulA: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3POC_B_ACRB665_1 (ALPHA-GLUCOSIDASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 6	GLU A 260 ASP A 253 ASP A 254 LYS A 255	None	1.47A	3pocB-2dulA: undetectable	3pocB-2dulA: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3C_A_017A201_2 (HIV-1 PROTEASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 10	VAL A 231 ILE A 204 ILE A 199 ALA A 220 VAL A 217	None	0.98A	3t3cB-2dulA: undetectable	3t3cB-2dulA: 14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UA5_A_06XA502_1 (CYTOCHROME P450 2B6)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 11	ARG A 188 LEU A 187 PRO A 267 GLU A 262 VAL A 185	None	1.48A	3ua5A-2dulA: 0.0	3ua5A-2dulA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UVV_A_T3A501_1 (THYROID HORMONE RECEPTOR ALPHA)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	ILE A 13 ALA A 11 ALA A 66 LEU A 76 ILE A 114	None	0.86A	3uvvA-2dulA: undetectable	3uvvA-2dulA: 23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KIC_B_SAMB401_1 (METHYLTRANSFERASE MPPJ)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	ARG A 61 ASP A 78 ASP A 120	None	0.80A	4kicB-2dulA: 12.2	4kicB-2dulA: 24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_A_SAMA602_1 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	ASP A 138 ASN A 29 SER A 142	None	0.86A	4obwA-2dulA: 12.8	4obwA-2dulA: 24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P65_C_IPHC101_0 (INSULIN)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 11	LEU A 233 LEU A 151 ALA A 154 VAL A 162 LEU A 137	None	0.87A	4p65C-2dulA: undetectable 4p65D-2dulA: undetectable 4p65J-2dulA: undetectable 4p65L-2dulA: undetectable	4p65C-2dulA: 4.18 4p65D-2dulA: 6.12 4p65J-2dulA: 6.12 4p65L-2dulA: 6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P65_G_IPHG101_0 (INSULIN)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 11	VAL A 162 LEU A 137 LEU A 233 LEU A 151 ALA A 154	None	0.82A	4p65B-2dulA: undetectable 4p65D-2dulA: undetectable 4p65G-2dulA: undetectable 4p65H-2dulA: undetectable	4p65B-2dulA: 6.12 4p65D-2dulA: 6.12 4p65G-2dulA: 4.18 4p65H-2dulA: 6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P65_I_IPHI101_0 (INSULIN)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	VAL A 162 LEU A 137 LEU A 233 LEU A 151 ALA A 154	None	0.86A	4p65B-2dulA: undetectable 4p65D-2dulA: undetectable 4p65I-2dulA: undetectable 4p65J-2dulA: undetectable	4p65B-2dulA: 6.12 4p65D-2dulA: 6.12 4p65I-2dulA: 4.18 4p65J-2dulA: 6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P65_K_IPHK101_0 (INSULIN)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	VAL A 162 LEU A 137 LEU A 233 LEU A 151 ALA A 154	None	0.85A	4p65F-2dulA: undetectable 4p65H-2dulA: undetectable 4p65K-2dulA: undetectable 4p65L-2dulA: undetectable	4p65F-2dulA: 6.12 4p65H-2dulA: 6.12 4p65K-2dulA: 4.18 4p65L-2dulA: 6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V1F_B_BQ1B1087_0 (F0F1 ATP SYNTHASE SUBUNIT C)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 8	ALA A 208 ALA A 205 ILE A 204 ALA A 184 LEU A 200	None	1.33A	4v1fA-2dulA: undetectable 4v1fB-2dulA: undetectable	4v1fA-2dulA: 12.40 4v1fB-2dulA: 12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B6I_A_ADNA302_1 (FLUORINASE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	4 / 7	ASP A 323 THR A 360 PRO A 359 THR A 355	None	1.27A	5b6iA-2dulA: undetectable	5b6iA-2dulA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5INZ_D_DVAD15_0 (THETA DEFENSIN-2, D-PEPTIDE THETA DEFENSIN-2, L-PEPTIDE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	GLY A 189 CYH A 192 CYH A 171	None	0.92A	5inzB-2dulA: undetectable	5inzB-2dulA: 3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5INZ_D_DVAD15_0 (THETA DEFENSIN-2, D-PEPTIDE THETA DEFENSIN-2, L-PEPTIDE)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	3 / 3	GLY A 196 CYH A 171 CYH A 192	None	0.79A	5inzB-2dulA: undetectable	5inzB-2dulA: 3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUD_A_ERMA2001_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	LEU A 55 MET A 125 PHE A 132 LEU A 151 LEU A 160	None	1.17A	5tudA-2dulA: undetectable	5tudA-2dulA: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA902_0 (MRNA CAPPING ENZYME P5)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	LEU A 179 PRO A 275 ALA A 184 GLU A 260 PHE A 252	None	1.05A	5x6yA-2dulA: 6.3	5x6yA-2dulA: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_C_SAMC902_0 (MRNA CAPPING ENZYME P5)	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	5 / 12	LEU A 179 PRO A 275 ALA A 184 GLU A 260 PHE A 252	None	1.03A	5x6yC-2dulA: 3.8	5x6yC-2dulA: 18.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EIZ_A_SAMA301_1","FTSJ","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"ASP A  78;ASP A  82;ASP A 120","None","0.68A","1eizA-2dulA:9.6","1eizA-2dulA:19.67"],["1EJ0_A_SAMA301_1","FTSJ","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"ASP A  78;ASP A  82;ASP A 120","None","0.69A","1ej0A-2dulA:9.7","1ej0A-2dulA:19.67"],["1GTN_J_TRPJ81_0","TRP RNA-BINDING ATTENUATION PROTEIN","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"ALA A 220;GLY A 202;ALA A 229;ILE A 204","None","0.62A","1gtnI-2dulA:undetectable;1gtnJ-2dulA:undetectable","1gtnI-2dulA:11.70;1gtnJ-2dulA:11.70"],["1KIF_A_BEZA349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifA-2dulA:3.5","1kifA-2dulA:20.92"],["1KIF_B_BEZB349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifB-2dulA:3.5","1kifB-2dulA:20.92"],["1KIF_C_BEZC349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifC-2dulA:3.0","1kifC-2dulA:20.92"],["1KIF_D_BEZD349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifD-2dulA:3.2","1kifD-2dulA:20.92"],["1KIF_E_BEZE349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifE-2dulA:3.5","1kifE-2dulA:20.92"],["1KIF_F_BEZF349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifF-2dulA:3.3","1kifF-2dulA:20.92"],["1KIF_G_BEZG349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifG-2dulA:3.5","1kifG-2dulA:20.92"],["1KIF_H_BEZH349_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.32A","1kifH-2dulA:3.5","1kifH-2dulA:20.92"],["1OG5_B_SWFB502_1","CYTOCHROME P450 2C9","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"PHE A 134;LEU A  52;THR A  69;PRO A  48;PHE A  65","None","1.18A","1og5B-2dulA:undetectable","1og5B-2dulA:21.63"],["1VE9_A_BEZA352_0","D-AMINO ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.23A","1ve9A-2dulA:3.5","1ve9A-2dulA:20.92"],["2DU8_G_BEZG2352_0","D-AMINO-ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.27A","2du8G-2dulA:3.4","2du8G-2dulA:21.73"],["2DU8_J_BEZJ3352_0","D-AMINO-ACID OXIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"TYR A 273;ILE A 250;ARG A 188;GLY A 189","None","1.25A","2du8J-2dulA:3.5","2du8J-2dulA:21.73"],["2EJT_A_SAMA501_0","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",6,"ASP A  53;ILE A  63;ASN A  77;ILE A  79;SER A  80;ALA A 121","None","1.31A","2ejtA-2dulA:62.9","2ejtA-2dulA:100.00"],["2EJT_A_SAMA501_0","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",11,"ASP A  53;LEU A  55;ALA A  57;ILE A  60;ARG A  61;ASN A  77;ILE A  79;SER A  80;ALA A 121;ASP A 138;PHE A 146","None","0.20A","2ejtA-2dulA:62.9","2ejtA-2dulA:100.00"],["2EJT_A_SAMA501_0","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",6,"ILE A  63;ASN A  77;ILE A  79;SER A  80;ALA A 121;PHE A  27","None","1.17A","2ejtA-2dulA:62.9","2ejtA-2dulA:100.00"],["2EJT_A_SAMA501_1","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"ARG A  36;ASP A  78;ASP A 120","None","0.23A","2ejtA-2dulA:62.9","2ejtA-2dulA:100.00"],["2PNJ_B_CHDB502_0","FERROCHELATASE, MITOCHONDRIAL","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"MET A 144;ILE A 204;PRO A 169;GLY A 196","None","1.06A","2pnjB-2dulA:3.1","2pnjB-2dulA:23.36"],["2Q9R_A_BEZA203_0","PROTEIN OF UNKNOWN FUNCTION","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"LEU A  67;GLY A   9;ILE A  60;ILE A  63","None","0.77A","2q9rA-2dulA:undetectable","2q9rA-2dulA:18.25"],["3AXT_A_SAMA397_0","PROBABLE N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE TRM1","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",10,"ARG A  36;LEU A  55;ALA A  57;ILE A  60;ARG A  61;ASP A  78;ILE A  79;SER A  80;ALA A 121;ASP A 138","None","0.55A","3axtA-2dulA:44.0","3axtA-2dulA:38.52"],["3AXT_A_SAMA397_0","PROBABLE N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE TRM1","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",9,"ARG A  36;LEU A  55;ALA A  57;ILE A  60;ARG A  61;SER A  80;ALA A 121;ASP A 138;PHE A 140","None","0.75A","3axtA-2dulA:44.0","3axtA-2dulA:38.52"],["3AXT_A_SAMA397_0","PROBABLE N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE TRM1","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"ILE A  63;ASP A  78;ILE A  79;SER A  80;ALA A 121","None","0.94A","3axtA-2dulA:44.0","3axtA-2dulA:38.52"],["3AY0_A_ADNA401_1","UNCHARACTERIZED PROTEIN MJ0883","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"ASP A  78;ILE A  79;ALA A  83;ASP A 120;PHE A 146","None","0.46A","3ay0A-2dulA:20.2","3ay0A-2dulA:22.66"],["3DOU_A_SAMA1_1","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"ASP A  78;ASP A  82;ASP A 120","None","0.68A","3douA-2dulA:9.9","3douA-2dulA:18.68"],["3NMU_F_SAMF228_0","FIBRILLARIN-LIKE RRNA\/TRNA 2'-O-METHYLTRANSFERASE;NOP5\/NOP56 RELATED PROTEIN","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"ALA A  57;SER A  80;ASP A 120;ALA A 121;ASP A 138","None","0.86A","3nmuA-2dulA:undetectable;3nmuF-2dulA:8.8","3nmuA-2dulA:23.91;3nmuF-2dulA:20.26"],["3POC_B_ACRB665_1","ALPHA-GLUCOSIDASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"GLU A 260;ASP A 253;ASP A 254;LYS A 255","None","1.47A","3pocB-2dulA:undetectable","3pocB-2dulA:21.16"],["3T3C_A_017A201_2","HIV-1 PROTEASE;HIV-1 PROTEASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"VAL A 231;ILE A 204;ILE A 199;ALA A 220;VAL A 217","None","0.98A","3t3cB-2dulA:undetectable","3t3cB-2dulA:14.21"],["3UA5_A_06XA502_1","CYTOCHROME P450 2B6","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"ARG A 188;LEU A 187;PRO A 267;GLU A 262;VAL A 185","None","1.48A","3ua5A-2dulA:0.0","3ua5A-2dulA:21.02"],["3UVV_A_T3A501_1","THYROID HORMONE RECEPTOR ALPHA","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"ILE A  13;ALA A  11;ALA A  66;LEU A  76;ILE A 114","None","0.86A","3uvvA-2dulA:undetectable","3uvvA-2dulA:23.74"],["4KIC_B_SAMB401_1","METHYLTRANSFERASE MPPJ","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"ARG A  61;ASP A  78;ASP A 120","None","0.80A","4kicB-2dulA:12.2","4kicB-2dulA:24.94"],["4OBW_A_SAMA602_1","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"ASP A 138;ASN A  29;SER A 142","None","0.86A","4obwA-2dulA:12.8","4obwA-2dulA:24.29"],["4P65_C_IPHC101_0","INSULIN","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"LEU A 233;LEU A 151;ALA A 154;VAL A 162;LEU A 137","None","0.87A","4p65C-2dulA:undetectable;4p65D-2dulA:undetectable;4p65J-2dulA:undetectable;4p65L-2dulA:undetectable","4p65C-2dulA:4.18;4p65D-2dulA:6.12;4p65J-2dulA:6.12;4p65L-2dulA:6.12"],["4P65_G_IPHG101_0","INSULIN","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"VAL A 162;LEU A 137;LEU A 233;LEU A 151;ALA A 154","None","0.82A","4p65B-2dulA:undetectable;4p65D-2dulA:undetectable;4p65G-2dulA:undetectable;4p65H-2dulA:undetectable","4p65B-2dulA:6.12;4p65D-2dulA:6.12;4p65G-2dulA:4.18;4p65H-2dulA:6.12"],["4P65_I_IPHI101_0","INSULIN","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"VAL A 162;LEU A 137;LEU A 233;LEU A 151;ALA A 154","None","0.86A","4p65B-2dulA:undetectable;4p65D-2dulA:undetectable;4p65I-2dulA:undetectable;4p65J-2dulA:undetectable","4p65B-2dulA:6.12;4p65D-2dulA:6.12;4p65I-2dulA:4.18;4p65J-2dulA:6.12"],["4P65_K_IPHK101_0","INSULIN","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"VAL A 162;LEU A 137;LEU A 233;LEU A 151;ALA A 154","None","0.85A","4p65F-2dulA:undetectable;4p65H-2dulA:undetectable;4p65K-2dulA:undetectable;4p65L-2dulA:undetectable","4p65F-2dulA:6.12;4p65H-2dulA:6.12;4p65K-2dulA:4.18;4p65L-2dulA:6.12"],["4V1F_B_BQ1B1087_0","F0F1 ATP SYNTHASE SUBUNIT C","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"ALA A 208;ALA A 205;ILE A 204;ALA A 184;LEU A 200","None","1.33A","4v1fA-2dulA:undetectable;4v1fB-2dulA:undetectable","4v1fA-2dulA:12.40;4v1fB-2dulA:12.40"],["5B6I_A_ADNA302_1","FLUORINASE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",4,"ASP A 323;THR A 360;PRO A 359;THR A 355","None","1.27A","5b6iA-2dulA:undetectable","5b6iA-2dulA:21.52"],["5INZ_D_DVAD15_0","THETA DEFENSIN-2, D-PEPTIDE;THETA DEFENSIN-2, L-PEPTIDE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"GLY A 189;CYH A 192;CYH A 171","None","0.92A","5inzB-2dulA:undetectable","5inzB-2dulA:3.73"],["5INZ_D_DVAD15_0","THETA DEFENSIN-2, D-PEPTIDE;THETA DEFENSIN-2, L-PEPTIDE","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",3,"GLY A 196;CYH A 171;CYH A 192","None","0.79A","5inzB-2dulA:undetectable","5inzB-2dulA:3.73"],["5TUD_A_ERMA2001_1","5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"LEU A  55;MET A 125;PHE A 132;LEU A 151;LEU A 160","None","1.17A","5tudA-2dulA:undetectable","5tudA-2dulA:22.50"],["5X6Y_A_SAMA902_0","MRNA CAPPING ENZYME P5","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"LEU A 179;PRO A 275;ALA A 184;GLU A 260;PHE A 252","None","1.05A","5x6yA-2dulA:6.3","5x6yA-2dulA:18.77"],["5X6Y_C_SAMC902_0","MRNA CAPPING ENZYME P5","2dul","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","Pyrococcus horikoshii",5,"LEU A 179;PRO A 275;ALA A 184;GLU A 260;PHE A 252","None","1.03A","5x6yC-2dulA:3.8","5x6yC-2dulA:18.77"]]