SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		4 / 7 VAL A 143
SER A 150
PHE A 154
THR A 138
 None
 0.93A 2f78A-2dupA:
undetectable		 2f78A-2dupA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		4 / 7 VAL A 143
SER A 150
PHE A 154
THR A 138
 None
 0.97A 2f78B-2dupA:
undetectable		 2f78B-2dupA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.97A 2f80B-2dupA:
undetectable		 2f80B-2dupA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		4 / 6 SER A  71
PRO A  73
SER A  69
VAL A  67
 None
 1.29A 2hdnI-2dupA:
undetectable
2hdnJ-2dupA:
undetectable
2hdnL-2dupA:
undetectable		 2hdnI-2dupA:
11.90
2hdnJ-2dupA:
21.70
2hdnL-2dupA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		4 / 6 SER A  69
VAL A  67
SER A  71
PRO A  73
 None
 1.22A 2hdnJ-2dupA:
undetectable
2hdnK-2dupA:
undetectable
2hdnL-2dupA:
undetectable		 2hdnJ-2dupA:
21.70
2hdnK-2dupA:
11.90
2hdnL-2dupA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		4 / 6 PRO A 294
LEU A 157
ARG A 246
GLY A 244
 None
 1.10A 2hs2B-2dupA:
undetectable		 2hs2B-2dupA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.93A 2pymA-2dupA:
undetectable		 2pymA-2dupA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.92A 2pymB-2dupA:
undetectable		 2pymB-2dupA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 258
GLU A  98
VAL A 120
ILE A 133
 None
 1.21A 2wa2A-2dupA:
undetectable		 2wa2A-2dupA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		4 / 6 GLN A  78
ALA A 134
ALA A 257
THR A  91
 None
 1.07A 2xfhA-2dupA:
undetectable		 2xfhA-2dupA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 1.01A 3eluA-2dupA:
undetectable		 3eluA-2dupA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 10 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.91A 3em3A-2dupA:
undetectable		 3em3A-2dupA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 1.00A 3embA-2dupA:
undetectable		 3embA-2dupA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 1.02A 3gczA-2dupA:
undetectable		 3gczA-2dupA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.98A 3k4vD-2dupA:
undetectable		 3k4vD-2dupA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 6 VAL A 147
SER A 178
LEU A 247
ILE A 240
ALA A 158
 None
 1.41A 3kk6B-2dupA:
undetectable		 3kk6B-2dupA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.94A 3nduB-2dupA:
undetectable		 3nduB-2dupA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 9 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.95A 3oxvA-2dupA:
undetectable		 3oxvA-2dupA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		6 / 12 GLY A 132
GLY A 258
GLU A  98
ASP A 267
VAL A 120
ILE A 133
 None
 1.49A 3p97C-2dupA:
undetectable		 3p97C-2dupA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 11 SER A 178
ILE A 159
VAL A 226
VAL A 217
ILE A 242
 None
 1.37A 3rf4A-2dupA:
undetectable
3rf4C-2dupA:
undetectable		 3rf4A-2dupA:
17.08
3rf4C-2dupA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 11 ILE A 242
SER A 178
ILE A 159
VAL A 226
VAL A 217
 None
 1.33A 3rf4A-2dupA:
undetectable
3rf4B-2dupA:
undetectable		 3rf4A-2dupA:
17.08
3rf4B-2dupA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 11 ILE A 242
SER A 178
ILE A 159
VAL A 226
VAL A 217
 None
 1.30A 3rf4B-2dupA:
undetectable
3rf4C-2dupA:
undetectable		 3rf4B-2dupA:
17.08
3rf4C-2dupA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 9 PHE A 118
PHE A 206
ILE A 133
GLY A 132
THR A 163
 None
 1.23A 3t3rC-2dupA:
undetectable		 3t3rC-2dupA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		6 / 12 GLY A 132
GLY A 258
GLU A  98
ASP A 267
VAL A 120
ILE A 133
 None
 1.46A 4ctjA-2dupA:
undetectable		 4ctjA-2dupA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 5 PHE A 118
PHE A 206
ILE A 133
GLY A 132
THR A 163
 None
 1.30A 4ejjC-2dupA:
undetectable		 4ejjC-2dupA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.98A 4hlaA-2dupA:
undetectable		 4hlaA-2dupA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 11 LEU A 224
GLY A 201
ALA A 200
VAL A 245
ILE A 242
 None
 0.96A 4hlaB-2dupA:
undetectable		 4hlaB-2dupA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 LEU A 135
ILE A 268
VAL A  88
LEU A  83
LEU A  90
 None
 1.36A 4m11A-2dupA:
undetectable		 4m11A-2dupA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 ARG A 172
ILE A 177
GLY A 201
ILE A 159
ILE A 242
 None
 1.03A 4q5mA-2dupA:
undetectable		 4q5mA-2dupA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		3 / 3 SER A 270
ASP A 205
ASP A 212
 None
 0.61A 4uckA-2dupA:
undetectable		 4uckA-2dupA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 0.99A 5ehiA-2dupA:
undetectable		 5ehiA-2dupA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 1.01A 5ehiC-2dupA:
undetectable		 5ehiC-2dupA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 0.99A 5eiwA-2dupA:
undetectable		 5eiwA-2dupA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 0.97A 5ekxA-2dupA:
undetectable		 5ekxA-2dupA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 GLY A 132
GLY A 130
GLY A 260
THR A 163
ILE A 133
 None
GOL  A   7 ( 4.9A)
GOL  A   7 (-3.6A)
None
None
 0.96A 5njvC-2dupA:
undetectable		 5njvC-2dupA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		5 / 12 TRP A 136
ILE A 159
TYR A 188
VAL A 147
LEU A 224
 None
 1.43A 5nz0A-2dupA:
undetectable		 5nz0A-2dupA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36
(Canis
lupus) 		4 / 8 ASP A 131
HIS A 121
ASP A  93
GLU A  94
 GOL  A   7 (-3.3A)
None
None
None
 1.21A 6mn4A-2dupA:
undetectable		 6mn4A-2dupA:
21.86