SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 SER A 317
VAL A 321
ALA A 243
GLU A 353
 None
 1.06A 1dmiA-2dvlA:
undetectable
1dmiB-2dvlA:
undetectable		 1dmiA-2dvlA:
21.85
1dmiB-2dvlA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A  46
ALA A  42
LEU A  48
SER A  89
 None
 0.96A 1dvxA-2dvlA:
undetectable		 1dvxA-2dvlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A 132
LEU A 123
LEU A 225
ALA A 228
 None
FAD  A1001 (-4.4A)
None
None
 0.79A 1e7cA-2dvlA:
undetectable		 1e7cA-2dvlA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A 295
LEU A 293
GLU A 356
ALA A 241
 None
 0.92A 1ie4B-2dvlA:
undetectable
1ie4D-2dvlA:
undetectable		 1ie4B-2dvlA:
16.80
1ie4D-2dvlA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ALA A  75
ARG A 248
GLN A 242
GLU A  72
 None
 1.32A 1lquB-2dvlA:
undetectable		 1lquB-2dvlA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU A  91
LEU A 112
VAL A  87
GLY A 119
ALA A 120
 None
 1.30A 1pxxB-2dvlA:
undetectable		 1pxxB-2dvlA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASN A 149
GLU A 138
ARG A 140
 None
 1.00A 3wxoA-2dvlA:
undetectable		 3wxoA-2dvlA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 PHE A 188
VAL A 205
ILE A 155
ALA A 200
 None
None
FAD  A1001 (-4.5A)
None
 1.01A 4eyzA-2dvlA:
undetectable		 4eyzA-2dvlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 PHE A 188
VAL A 205
ILE A 155
ALA A 200
 None
None
FAD  A1001 (-4.5A)
None
 1.02A 4eyzB-2dvlA:
undetectable		 4eyzB-2dvlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A 306
ALA A 309
ALA A 295
TRP A  67
TYR A  94
 None
 1.49A 4u14A-2dvlA:
3.5		 4u14A-2dvlA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A 306
ALA A 309
ALA A 295
TRP A  67
TYR A  94
 None
 1.47A 4u15A-2dvlA:
2.1		 4u15A-2dvlA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLU A 356
VAL A 237
THR A 306
ARG A 236
GLU A 369
 None
 1.24A 4ydqB-2dvlA:
undetectable		 4ydqB-2dvlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 GLY A  58
ARG A 114
GLY A 115
GLU A 116
 None
 1.21A 4z2eB-2dvlA:
1.5
4z2eC-2dvlA:
undetectable		 4z2eB-2dvlA:
22.90
4z2eC-2dvlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TRP A  37
ILE A  84
SER A 157
 None
 1.00A 5gqbA-2dvlA:
undetectable		 5gqbA-2dvlA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 196
VAL A 351
THR A 352
ALA A 199
LEU A 197
 None
 0.90A 5kpcA-2dvlA:
undetectable		 5kpcA-2dvlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A 243
GLY A 245
GLU A  73
LEU A  71
ASP A  78
 None
 1.46A 5vlmF-2dvlA:
undetectable		 5vlmF-2dvlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TYR A 345
VAL A 342
ILE A 253
GLU A 252
 None
 1.02A 5z3jA-2dvlA:
undetectable		 5z3jA-2dvlA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2dvl ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 VAL A  85
LEU A  74
LEU A  22
LEU A  46
 None
 0.91A 6f6sA-2dvlA:
undetectable
6f6sB-2dvlA:
undetectable		 6f6sA-2dvlA:
11.02
6f6sB-2dvlA:
12.46