SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		3 / 3 ALA A 382
VAL A 407
TRP A 406
 None
 0.88A 1micA-2dvmA:
undetectable
1micB-2dvmA:
undetectable		 1micA-2dvmA:
3.63
1micB-2dvmA:
3.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 386
ARG A 383
ILE A 412
 None
 0.82A 1uobA-2dvmA:
undetectable		 1uobA-2dvmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 359
ALA A 360
ILE A 352
PRO A 333
ILE A 335
 None
 1.38A 2dm6A-2dvmA:
6.5
2dm6B-2dvmA:
6.6		 2dm6A-2dvmA:
24.56
2dm6B-2dvmA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 195
ALA A 194
LEU A 202
SER A 139
 NAD  A2503 ( 3.3A)
None
None
NAD  A2503 ( 4.2A)
 0.79A 2wekB-2dvmA:
6.6		 2wekB-2dvmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  63
ASN A  64
GLY A  54
LEU A 340
THR A 400
 None
None
MES  A2759 ( 3.7A)
None
None
 1.19A 3eeyE-2dvmA:
5.2		 3eeyE-2dvmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  63
ASN A  64
GLY A  54
LEU A 340
THR A 400
 None
None
MES  A2759 ( 3.7A)
None
None
 1.19A 3eeyH-2dvmA:
5.2		 3eeyH-2dvmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  63
ASN A  64
GLY A  54
LEU A 340
THR A 400
 None
None
MES  A2759 ( 3.7A)
None
None
 1.15A 3eeyI-2dvmA:
5.3		 3eeyI-2dvmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  63
ASN A  64
GLY A  54
LEU A 340
THR A 400
 None
None
MES  A2759 ( 3.7A)
None
None
 1.20A 3eeyJ-2dvmA:
5.2		 3eeyJ-2dvmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A  71
ARG A  74
ILE A  81
VAL A  89
 None
NAD  A2503 ( 4.4A)
None
None
 1.17A 3eigA-2dvmA:
undetectable		 3eigA-2dvmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 VAL A 315
MET A 286
ILE A 283
ILE A 302
 None
 1.03A 3hgxA-2dvmA:
undetectable		 3hgxA-2dvmA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 332
ILE A 359
VAL A 380
GLY A 334
 None
 0.75A 3hjoB-2dvmA:
undetectable		 3hjoB-2dvmA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 291
ALA A 316
LEU A 295
LEU A 205
VAL A 266
 None
None
NAD  A2503 ( 4.2A)
None
None
 1.14A 3ix9B-2dvmA:
undetectable		 3ix9B-2dvmA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 133
ASP A 160
VAL A 168
GLY A 334
ILE A 335
 None
 1.20A 3k13A-2dvmA:
undetectable		 3k13A-2dvmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 133
ASP A 160
VAL A 168
GLY A 334
ILE A 335
 None
 1.20A 3k13B-2dvmA:
undetectable		 3k13B-2dvmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 133
ASP A 160
VAL A 168
GLY A 334
ILE A 335
 None
 1.21A 3k13C-2dvmA:
undetectable		 3k13C-2dvmA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 209
ALA A 171
GLY A 172
LEU A 177
ILE A 184
 None
 0.95A 3ku1A-2dvmA:
2.5		 3ku1A-2dvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 209
ALA A 171
GLY A 172
LEU A 177
ILE A 184
 None
 0.97A 3ku1G-2dvmA:
undetectable		 3ku1G-2dvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 5 PHE A 270
ILE A 278
ASN A 327
PHE A 192
 NAD  A2503 ( 4.7A)
None
None
None
 1.17A 3octA-2dvmA:
undetectable		 3octA-2dvmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  91
LEU A  87
LEU A  78
 None
 0.75A 3ohtA-2dvmA:
undetectable		 3ohtA-2dvmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 278
LEU A 261
ALA A 312
ALA A 290
 None
 0.88A 3r9tB-2dvmA:
undetectable		 3r9tB-2dvmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A 101
GLY A 102
ASN A  64
ILE A 415
 None
 0.92A 4fglD-2dvmA:
3.6		 4fglD-2dvmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A 200
ILE A 326
ALA A 356
ILE A 204
VAL A 169
VAL A 168
 None
NAD  A2503 ( 4.8A)
None
None
None
None
 1.46A 4nkxB-2dvmA:
undetectable		 4nkxB-2dvmA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 177
ILE A 187
GLY A 209
ALA A 208
ALA A 166
 None
 1.04A 4nkxC-2dvmA:
undetectable		 4nkxC-2dvmA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 177
ILE A 187
GLY A 209
ALA A 208
ALA A 166
 None
 0.99A 4nkxD-2dvmA:
undetectable		 4nkxD-2dvmA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 353
ALA A 356
ALA A 355
LEU A 170
ALA A 171
 None
 1.14A 4nqaH-2dvmA:
undetectable		 4nqaH-2dvmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 11 CYH A 142
ALA A 194
GLY A 198
THR A 201
ALA A 200
 None
 1.13A 4qvvH-2dvmA:
undetectable		 4qvvH-2dvmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 11 CYH A 142
ALA A 194
GLY A 198
THR A 201
ALA A 200
 None
 1.13A 4qvvV-2dvmA:
undetectable		 4qvvV-2dvmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 11 ASN A 222
GLU A 254
VAL A 221
LEU A 228
THR A 229
 None
 1.46A 4yhaD-2dvmA:
undetectable		 4yhaD-2dvmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 8 ASN A 175
ALA A 176
VAL A 179
GLU A 369
 None
 0.82A 4zbqA-2dvmA:
2.7		 4zbqA-2dvmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 192
SER A 185
VAL A 210
ASP A 265
 None
 1.30A 5hesA-2dvmA:
undetectable		 5hesA-2dvmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 CYH A 142
ALA A 194
GLY A 198
THR A 201
ALA A 200
 None
 1.10A 5l5fH-2dvmA:
undetectable
5l5fI-2dvmA:
undetectable		 5l5fH-2dvmA:
21.92
5l5fI-2dvmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2dvm 439AA LONG
HYPOTHETICAL MALATE
OXIDOREDUCTASE
(Pyrococcus
horikoshii) 		5 / 12 CYH A 142
ALA A 194
GLY A 198
THR A 201
ALA A 200
 None
 1.10A 5l5fV-2dvmA:
undetectable
5l5fW-2dvmA:
undetectable		 5l5fV-2dvmA:
21.92
5l5fW-2dvmA:
19.68