SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 8 HIS A 209
LEU A 205
GLU A 153
TRP A 151
 None
 1.07A 1i7zA-2dvuA:
undetectable		 1i7zA-2dvuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 8 LEU A 283
THR A 260
ALA A 296
ILE A  52
 None
 0.84A 3jusA-2dvuA:
undetectable		 3jusA-2dvuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 8 LEU A 283
THR A 260
ALA A 296
ILE A  52
 None
 0.84A 3jusA-2dvuA:
undetectable		 3jusA-2dvuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 8 LEU A 283
THR A 260
GLY A 263
ALA A 296
ILE A  52
 None
 1.09A 3jusB-2dvuA:
undetectable		 3jusB-2dvuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 9 LEU A 283
THR A 260
GLY A 263
ALA A 296
ILE A  52
 None
 1.09A 3jusB-2dvuA:
undetectable		 3jusB-2dvuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 10 ALA A  99
VAL A 123
ILE A 215
LEU A 321
ILE A  56
 None
 1.10A 3jw3A-2dvuA:
undetectable		 3jw3A-2dvuA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 9 ALA A  99
VAL A 123
ILE A 215
LEU A 321
ILE A  56
 None
 1.19A 3jw3B-2dvuA:
undetectable		 3jw3B-2dvuA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 5 LEU A 140
GLN A 137
THR A 138
GLU A 133
 None
 1.20A 3n58C-2dvuA:
undetectable		 3n58C-2dvuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 6 VAL A  83
ASN A  81
GLU A  15
ILE A  76
 None
 1.10A 3q5sA-2dvuA:
undetectable		 3q5sA-2dvuA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 4 GLY A 134
GLY A 136
THR A 138
LEU A 140
 None
 0.79A 3si7C-2dvuA:
undetectable
3si7D-2dvuA:
undetectable		 3si7C-2dvuA:
21.35
3si7D-2dvuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 6 ILE A 293
THR A 286
SER A 297
ASP A  93
 None
 1.01A 4iaqA-2dvuA:
undetectable		 4iaqA-2dvuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 12 SER A  20
ALA A 100
PHE A  98
LEU A  57
ARG A  43
 None
 1.27A 4z7fC-2dvuA:
undetectable		 4z7fC-2dvuA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 12 ALA A 100
ALA A  97
LEU A  84
ASN A  81
HIS A  10
 None
None
None
None
ZN  A1501 ( 3.3A)
 1.28A 4zo1X-2dvuA:
undetectable		 4zo1X-2dvuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 7 LEU A 101
GLN A  65
PHE A 150
LEU A 113
 None
 0.93A 5b1bP-2dvuA:
undetectable
5b1bW-2dvuA:
undetectable		 5b1bP-2dvuA:
19.46
5b1bW-2dvuA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 7 LEU A 321
PRO A 160
ILE A 214
LEU A 216
 None
 0.91A 5fxtA-2dvuA:
undetectable		 5fxtA-2dvuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 11 LEU A 321
VAL A 159
TYR A 162
GLY A 124
LEU A   7
 None
 1.49A 5hbmA-2dvuA:
undetectable		 5hbmA-2dvuA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		3 / 3 TYR A 162
HIS A 218
MET A 219
 None
 1.25A 6af6A-2dvuA:
undetectable		 6af6A-2dvuA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 8 GLY A  51
ILE A  52
ASP A 298
ASP A 294
 None
 1.02A 6ag0C-2dvuA:
4.2		 6ag0C-2dvuA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		5 / 10 LEU A 321
VAL A 159
TYR A 162
GLY A 124
LEU A   7
 None
 1.47A 6bsiA-2dvuA:
undetectable		 6bsiA-2dvuA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2dvu THERMOPHILIC
REVERSIBLE
GAMMA-RESORCYLATE
DECARBOXYLASE
(Rhizobium
sp.
MTP-10005) 		4 / 8 ASP A  38
HIS A  10
ARG A  35
HIS A  34
 None
ZN  A1501 ( 3.3A)
None
None
 1.24A 6mn4B-2dvuA:
undetectable		 6mn4B-2dvuA:
23.69