SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.22A 1os2A-2dw1A:
10.3		 1os2A-2dw1A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.21A 1os2D-2dw1A:
10.3		 1os2D-2dw1A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 LEU A 290
TRP A 273
LEU A 248
GLN A 288
 None
 1.37A 1p93D-2dw1A:
undetectable		 1p93D-2dw1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		5 / 12 ASN A 286
ILE A 235
VAL A 243
ALA A 244
LEU A 204
 None
 1.32A 1udtA-2dw1A:
undetectable		 1udtA-2dw1A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.24A 1uttA-2dw1A:
10.5		 1uttA-2dw1A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.21A 1utzA-2dw1A:
10.5		 1utzA-2dw1A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.23A 1utzB-2dw1A:
10.5		 1utzB-2dw1A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 6 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.22A 1y93A-2dw1A:
10.6		 1y93A-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.20A 2hu6A-2dw1A:
10.5		 2hu6A-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 8 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.18A 2jihB-2dw1A:
26.5		 2jihB-2dw1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 6 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.27A 2ow9A-2dw1A:
10.1		 2ow9A-2dw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.23A 2ow9B-2dw1A:
10.0		 2ow9B-2dw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.27A 2ozrC-2dw1A:
9.8		 2ozrC-2dw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.25A 2ozrD-2dw1A:
9.8		 2ozrD-2dw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.31A 2ozrE-2dw1A:
9.4		 2ozrE-2dw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		3 / 3 HIS A 333
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.33A 2ozrF-2dw1A:
9.8		 2ozrF-2dw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 TYR A 559
GLY A 536
ARG A 557
TYR A 534
 None
 1.29A 2wb9A-2dw1A:
0.0		 2wb9A-2dw1A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		3 / 3 PHE A 197
ASN A 195
PHE A 199
 None
 0.93A 2zbuD-2dw1A:
3.4		 2zbuD-2dw1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		3 / 3 HIS A 343
HIS A 337
HIS A 333
 ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.4A)
 0.74A 3bvdA-2dw1A:
undetectable		 3bvdA-2dw1A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.24A 3kecA-2dw1A:
10.1		 3kecA-2dw1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.23A 3likA-2dw1A:
10.6		 3likA-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.25A 3lilA-2dw1A:
10.6		 3lilA-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		5 / 5 ILE A 299
HIS A 333
GLU A 334
HIS A 337
HIS A 343
 GM6  A   2 (-3.6A)
ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 1.40A 3ljgA-2dw1A:
10.6		 3ljgA-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.20A 3lkaA-2dw1A:
10.5		 3lkaA-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 VAL A 329
ILE A 317
MET A 307
ARG A 358
 None
 1.25A 3oezA-2dw1A:
undetectable		 3oezA-2dw1A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 VAL A 329
ILE A 317
MET A 307
ARG A 358
 None
 1.19A 3pyyB-2dw1A:
undetectable		 3pyyB-2dw1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		3 / 3 HIS A 343
HIS A 337
HIS A 333
 ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.4A)
 0.77A 3s38A-2dw1A:
undetectable		 3s38A-2dw1A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 6 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.33A 4a7bA-2dw1A:
9.8		 4a7bA-2dw1A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.23A 5n5jA-2dw1A:
10.5		 5n5jA-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.23A 5n5kA-2dw1A:
10.6		 5n5kA-2dw1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 5 PRO A 587
GLY A 588
THR A 589
LYS A 590
 None
 1.03A 5x23A-2dw1A:
undetectable		 5x23A-2dw1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 6 PRO A 587
GLY A 588
THR A 589
LYS A 590
 None
 0.98A 5x24A-2dw1A:
undetectable		 5x24A-2dw1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 6 PRO A 587
GLY A 588
THR A 589
LYS A 590
 None
 0.93A 5xxiA-2dw1A:
undetectable		 5xxiA-2dw1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		5 / 12 ILE A 317
VAL A 232
ILE A 228
MET A 335
LEU A 278
 None
 0.92A 5ycnA-2dw1A:
undetectable		 5ycnA-2dw1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2dw1 CATROCOLLASTATIN
(Crotalus
atrox) 		4 / 4 HIS A 284
VAL A 205
LEU A 278
ALA A 287
 None
 1.40A 6d8pB-2dw1A:
4.3		 6d8pB-2dw1A:
19.75