SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 316
LEU A 336
THR A 303
TYR A 260
GLU A 213
 None
 1.36A 1kw0A-2dwcA:
undetectable		 1kw0A-2dwcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 316
LEU A 336
THR A 303
TYR A 260
GLU A 213
 None
 1.38A 1mmtA-2dwcA:
undetectable		 1mmtA-2dwcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A  86
LEU A  23
VAL A  48
ALA A  52
 None
 0.98A 1mz9C-2dwcA:
undetectable		 1mz9C-2dwcA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 127
LEU A 128
VAL A 134
 None
 0.59A 1mz9E-2dwcA:
undetectable		 1mz9E-2dwcA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 405
HIS A 346
HIS A 409
 None
 0.70A 1oe2A-2dwcA:
undetectable		 1oe2A-2dwcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 GLU A 102
ALA A  85
LEU A  23
VAL A 321
 None
 0.93A 1sn5C-2dwcA:
undetectable		 1sn5C-2dwcA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 122
GLU A 202
LEU A 148
 None
ADP  A 501 (-4.1A)
None
 0.70A 1v8bB-2dwcA:
3.9		 1v8bB-2dwcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A  51
ARG A 386
GLU A  29
TYR A 382
 None
None
SO4  A 604 ( 4.7A)
SO4  A 604 (-4.8A)
 1.14A 2fl5E-2dwcA:
3.2
2fl5F-2dwcA:
undetectable		 2fl5E-2dwcA:
19.16
2fl5F-2dwcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 397
ASP A 396
GLU A 250
 None
 0.64A 2qeuA-2dwcA:
undetectable		 2qeuA-2dwcA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 397
ASP A 396
GLU A 250
 None
 0.64A 2qeuC-2dwcA:
undetectable		 2qeuC-2dwcA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 316
LEU A 324
GLY A 323
PHE A 337
VAL A   3
 None
 1.26A 2w8yA-2dwcA:
undetectable		 2w8yA-2dwcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 295
MET A 165
GLU A 202
GLU A 291
 None
None
ADP  A 501 (-4.1A)
ADP  A 501 (-3.2A)
 1.26A 3dh0A-2dwcA:
3.4		 3dh0A-2dwcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 323
ASP A  84
ILE A 225
GLY A 272
LEU A   7
 None
 0.98A 3eeyH-2dwcA:
3.5		 3eeyH-2dwcA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A  59
GLY A  28
SER A  27
ARG A 385
ILE A 389
 None
None
None
SO4  A 604 (-3.9A)
None
 1.04A 3mb5A-2dwcA:
3.9		 3mb5A-2dwcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A 307
VAL A 302
HIS A 218
GLU A 213
LEU A 214
 None
 1.39A 3wfhA-2dwcA:
2.6
3wfhB-2dwcA:
2.5		 3wfhA-2dwcA:
19.77
3wfhB-2dwcA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A 307
VAL A 302
HIS A 218
GLU A 213
LEU A 214
 None
 1.40A 3whxA-2dwcA:
undetectable
3whxB-2dwcA:
2.2		 3whxA-2dwcA:
19.49
3whxB-2dwcA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A 324
VAL A 216
LEU A 316
ILE A 326
PHE A 314
 None
 1.36A 4r38D-2dwcA:
undetectable		 4r38D-2dwcA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 124
ARG A 121
ARG A 125
 None
ADP  A 501 (-2.6A)
None
 0.90A 4yiaB-2dwcA:
undetectable		 4yiaB-2dwcA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 310
ILE A 251
GLY A 234
THR A 299
LEU A 214
 None
 1.20A 4zdyA-2dwcA:
undetectable		 4zdyA-2dwcA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  34
LEU A 322
ALA A  85
HIS A 317
 None
 1.02A 5hrqE-2dwcA:
undetectable
5hrqF-2dwcA:
undetectable
5hrqJ-2dwcA:
undetectable		 5hrqE-2dwcA:
3.85
5hrqF-2dwcA:
6.18
5hrqJ-2dwcA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A 346
HIS A 243
VAL A 347
ALA A 408
 None
 1.23A 5i3bB-2dwcA:
undetectable		 5i3bB-2dwcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 VAL A 373
LEU A 375
ALA A 390
LEU A 366
 None
 0.57A 5jq7A-2dwcA:
undetectable		 5jq7A-2dwcA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A 335
HIS A 218
LEU A 316
PRO A 230
 None
 1.27A 5syjA-2dwcA:
undetectable		 5syjA-2dwcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A 335
HIS A 218
LEU A 316
PRO A 230
 None
 1.27A 5syjB-2dwcA:
undetectable		 5syjB-2dwcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  60
GLY A  31
GLY A  28
ILE A  90
LEU A  74
 None
 1.11A 5ul4A-2dwcA:
6.0		 5ul4A-2dwcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 361
LEU A 362
LEU A 391
VAL A 373
LEU A 413
 None
 1.12A 5vkqB-2dwcA:
undetectable
5vkqC-2dwcA:
undetectable		 5vkqB-2dwcA:
13.37
5vkqC-2dwcA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 310
ILE A 251
GLY A 234
THR A 299
LEU A 214
 None
 1.16A 6e8qA-2dwcA:
undetectable		 6e8qA-2dwcA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 MET A 119
ALA A  97
LEU A  98
ALA A 112
 None
 1.20A 6fosB-2dwcA:
undetectable		 6fosB-2dwcA:
11.14