SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2dwg PROTEIN RUFY3
(Mus
musculus) 		3 / 3 LEU A 230
LEU A 217
PHE A 122
 None
 0.65A 2pgrA-2dwgA:
undetectable		 2pgrA-2dwgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2dwg PROTEIN RUFY3
(Mus
musculus) 		5 / 12 LEU A 101
ALA A  94
ILE A 226
LEU A 230
LEU A 233
 None
 0.95A 3adxB-2dwgA:
undetectable		 3adxB-2dwgA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2dwg PROTEIN RUFY3
(Mus
musculus) 		4 / 8 MET A 126
PHE A 122
ALA A 188
LEU A 189
 None
 0.99A 4rkuA-2dwgA:
1.8
4rkuJ-2dwgA:
undetectable		 4rkuA-2dwgA:
12.53
4rkuJ-2dwgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2dwg PROTEIN RUFY3
(Mus
musculus) 		4 / 7 MET A 126
PHE A 122
ALA A 188
LEU A 189
 None
 0.94A 4xk8A-2dwgA:
undetectable		 4xk8A-2dwgA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2dwg PROTEIN RUFY3
(Mus
musculus) 		5 / 10 PHE A 122
LEU A 119
GLY A 100
ILE A  98
ILE A 236
 None
 1.07A 6ebpC-2dwgA:
undetectable		 6ebpC-2dwgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2dwg PROTEIN RUFY3
(Mus
musculus) 		5 / 11 PHE A 122
LEU A 119
GLY A 100
ILE A  98
ILE A 236
 None
 1.06A 6ebzB-2dwgA:
undetectable		 6ebzB-2dwgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2dwg PROTEIN RUFY3
(Mus
musculus) 		5 / 11 PHE A 122
LEU A 119
GLY A 100
ILE A  98
ILE A 236
 None
 0.99A 6gp2B-2dwgA:
undetectable		 6gp2B-2dwgA:
21.74