SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.00A 1t85A-2dwzB:
undetectable		 1t85A-2dwzB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.03A 1t87A-2dwzB:
undetectable		 1t87A-2dwzB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.02A 1yrcA-2dwzB:
undetectable		 1yrcA-2dwzB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 6 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.02A 2feuA-2dwzB:
undetectable		 2feuA-2dwzB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.96A 2feuB-2dwzB:
undetectable		 2feuB-2dwzB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		5 / 12 SER B 371
THR B 349
PHE B 399
ILE B 378
PHE B 345
 None
 1.46A 2vdyA-2dwzB:
undetectable		 2vdyA-2dwzB:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 6 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.07A 2zuiA-2dwzB:
undetectable		 2zuiA-2dwzB:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.05A 2zwtA-2dwzB:
undetectable		 2zwtA-2dwzB:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.04A 2zwuA-2dwzB:
undetectable		 2zwuA-2dwzB:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.00A 3fwfA-2dwzB:
undetectable		 3fwfA-2dwzB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.98A 3fwfB-2dwzB:
undetectable		 3fwfB-2dwzB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.00A 3fwjA-2dwzB:
undetectable		 3fwjA-2dwzB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.97A 3l63A-2dwzB:
undetectable		 3l63A-2dwzB:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.96A 3wrhA-2dwzB:
undetectable		 3wrhA-2dwzB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.00A 3wrjA-2dwzB:
undetectable		 3wrjA-2dwzB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.99A 3wrlA-2dwzB:
undetectable		 3wrlA-2dwzB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.01A 3wrlE-2dwzB:
undetectable		 3wrlE-2dwzB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.99A 3wrmA-2dwzB:
undetectable		 3wrmA-2dwzB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 1.05A 3wrmF-2dwzB:
undetectable		 3wrmF-2dwzB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		5 / 12 SER B 371
THR B 349
PHE B 399
ILE B 378
PHE B 345
 None
 1.39A 4c49B-2dwzB:
undetectable		 4c49B-2dwzB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		5 / 12 SER B 371
THR B 349
PHE B 399
ILE B 378
PHE B 345
 None
 1.45A 4c49C-2dwzB:
undetectable		 4c49C-2dwzB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		5 / 12 SER B 371
THR B 349
PHE B 399
ILE B 378
PHE B 345
 None
 1.39A 4c49D-2dwzB:
undetectable		 4c49D-2dwzB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.91A 4l4gA-2dwzB:
undetectable		 4l4gA-2dwzB:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		5 / 12 PHE B 399
ILE B 378
ILE B 348
LEU B 360
VAL B 394
 None
 0.93A 5uvmB-2dwzB:
undetectable		 5uvmB-2dwzB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 6 ARG B 388
PHE B 399
ILE B 348
THR B 349
 None
 1.13A 5vceA-2dwzB:
undetectable		 5vceA-2dwzB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B
(Rattus
norvegicus) 		4 / 7 THR B 349
LEU B 354
VAL B 358
VAL B 364
 None
 0.91A 5wk9A-2dwzB:
undetectable		 5wk9A-2dwzB:
11.59