SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2dx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 8 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.17A 1v55N-2dx5A:
undetectable
1v55W-2dx5A:
undetectable		 1v55N-2dx5A:
12.45
1v55W-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 12 ILE A  48
ALA A  60
LEU A  40
LEU A 122
ILE A  82
 None
 1.19A 1xzxX-2dx5A:
undetectable		 1xzxX-2dx5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 8 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.23A 2einA-2dx5A:
undetectable
2einJ-2dx5A:
undetectable		 2einA-2dx5A:
12.45
2einJ-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		4 / 7 ILE A  82
LEU A 108
PHE A 110
ARG A 121
 None
 1.20A 2zxwN-2dx5A:
undetectable
2zxwW-2dx5A:
undetectable		 2zxwN-2dx5A:
12.45
2zxwW-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 8 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.25A 3abkA-2dx5A:
undetectable
3abkJ-2dx5A:
undetectable		 3abkA-2dx5A:
12.45
3abkJ-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 8 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.22A 3abmN-2dx5A:
undetectable
3abmW-2dx5A:
undetectable		 3abmN-2dx5A:
12.45
3abmW-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		4 / 7 ILE A  82
LEU A 108
PHE A 110
ARG A 121
 None
 1.04A 3ag2N-2dx5A:
undetectable
3ag2W-2dx5A:
undetectable		 3ag2N-2dx5A:
12.45
3ag2W-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		4 / 7 ILE A  82
LEU A 108
PHE A 110
ARG A 120
 None
 0.98A 3ag4N-2dx5A:
undetectable
3ag4W-2dx5A:
undetectable		 3ag4N-2dx5A:
12.45
3ag4W-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 8 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.22A 3asoN-2dx5A:
undetectable
3asoW-2dx5A:
undetectable		 3asoN-2dx5A:
12.45
3asoW-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		4 / 5 LEU A  47
SER A  43
LEU A  63
PRO A  62
 None
 1.23A 3onnA-2dx5A:
undetectable		 3onnA-2dx5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 12 TRP A  49
ILE A  48
THR A  39
VAL A  24
LEU A  11
 None
 1.29A 5nz0A-2dx5A:
undetectable		 5nz0A-2dx5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		4 / 8 ILE A  82
LEU A 108
PHE A 110
ARG A 121
 None
 0.75A 5zcoA-2dx5A:
undetectable
5zcoJ-2dx5A:
undetectable		 5zcoA-2dx5A:
12.45
5zcoJ-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36
(Mus
musculus) 		5 / 8 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.25A 5zcpN-2dx5A:
undetectable
5zcpW-2dx5A:
undetectable		 5zcpN-2dx5A:
12.45
5zcpW-2dx5A:
16.18